A Role of NGAL in Renal Injury and Energy Metabolism
Project/Area Number |
26461224
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Kyoto University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
森 潔 静岡県立大学, 薬学部, 特任教授 (60343232)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | バイオマーカー / 腎障害 / 栄養 / 肥満 / 血液透析 / 感染症 / メガリン / 褐色脂肪 / 腎不全 / リポカリン / 鉄 / 交感神経系 / 透析 / 感染 / アルブミン / 好中球 |
Outline of Final Research Achievements |
Among maintenance hemodialysis patients, serum NGAL levels were elevated by 13-fold compared to healthy subjects. In hemodialysis patients with low serum NGAL levels, serum albumin levels were significantly reduced after a year, and such patients showed a tendency to develop severe infection requiring admission. In drug-inducible megalin knockout mice, renal protein reabsorption was completely inhibited in the absence of tubular cell death, and urinary NGAL excretion was increased by 800-fold. In NGAL knockout mice, brown adipose tissue was more intensely activated by high fat diet treatment or by cold exposure compared to control mice, and body weight gain or body temperature loss was inhibited. NGAL was a novel circulating factor induced in white adipose tissues by obesity, which plays a positive feedback role to enhance obesity.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.2017
Author(s)
Mori KP, Yokoi H, Kasahara M, Imamaki H, Ishii A, Kuwabara T, Koga K, Kato Y, Toda N, Ohno S, Kuwahara K, Endo T, Nakao K, Yanagita M, Mukoyama M, Mori K.
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Journal Title
J Am Soc Nephrol.
Volume: 28
Issue: 1
Pages: 278-289
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Urinary Albumin Levels Predict Development of Acute Kidney Injury After Pediatric Cardiac Surgery: A Prospective Observational Study.2016
Author(s)
Sugimoto K, Toda Y, Iwasaki T, Shimizu K, Kanazawa T, Muto N, Kawase H, Morimatsu H, Morita K, Maeshima Y, Mori K, Sano S.
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Journal Title
J Cardiothorac Vasc Anesth
Volume: 30
Issue: 1
Pages: 64-68
DOI
Related Report
Peer Reviewed
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[Journal Article] Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients.2015
Author(s)
Imamaki H, Ishii A, Yokoi H, Kasahara M, Kuwabara T, Mori KP, Kato Y, Kuwahara T, Satoh M, Nakatani K, Saito Y, Tomosugi N, Sugawara A, Nakao K, Mukoyama M, Yanagita M, Mori K.
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Journal Title
PLoS One
Volume: 10
Issue: 7
Pages: 99-106
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 褐色脂肪での熱産生・FDG取り込みに対する 鉄輸送蛋白NGALの抑制効果とメカニズム2016
Author(s)
石井 輝,今牧 博貴,勝浦 五郎,木村 寛之,中本 裕士,森 慶太,桒原 孝成,横井 秀基, 笠原 正登,中尾 一和,柳田 素子,向山 政志,森 潔
Organizer
第59回日本糖尿病学会年次学術集会
Place of Presentation
京都
Year and Date
2016-05-19
Related Report
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[Presentation] 褐色脂肪での熱産生・FDG取り込みに対する 鉄輸送蛋白NGALの抑制効果とメカニズム2016
Author(s)
石井輝,今牧博貴,勝浦五郎,木村寛之,中本裕士,森慶太,桒原孝成,横井秀基, 笠原正登,中尾一和,柳田素子,向山政志,森潔
Organizer
日本糖尿病学会年次学術集会
Place of Presentation
京都
Year and Date
2016-05-19
Related Report
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[Presentation] Prediction of Changes in Serum Albumin Levels among Hemodialysis Patients by Serum Neutrophil Gelatinase-Associated Lipocalin Levels.2015
Author(s)
Hirotaka Imamaki, Akira Ishii, Hideki Yokoi, Masato Kasahara, Keita P. Mori, Takashige Kuwabara, Kazuwa Nakao, Masashi Mukoyama, Motoko Yanagita, Kiyoshi Mori
Organizer
Annual Meeting of the American Society of Nephrology
Place of Presentation
San Diego, USA
Year and Date
2015-11-05
Related Report
Int'l Joint Research
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[Presentation] Novel drug-inducible megalin knockout mice reveal marked increase of both total nephron glomerular filtration and tubular reabsorption of albumin in early diabetic nephropathy.2015
Author(s)
Keita P. Mori, Hideki Yokoi, Masato Kasahara, Takashige Kuwabara, Hirotaka Imamaki, Akira Ishii, Kazuwa Nakao, Tomomi Endo, Motoko Yanagita, Masashi Mukoyama, Kiyoshi Mori
Organizer
Annual Meeting of the American Society of Nephrology
Place of Presentation
San Diego, USA
Year and Date
2015-11-05
Related Report
Int'l Joint Research
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[Presentation] 慢性維持血液透析患者において現在および将来の血清アルブミン濃度を予測する指標2015
Author(s)
森潔, 今牧博貴, 石井輝, 森慶太, 横井秀基, 笠原正登, 桑原孝成, 桑原隆, 佐藤眞杉, 菅原照, 向山政志, 柳田素子
Organizer
日本透析医学会学術集会
Place of Presentation
横浜
Year and Date
2015-06-26
Related Report
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[Presentation] Low Serum Neutrophil Gelatinase-Associated Lipocalin Level as a Malnutrition Marker in Hemodialysis Patients.2014
Author(s)
Hirotaka Imamaki, Akira Ishii, Hideki Yokoi, Masato Kasahara, Takashige Kuwabara, Keita P. Mori, Yukiko Kato, Akira Sugawara, Kazuwa Nakao, Motoko Yanagita, Masashi Mukoyama, Kiyoshi Mori.
Organizer
Annual Meeting of the American Society of Nephrology.
Place of Presentation
Pennsylvania, USA
Year and Date
2014-11-13 – 2014-11-16
Related Report
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[Presentation] 健常人及び腎不全症例における血中・尿中NGALの分子量の違い2014
Author(s)
今牧博貴, 森潔, 森慶太, 石井輝, 桑原孝成, 笠原正登, 横井秀基, 古賀健一, 加藤有希子, 戸田尚宏, 大野祥子, 中尾一和, 菅原照, 柳田素子, 向山政志
Organizer
日本腎臓学会
Place of Presentation
横浜
Year and Date
2014-07-04 – 2014-07-06
Related Report
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[Presentation] 臨床現場における尿中NGALの実用性2014
Author(s)
瀬川裕佳, 薗村和宏, 江川雅弘, 上野里紗, 原将之, 大谷麻衣, 川崎由佳, 鶴田宏史, 鯉堂和宏, 森潔, 八田告
Organizer
滋賀腎・透析研究会
Place of Presentation
滋賀
Year and Date
2014-06-20
Related Report
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[Presentation] 分泌シグナルNgalの糖脂質代謝における意義2014
Author(s)
石井輝, 今牧博貴, 桑原孝成, 笠原正登, 横井秀基, 古賀健一, 森慶太, 加藤有希子, 戸田尚宏, 大野祥子, 菅原照, 柳田素子, 中尾一和, 向山政志, 森潔
Organizer
糖尿病学会
Place of Presentation
大阪
Year and Date
2014-05-22 – 2014-05-24
Related Report
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