Roles of humoral factors and organ-organ or cell-cell communications in the development and progression of metabolic kidney diseases

• Project/Area Number: 26461226
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: MUKOYAMA Masashi 熊本大学, 大学院生命科学研究部(医), 教授 (40270558)
• Co-Investigator(Renkei-kenkyūsha): MORI Kiyoshi 静岡県立大学, 薬学部, 特任教授 (60343232)
• Research Collaborator: KUWABARA Takashige 熊本大学, 大学院生命科学研究部, 助教 (00393356)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 腎臓学 / 内分泌学 / メタボリック症候群 / 糖尿病性腎症 / レニン・アンジオテンシン系 / ナトリウム利尿ペプチド / N型カルシウムチャネル / 自然炎症 / 高血圧 / アルドステロン / マクロファージ / metabolic syndrome / 肥満症 / renin-angiotensin system

Outline of Final Research Achievements

Lifestyle-related noncommunicable diseases such as diabetes, obesity and hypertension are the major risk for metabolic kidney diseases, in which endocrine dysregulation in organ-organ or cell-cell communications in the kidney may be suggested. We investigated roles of humoral factors in this pathophysiology.
We found that the natriuretic peptide (ANP and BNP) receptor GC-A in podocytes is important in protecting against aldosterone-induced glomerular injury in mice. We also found the role of N-type calcium channels in sympathetic nerve activation and podocyte injury in obese diabetic mice with nephropathy. Finally, we found the pathogenic role of local homeostatic inflammation driven by toll-like receptor 4 and its endogenous ligand myeloid-related protein 8 (MRP8), a macrophage-derived proinflammatory factor, in mouse models of diabetes-hyperlipidemia as well as proliferative nephritis. These findings may provide potential therapeutic strategies for metabolic kidney diseases.

Research Products

• [Int'l Joint Research] University of Bristol(United Kingdom)
• [Int'l Joint Research] University of Bristol(United Kingdom)
• [Int'l Joint Research] National Heart, Lung and Blood Institute(米国)
• [Journal Article] Production and analysis of conditional KO mice of CCN2 in kidney. (2017)
  • Author(s): N. Toda, H. Yokoi, K. Mori, M. Mukoyama
  • Journal Title: Methods in Molecular Biology Volume: 1489 Pages: 377-390
  • DOI: 10.1007/978-1-4939-6430-7_31
  • ISBN: 9781493964284, 9781493964307
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Analysis of pathological activities of CCN proteins in fibrotic diseases: Kidney fibrosis. (2017)
  • Author(s): H. Yokoi, M. Mukoyama
  • Journal Title: Methods in Molecular Biology Volume: 1489 Pages: 431-443
  • DOI: 10.1007/978-1-4939-6430-7_36
  • ISBN: 9781493964284, 9781493964307
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy. (2017)
  • Author(s): Mori KP, Yokoi H, Kasahara M, Imamaki H, Ishii A, Kuwabara T, Koga K, Kato Y, Toda N, Ohno S, Kuwahara K, Endo T, Nakao K, Yanagita M, Mukoyama M, Mori K.
  • Journal Title: J Am Soc Nephrol. Volume: 28 Issue: 1 Pages: 278-289
  • DOI: 10.1681/asn.2015101168
  • NAID: 120005820888
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Crucial role of mesangial cell-derived connective tissue growth factor in a mouse model of anti-glomerular basement membrane glomerulonephritis. (2017)
  • Author(s): Toda N, Mori K, Kasahara M, Ishii A, Koga K, Ohno S, Mori KP. Kato Y, Osaki K, Kuwabara T, Kojima K, Taura D, Sone M, Matsusaka T, Nakao K, Mukoyama M, Yanagita M, Yokoi H.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 42114-42114
  • DOI: 10.1038/srep42114
  • NAID: 120005997757
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition. (2017)
  • Author(s): Y. Kato, K. Mori, M. Kasahara, K. Osaki, A. Ishii, K.P. Mori, N. Toda, S. Ohno, T. Kuwabara, T. Tokudome, I. Kishimoto, M.A. Saleem, T. Matsusaka, K. Nakao, M. Mukoyama, M. Yanagita, H. Yokoi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 46624-46624
  • DOI: 10.1038/srep46624
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes. (2017)
  • Author(s): Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H.
