The role of megalin in the pathogenesis of chronic kidney disease and the clinical significance of urinary megalin measurement
Project/Area Number |
26461216
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Niigata University |
Principal Investigator |
Saito Akihiko 新潟大学, 医歯学総合研究科, 特任教授 (80293207)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | メガリン / 慢性腎臓病 / レニン-アンジオテンシン系 / リン代謝 / バイオマーカー / レニンーアンジオテンシン系 / レニン-アンジオテンシン系 |
Outline of Final Research Achievements |
Megalin is highly expressed on the apical membrane of proximal tubular epithelial cells and plays an important role in the endocytic reabsorption of glomerular-filtered substances such as proteins and drugs. In this project, 1) we analyzed the role of megalin in the regulation of the intrarenal renin-angiotensin system. 2) We elucidated the mechanism underlying the development of chronic kidney disease and acute kidney injury via the uptake of nephrotoxic substances by megalin, an “entrance” molecule, into the kidney. 3) We analyzed the role of megalin in the regulation of phosphate. 4) We found that urinary megalin excretion is tightly linked with the pathogenesis of diabetic nephropathy and its measurement in urine is useful for the prediction of the development and progression of the disease.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity2017
Author(s)
Hori Y, Aoki N, Kuwahara S, Hosojima M, Kaseda R, Goto S, Iida T, De S, Kabasawa H, Kaneko R, Aoki H, Tanabe Y, Kagamu H, Narita I, Kikuchi T, Saito A.
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Journal Title
J Am Soc Nephrol
Volume: in press
Issue: 6
Pages: 1783-1791
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Exocytosis-Mediated Urinary Full-Length Megalin Excretion is Linked with the Pathogenesis of Diabetic Nephropathy2017
Author(s)
De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Sarkar P, Yoshioka Y, Kabasawa H, Iida T, Goto S, Toba K, Higuchi Y, Suzuki Y, Hara M, Kurosawa H, Narita I, Hirayama Y, Ochiya T, Saito A
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Journal Title
Diabetes
Volume: in press
Issue: 5
Pages: 1391-1404
DOI
Related Report
Peer Reviewed
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[Journal Article] Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease2016
Author(s)
Kuwahara S, Hosojima M, Kaneko R, Aoki H, Nakano D, Sasagawa T, Kabasawa H, Kaseda R, Yasukawa R, Ishikawa T, Suzuki A, Sato H, Kageyama S, Tanaka T, Kitamura N, Narita I, Komatsu M, Nishiyama A, Saito A
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Journal Title
J Am Soc Nephro
Volume: in press
Issue: 7
Pages: 1996-2008
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Beneficial effects of rice endosperm protein intake in Japanese men with risk factors for metabolic syndrome: a randomized, crossover clinical trial.2016
Author(s)
Hosojima M, Kaseda R, Kondo H, Fujii M, Kubota M, Watanabe R, Tanabe N, Kadowaki M, Suzuki Y, Saito A
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Journal Title
BMC Nutrition
Volume: 2
Issue: 1
Pages: 25-33
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Significance of urinary full-length megalin in patients with IgA nephropathy.2014
Author(s)
Seki T, Asanuma K, Asao R, Nonaka K, Sasaki Y, Oliva Trejo JA, Kurosawa H, Hirayama Y, Horikoshi S, Tomino Y, Saito A.
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Journal Title
PLoS One
Volume: 9(12)
Issue: 12
Pages: e114400-e114400
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Two forms of urinary megalin excretion are novel predictors of the progression of early-stage diabetic nephropathy in Type 2 diabetes mellitus2016
Author(s)
Iida T, Hosojima M, Kabasawa K, Nakamura K, Kuwahara S, Ishikawa T, Kaseda R, Suzuki Y, Kurosawa H, Hirayama Y, Narita I, Saito A
Organizer
49th Annual Meeting of American Society of Nephrology
Place of Presentation
McCormick Place(Chicago, USA)
Year and Date
2016-11-15
Related Report
Int'l Joint Research
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[Presentation] Mechanisms underlying urinary excretion of full-length and extracellular domain forms of megalin2016
Author(s)
De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Yoshioka Y, Suzuki Y, Narita I, Ochiya T, Kurosawa H, Hirayama Y, Saito A
Organizer
The 59th Annual Meeting of the Japanese Society of Nephrology
Place of Presentation
Pacifico Yokohama(神奈川県横浜市)
Year and Date
2016-06-17
Related Report
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[Presentation] Mechanism of increased urinary full-length megalin excretion in type 2 diabetes mellitus patients with nephropathy2015
Author(s)
De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Yoshioka Y, Suzuki Y, Narita I, Ochiya T, Saito A
Organizer
48th Annual Meeting of American Society of Nephrology
Place of Presentation
San Diego Convention Center(San Diego, USA)
Year and Date
2015-11-03
Related Report
Int'l Joint Research
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[Presentation] Prospective cross-sectional and longitudinal observational study of urinary podocyte markers and urinary megalin in kidney disease of ANCA-associated vasculitis2015
Author(s)
Kajiyama H, Hiromura K, Lkuma D, Suwa J, Ikenouchi H, Kurosawa H, Hirayama Y, Hara M, Saito A, Nojima Y, Miura T
Organizer
48th Annual Meeting of American Society of Nephrology
Place of Presentation
San Diego Convention Center(San Diego, USA)
Year and Date
2015-11-03
Related Report
Int'l Joint Research
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[Presentation] Reduction of Albuminuria by Sitagliptin Is Associated with Improvement of Renal Proximal Tubular Function in Patients with Type 2 Diabetes2015
Author(s)
Hosojima M, Sasagawa T, Kabasawa H, Ishikawa T, Kaseda R, Suzuki Y, Narita I, Kurosawa H, Hirayama Y, Saito A
Organizer
American Diabetes Association’s 75th Scientific Sessions
Place of Presentation
New Orleans Ernest N. Morial Convention Center(Boston, USA)
Year and Date
2015-06-05
Related Report
Int'l Joint Research
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