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Analysis of factors related to the development and progression of vascular lesions in patients with autosomal dominant polycystic kidney disease

Research Project

Project/Area Number 26461217
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKanazawa University

Principal Investigator

Yamada Kazunori  金沢大学, 医薬保健学総合研究科, 特任准教授 (90397224)

Co-Investigator(Kenkyū-buntansha) 川野 充弘  金沢大学, 附属病院, 講師 (20361983)
山岸 正和  金沢大学, 医学系, 教授 (70393238)
小野江 為人  金沢大学, 医学系, 協力研究員 (80603498)
川尻 剛照  金沢大学, 医学系, 准教授 (90345637)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords多発性嚢胞腎 / 血管病変 / 常染色体劣性多発性嚢胞腎 / 脳動脈瘤 / 絨毛
Outline of Final Research Achievements

We retrospectively analyzed brain and cardiovascular lesions in patients with autosomal dominant polycystic kidney disease (ADPKD) undergoing hemodialysis. We observed that the prevalence of cerebral aneurysms, cerebral infarction, and mitral regurgitation in this population was 40.7, 55.6, and 66.7%, respectively, indicating that these patients require periodic evaluation after the initiation of dialysis. Furthermore, we investigated the effectiveness of tolvaptan in patients with ADPKD.
The efficacy and adverse effects of tolvaptan are similar in patients with chronic kidney disease (CKD) stages G4 and G2-G3b, which indicates that tolvaptan is effective even in patients with low renal function. Tolvaptan does not directly affect the vascular system; however, by delaying the timing of initiation of dialysis, it may indirectly affect the vascular system.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing2017

    • Author(s)
      Numata Tomohiro、Tsumoto Kunichika、Yamada Kazunori、Kurokawa Tatsuki、Hirose Shinichi、Nomura Hideki、Kawano Mitsuhiro、Kurachi Yoshihisa、Inoue Ryuji、Mori Yasuo
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 9760-9760

    • DOI

      10.1038/s41598-017-10357-3

    • NAID

      120006364088

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hints to the diagnosis of uromodulin kidney disease.2016

    • Author(s)
      Onoe T, Yamada K, Mizushima I, Ito K, Kawakami T, Daimon S, Muramoto H, Konoshita T, Yamagishi M, Kawano M.
    • Journal Title

      Clin Kidney J

      Volume: 9 Issue: 1 Pages: 69-75

    • DOI

      10.1093/ckj/sfv110

    • NAID

      120006325348

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case developing minimal change disease during the course of IgG4-related disease.2015

    • Author(s)
      Yamada K, Zoshima T, Ito K, Mizushima I, Hara S, Horita S, Nuka H, Hamano R, Fujii H, Yamagishi M, Kawano M.
    • Journal Title

      Mod Rheumatol

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] The usefulness of tolvaptan in patients with autosomal dominant polycystic kidney disease with chronic kidney disease stage G3 to G42016

    • Author(s)
      Kazunori Yamada, Hiroaki Muramoto, Hideo Araki, Yasushi Kakuchi, Kyoko Miyagi, Susumu Kitajima, Yukiko Tani, Tamehito Onoe, Masayoshi Hirata, Masahiro Takeda, Ryoichi Miyazaki, and Mitsuhiro Kawano
    • Organizer
      53rd ERA-EDTA Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-06-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 常染色体優性多発性嚢胞腎に対するトルバプタン投与例の検討2016

    • Author(s)
      山田和徳,村本弘昭,荒木英雄,覚知泰志,宮城恭子,北島進,谷悠紀子,小野江為人,平田昌義,竹田正廣,宮崎良一,川野充弘
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 山田和徳、村本弘昭、荒木英雄、覚知泰志、宮城恭子、北島進、谷悠紀子、小野江為人、平田昌義、竹田正廣、宮崎良一、川野充弘2016

    • Author(s)
      常染色体優性多発性嚢胞腎に対するトルバプタン投与例の検討
    • Organizer
      第59回日本腎臓学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2015 Research-status Report
  • [Presentation] The usefulness of tolvaptan in patients with autosomal dominant polycystic kidney disease with chronic kidney disease stage G3 to G4.2016

    • Author(s)
      Yamada K, Muramoto H, Araki H, Kakuchi Y, Miyagi K, Kitajima S, Tani Y, Onoe T, Hirata M, Takeda M, Miyazaki R, Kawano M.
    • Organizer
      European Renal Association/European Dialysis and Transplant Association 2016 53th Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-05-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Decreased serum uromodulin concentration is a specific characteristic in uromodulin kidney disease.2016

    • Author(s)
      Onoe T, Yamada K, Muramoto H, Kawano M.
    • Organizer
      European Renal Association/European Dialysis and Transplant Association 2016 53th Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-05-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical analysis of restless legs syndrome in long-term Japanese hemodialysis patients2014

    • Author(s)
      Kazunori Yamada, Toru Shibata, Toshiaki Kimura, Tsutomu Matsushima, Remon Otake, Akira Junicho, Masatsune Hasegawa, Mitsuhiro Kawano, Toru Hasegawa
    • Organizer
      Kidney Week 2014
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 透析患者におけるレストレスレッグス症候群の臨床的検討2014

    • Author(s)
      山田和徳、柴田透、木村俊明、松島勉、大武礼文、十二町明、長谷川眞常、川野充弘、長谷川徹
    • Organizer
      第59回日本透析医学会学術集会・総会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2014-06-12 – 2014-06-15
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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