  • Journal Title: Nephrol Dial Transplant. Volume: 未定 Issue: 9 Pages: 000-000
  • DOI: 10.1093/ndt/gfw463
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure. (2016)
  • Author(s): Ohno S, Yokoi H, Mori K, Kasahara M, Kuwahara K, Fujikura J, Naito M, Kuwabara T, Imamaki H, Ishii A, Saleem MA, Numata T, Mori Y, Nakao K, Yanagita M, Mukoyama M
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 27192-27192
  • DOI: 10.1038/srep27192
  • NAID: 120007100128
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Human induced pluripotent stem cell-derived podocytes mature into vascularized glomeruli upon experimental transplantation. (2016)
  • Author(s): Sharmin S, Taguchi A, Kaku Y, Yoshimura Y, Ohmori T, Sakuma T, Mukoyama M, Yamamoto T, Kurihara H, Nishinakamura R
  • Journal Title: J Am Soc Nephrol Volume: 27 Issue: 6 Pages: 1778-1791
  • DOI: 10.1681/asn.2015010096
  • Peer Reviewed / Open Access
• [Journal Article] Mild systemic thermal therapy ameliorates renal dysfunction in a rodent model of chronic kidney disease. (2016)
  • Author(s): Iwashita Y, Kuwabara T, Hayata M, Kakizoe Y, Izumi Y, Iiyama J, Kitamura K, Mukoyama M.
  • Journal Title: Am J Physiol Renal Physiol. Volume: in press Issue: 11 Pages: 1-1
  • DOI: 10.1152/ajprenal.00519.2015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity. (2016)
  • Author(s): Y. Kakizoe, Y. Miyasato, T. Onoue, T. Nakagawa, M. Hayata, K. Uchimura, J. Morinaga, T. Mizumoto, M. Adachi, T. Miyoshi, Y. Sakai, K. Tomita, M. Mukoyama, K. Kitamura
  • Journal Title: Journal of Pharmacological Sciences Volume: 132 Issue: 2 Pages: 145-153
  • DOI: 10.1016/j.jphs.2016.09.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Angiopoietin-like protein 2 increases renal fibrosis by accelerating transforming growth factor-β signaling in chronic kidney disease. (2016)
  • Author(s): Jun Morinaga, Tsuyoshi Kadomatsu, Keishi Miyata, Motoyoshi Endo, Kazutoyo Terada, Zhe Tian, Taichi Sugizaki, Hiroki Tanigawa, Jiabin Zhao, Shunshun Zhu, Michio Sato, Kimi Araki, Ken-ichi Iyama, Kengo Tomita, Masashi Mukoyama, Kimio Tomita, Kenichiro Kitamura, Yuichi Oike
  • Journal Title: Kidney International Volume: 89 Issue: 2 Pages: 327-341
  • DOI: 10.1016/j.kint.2015.12.021
  • Peer Reviewed
• [Journal Article] Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model. (2016)
  • Author(s): Yuki Narita, Miki Ueda, Kohei Uchimura, Yutaka Kakizoe, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Terumasa Nakagawa, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Daisuke Kadowaki, Sumio Hirata, Masashi Mukoyama, Kenichiro Kitamura
  • Journal Title: Journal of Pharmacological Sciences Volume: 130 Issue: 2 Pages: 110-116
  • DOI: 10.1016/j.jphs.2016.01.003
  • Peer Reviewed / Open Access
• [Journal Article] Peptide affinity analysis of proteins that bind to an unstructured NH2-terminal region of the osmoprotective transcription factor NFAT5. (2016)
  • Author(s): Jenna F. DuMond, Kevin Ramkissoon, Xue Zhang, Yuichiro Izumi, Xujing Wang, Koji Eguchi, Shouguo Gao, Masashi Mukoyama, Maurice B. Burg, Joan D. Ferraris
  • Journal Title: Physiological Genomics Volume: 48 Issue: 4 Pages: 290-305
  • DOI: 10.1152/physiolgenomics.00110.2015
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] MicroRNA-26a inhibits TGF-β-induced extracellular matrix expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy. (2015)
  • Author(s): Koga K, Yokoi H, Mori K, Kasahara K, Kuwabara T, Imamaki H, Ishii A, Mori KP, Kato Y, Ohno S, Toda N, Saleem MA, Sugawara A, Nakao K, Yanagita M, Mukoyama M.
  • Journal Title: Diabetologia Volume: 58 Issue: 9 Pages: 2169-80
  • DOI: 10.1007/s00125-015-3642-4
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients. (2015)
  • Author(s): Imamaki H, Ishii A, Yokoi H, Kasahara M, Kuwabara T, Mori KP, Kato Y, Kuwahara T, Satoh M, Nakatani K, Saito Y, Tomosugi N, Sugawara A, Nakao K, Mukoyama M, Yanagita M, Mori K.
