| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Megalin is highly expressed on the apical membrane of proximal tubular epithelial cells and plays an important role in the endocytic reabsorption of glomerular-filtered substances such as proteins and drugs. In this project, 1) we analyzed the role of megalin in the regulation of the intrarenal renin-angiotensin system. 2) We elucidated the mechanism underlying the development of chronic kidney disease and acute kidney injury via the uptake of nephrotoxic substances by megalin, an “entrance” molecule, into the kidney. 3) We analyzed the role of megalin in the regulation of phosphate. 4) We found that urinary megalin excretion is tightly linked with the pathogenesis of diabetic nephropathy and its measurement in urine is useful for the prediction of the development and progression of the disease.
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