| Project/Area Number |
26461222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
Suzuki Yasuhiro 名古屋大学, 医学系研究科, 寄附講座助教 (20584676)
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| Co-Investigator(Kenkyū-buntansha) |
水野 正司 名古屋大学, 医学系研究科, 寄附講座准教授 (20303638)
坂田 史子 名古屋大学, 医学系研究科, 特任助教 (20726484)
伊藤 恭彦 名古屋大学, 医学系研究科, 寄附講座教授 (60402632)
松尾 清一 名古屋大学, 医学系研究科, 教授 (70190410)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | CKD / 心腎連関 / バイオマーカー / 心線維化 / 慢性腎臓病 / 心肥大 / メタボローム解析 / バイマーカー |
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| Outline of Final Research Achievements |
We searched new biomarkers of cardio-renal syndrome in a mouse model with CKD. Some possible candidate substances reflecting CKD-related pathogenic changes in heart such as fibrosis were identified by metabolomics. The candidate substances were confirmed other animal models and in vitro experiments with a rat fibroblast cell line. When we also investigated serum candidate substances and echocardiography examinations in patients on peritoneal dialysis at our hospital, a significant correlation between the candidate substances and cardiac hypertrophy indicators were observed (P = 0.001, R2 = 0.25). It was suggested that some of our identified substances might play roles as new biomarkers to predict progress of cardiac fibrosis in patients with CKD.
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