  • Journal Title: PLoS One Volume: 10 Issue: 7 Pages: 99-106
  • DOI: 10.1371/journal.pone.0132539
  • NAID: 120005678176
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reduction of Tubular Flow Rate as a Mechanism of Oliguria in the Early Phase of Endotoxemia Revealed by Intravital Imaging. (2015)
  • Author(s): Nakano D, Doi K, Kitamura H, Kuwabara T, Mori K, Mukoyama M, Nishiyama A.
  • Journal Title: J Am Soc Nephrol Volume: 26 Issue: 12 Pages: 3035-44
  • DOI: 10.1681/asn.2014060577
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An AKI biomarker lipocalin 2 in the blood derives from the kidney in renal injury but from neutrophils in normal and infected conditions. (2015)
  • Author(s): Kanda J, Mori K, Kawabata H, Kuwabara T, Mori KP, Imamaki H, Kasahara M, Yokoi H, Mizumoto C, Thoennissen NH, Koeffler HP, Barasch J, Takaori-Kondo A, Mukoyama M, Nakao K.
  • Journal Title: Clin Exp Nephrol. Volume: 19 Issue: 1 Pages: 99-106
  • DOI: 10.1007/s10157-014-0952-7
  • NAID: 120005678175
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects. (2015)
  • Author(s): Miki Ueda, Kohei Uchimura, Yuki Narita, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Yutaka Kakizoe, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Daisuke Kadowaki, Y Sakai, Masashi Mukoyama, Kenichiro Kitamura
  • Journal Title: Nephron Volume: 129 Issue: 3 Pages: 223-232
  • DOI: 10.1159/000375308
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Macrophage-mediated glucolipotoxicity via myeloid-related protein 8/toll-like receptor 4 signaling in diabetic nephropathy (2014)
  • Author(s): Kuwabara, T., Mori, K., Mukoyama, M., Kasahara, M., Yokoi, H., Nakao, K.
  • Journal Title: Clinical and Experimental Nephrology Volume: impress Issue: 4 Pages: 584-592
  • DOI: 10.1007/s10157-013-0922-5
  • NAID: 120005474441
  • Peer Reviewed
• [Journal Article] Reevaluation of erythropoietin production by the nephron (2014)
  • Author(s): Nagai T, Yasuoka Y, Kawahara K, Nonoguchi H, et al.
  • Journal Title: Biochem Biophys Res Commun. Volume: 449 Issue: 3 Pages: 222-228
  • DOI: 10.1016/j.bbrc.2014.09.089
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Matrix metalloproteinase-10 in glomeruli of aldosterone-infused systemic and podocyte-specific guanylyl cyclase-A knockout mice. (2016)
  • Author(s): Keisuke Osaki
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Deletion of sirtuin 7 ameliorates cisplatin-induced acute kidney injury through regulation of inflammatory response. (2016)
  • Author(s): Yoshikazu Miyasato
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Intraglomerular crosstalk between mesangial cells and macrophages in glomerular injury. (2016)
  • Author(s): Shuro Umemoto
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Myeloid-specific deletion of MRP8 ameliorates glomerulonephritis through affecting macrophage characterization. (2016)
  • Author(s): Takashige Kuwabara
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] In silico and in vitro characterization of low pH-induced genes in intercalated cells of the collecting ducts. (2016)
  • Author(s): Yuichiro Izumi
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Involvement of aldosterone and the ubiquitin-proteasome system in the regulation of expression of an ammonia transporter, rhesus blood group C glycoprotein, in the intercalated cells. (2016)
  • Author(s): Koji Eguchi
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] A serine protease inhibitor increases osmotic free water excretion together with suppressed urinary exosomal AQP2 excretion. (2016)
  • Author(s): Yutaka Kakizoe
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Doxycycline ameliorates cisplatin-induced nephrotoxicity in mice through directly acting on proximal tubular cells and promoting cell viability. (2016)
  • Author(s): Terumasa Nakagawa
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] 降圧治療から臓器保護を目指した治療へ：新たな降圧薬としてのARNiの可能性 (2016)
  • Author(s): 向山政志
  • Organizer: 第39回日本高血圧学会総会
  • Place of Presentation: 仙台国際センター, 仙台
  • Year and Date: 2016-09-30
  • Invited
• [Presentation] Glomerular MRP8 expression predicts progression of proteinuria in obese or type 2 diabetic patients. (2016)
  • Author(s): Takashige Kuwabara
  • Organizer: 26th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] The role of activated renin-angiotensin system for the MRP8/TLR4 signaling in diabetic nephropathy. (2016)
  • Author(s): Shuro Umemoto
  • Organizer: 26th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Computational analysis of the effects of aldosterone and metabolic acidosis on gene expressions in renal tubules. (2016)
