Analysis of factors related to the development and progression of vascular lesions in patients with autosomal dominant polycystic kidney disease

• Project/Area Number: 26461217
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: Yamada Kazunori 金沢大学, 医薬保健学総合研究科, 特任准教授 (90397224)
• Co-Investigator(Kenkyū-buntansha): 川野 充弘 金沢大学, 附属病院, 講師 (20361983) ; 山岸 正和 金沢大学, 医学系, 教授 (70393238) ; 小野江 為人 金沢大学, 医学系, 協力研究員 (80603498) ; 川尻 剛照 金沢大学, 医学系, 准教授 (90345637)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 多発性嚢胞腎 / 血管病変 / 常染色体劣性多発性嚢胞腎 / 脳動脈瘤 / 絨毛

Outline of Final Research Achievements

We retrospectively analyzed brain and cardiovascular lesions in patients with autosomal dominant polycystic kidney disease (ADPKD) undergoing hemodialysis. We observed that the prevalence of cerebral aneurysms, cerebral infarction, and mitral regurgitation in this population was 40.7, 55.6, and 66.7%, respectively, indicating that these patients require periodic evaluation after the initiation of dialysis. Furthermore, we investigated the effectiveness of tolvaptan in patients with ADPKD.
The efficacy and adverse effects of tolvaptan are similar in patients with chronic kidney disease (CKD) stages G4 and G2-G3b, which indicates that tolvaptan is effective even in patients with low renal function. Tolvaptan does not directly affect the vascular system; however, by delaying the timing of initiation of dialysis, it may indirectly affect the vascular system.

Research Products

• [Journal Article] Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing (2017)
  • Author(s): Numata Tomohiro、Tsumoto Kunichika、Yamada Kazunori、Kurokawa Tatsuki、Hirose Shinichi、Nomura Hideki、Kawano Mitsuhiro、Kurachi Yoshihisa、Inoue Ryuji、Mori Yasuo
  • Journal Title: Sci. Rep. Volume: 7 Issue: 1 Pages: 9760-9760
  • DOI: 10.1038/s41598-017-10357-3
  • NAID: 120006364088
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hints to the diagnosis of uromodulin kidney disease. (2016)
  • Author(s): Onoe T, Yamada K, Mizushima I, Ito K, Kawakami T, Daimon S, Muramoto H, Konoshita T, Yamagishi M, Kawano M.
  • Journal Title: Clin Kidney J Volume: 9 Issue: 1 Pages: 69-75
  • DOI: 10.1093/ckj/sfv110
  • NAID: 120006325348
  • Peer Reviewed
• [Journal Article] A case developing minimal change disease during the course of IgG4-related disease. (2015)
  • Author(s): Yamada K, Zoshima T, Ito K, Mizushima I, Hara S, Horita S, Nuka H, Hamano R, Fujii H, Yamagishi M, Kawano M.
  • Journal Title: Mod Rheumatol Volume: 印刷中
  • Peer Reviewed
• [Presentation] The usefulness of tolvaptan in patients with autosomal dominant polycystic kidney disease with chronic kidney disease stage G3 to G4 (2016)
  • Author(s): Kazunori Yamada, Hiroaki Muramoto, Hideo Araki, Yasushi Kakuchi, Kyoko Miyagi, Susumu Kitajima, Yukiko Tani, Tamehito Onoe, Masayoshi Hirata, Masahiro Takeda, Ryoichi Miyazaki, and Mitsuhiro Kawano
  • Organizer: 53rd ERA-EDTA Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-06-21
  • Int'l Joint Research
• [Presentation] 常染色体優性多発性嚢胞腎に対するトルバプタン投与例の検討 (2016)
  • Author(s): 山田和徳，村本弘昭，荒木英雄，覚知泰志，宮城恭子，北島進，谷悠紀子，小野江為人，平田昌義，竹田正廣，宮崎良一，川野充弘
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-17
• [Presentation] 山田和徳、村本弘昭、荒木英雄、覚知泰志、宮城恭子、北島進、谷悠紀子、小野江為人、平田昌義、竹田正廣、宮崎良一、川野充弘 (2016)
  • Author(s): 常染色体優性多発性嚢胞腎に対するトルバプタン投与例の検討
  • Organizer: 第59回日本腎臓学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-17
• [Presentation] The usefulness of tolvaptan in patients with autosomal dominant polycystic kidney disease with chronic kidney disease stage G3 to G4. (2016)
  • Author(s): Yamada K, Muramoto H, Araki H, Kakuchi Y, Miyagi K, Kitajima S, Tani Y, Onoe T, Hirata M, Takeda M, Miyazaki R, Kawano M.
  • Organizer: European Renal Association/European Dialysis and Transplant Association 2016 53th Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] Decreased serum uromodulin concentration is a specific characteristic in uromodulin kidney disease. (2016)
  • Author(s): Onoe T, Yamada K, Muramoto H, Kawano M.
  • Organizer: European Renal Association/European Dialysis and Transplant Association 2016 53th Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] Clinical analysis of restless legs syndrome in long-term Japanese hemodialysis patients (2014)
  • Author(s): Kazunori Yamada, Toru Shibata, Toshiaki Kimura, Tsutomu Matsushima, Remon Otake, Akira Junicho, Masatsune Hasegawa, Mitsuhiro Kawano, Toru Hasegawa
  • Organizer: Kidney Week 2014
  • Place of Presentation: Philadelphia, U.S.A.
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] 透析患者におけるレストレスレッグス症候群の臨床的検討 (2014)
  • Author(s): 山田和徳、柴田透、木村俊明、松島勉、大武礼文、十二町明、長谷川眞常、川野充弘、長谷川徹
  • Organizer: 第59回日本透析医学会学術集会・総会
  • Place of Presentation: 神戸ポートピアホテル（神戸）
  • Year and Date: 2014-06-12 – 2014-06-15