| Project/Area Number |
26461224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森 潔 静岡県立大学, 薬学部, 特任教授 (60343232)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | バイオマーカー / 腎障害 / 栄養 / 肥満 / 血液透析 / 感染症 / メガリン / 褐色脂肪 / 腎不全 / リポカリン / 鉄 / 交感神経系 / 透析 / 感染 / アルブミン / 好中球 |
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| Outline of Final Research Achievements |
Among maintenance hemodialysis patients, serum NGAL levels were elevated by 13-fold compared to healthy subjects. In hemodialysis patients with low serum NGAL levels, serum albumin levels were significantly reduced after a year, and such patients showed a tendency to develop severe infection requiring admission. In drug-inducible megalin knockout mice, renal protein reabsorption was completely inhibited in the absence of tubular cell death, and urinary NGAL excretion was increased by 800-fold. In NGAL knockout mice, brown adipose tissue was more intensely activated by high fat diet treatment or by cold exposure compared to control mice, and body weight gain or body temperature loss was inhibited. NGAL was a novel circulating factor induced in white adipose tissues by obesity, which plays a positive feedback role to enhance obesity.
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