  • Author(s): Yuichiro Izumi
  • Organizer: 26th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Aldosterone modulates expression of an acid-secreting ammonia transporter Rhcg in intercalated cells of the collecting ducts. (2016)
  • Author(s): Koji Eguchi
  • Organizer: 26th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] A serine protease inhibitor increases osmotic free water excretion in normal rats. (2016)
  • Author(s): Yutaka Kakizoe
  • Organizer: 26th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Serine protease inhibition attenuates salt-sensitive hypertension and podocyte injury in a rat model of metabolic syndrome. (2016)
  • Author(s): Yutaka Kakizoe
  • Organizer: 26th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Activation of the renin-angiotensin system in diabetic nephropathy induces local inflammation through intraglomerular crosstalk. (2016)
  • Author(s): Takashige Kuwabara
  • Organizer: 15th Asian Pacific Congress of Nephrolgy
  • Place of Presentation: Perth Convention and Exhibition Centre, Perth, Australia
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] Microalbuminuric stage of diabetic nephropathy is characterized with enhancement of total nephron albumin filtration and reabsorption. (2016)
  • Author(s): Keita P. Mori
  • Organizer: 15th Asian Pacific Congress of Nephrolgy
  • Place of Presentation: Perth Convention and Exhibition Centre, Perth, Australia
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] 新たな降圧薬としてのangiotensin receptor-neprilysin inhibitor (ARNi) (2016)
  • Author(s): 向山政志
  • Organizer: 第5回臨床高血圧フォーラム
  • Place of Presentation: ステーションコンファレンス東京, 東京
  • Year and Date: 2016-05-14
  • Invited
• [Presentation] Role of the N-type calcium channel in a mouse model of diabetic nephropathy. (2015)
  • Author(s): Shoko Ohno
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Novel drug-inducible megalin knockout mice reveal marked increase of both total nephron glomerular filtration and tubular reabsorption of albumin in early diabetic nephropathy. (2015)
  • Author(s): Keita P. Mori
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Prediction of changes in serum albumin levels among hemodialysis patients by serum neutrophil gelatinase-associated lipocalin levels. (2015)
  • Author(s): Hirotaka Imamaki
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] The protective role of doxycycline for cisplatin-induced AKI by its anti-inflammatory and anti-oxidative effects. (2015)
  • Author(s): Terumasa Nakagawa
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] HIF1a and HIGF2-induced erythropoietin production along the nephron. (2015)
  • Author(s): Yuichiro Izumi
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] TSS-Seq analysis of low pH-induced gene transcripts in the intercalated cells of the collecting ducts. (2015)
  • Author(s): Yuichiro Izumi
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Regulation of Rhcg by aldosterone in intercalated cells of the collecting ducts. (2015)
  • Author(s): Koji Eguchi
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Na調節の考え方と循環調節ホルモン (2015)
  • Author(s): 向山政志
  • Organizer: 第45回日本腎臓学会西部学術大会
  • Place of Presentation: 金沢歌劇座, 金沢
  • Year and Date: 2015-10-24
  • Invited
• [Presentation] 循環調節ホルモンと臓器連関 (2015)
  • Author(s): 向山政志
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: ひめぎんホール, 松山
  • Year and Date: 2015-10-11
  • Invited
• [Presentation] 心腎代謝連関と心臓血管ホルモン (2015)
  • Author(s): 向山政志
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: ホテルニューオータニ東京, 東京
  • Year and Date: 2015-04-23
  • Invited
• [Presentation] Kidney myeloid-related protein 8 expression predicts renal prognosis in obese or type 2 diabetic patients. (2015)
  • Author(s): Takashige Kuwabara
  • Organizer: The World Congress of Nephrology 2015
  • Place of Presentation: Cape Town International Convention Centre, Cape Town, South Africa
  • Year and Date: 2015-03-14
• [Presentation] Role of the natriuretic peptide GC-A receptor on podocytes in aldosterone-induced glomerular injury. (2014)
  • Author(s): Yukiko Kato
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, USA
  • Year and Date: 2014-11-14
• [Presentation] The role of mesangial cell-derived CTGF in anti-glomerular basement membrane nephritis. (2014)
  • Author(s): Naohiro Toda
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, USA
  • Year and Date: 2014-11-13
• [Presentation] Glomerular microRNA-26a expression correlates with eGFR in diabetic nephropathy and its regulation in podocytes. (2014)
  • Author(s): Kenichi Koga
  • Organizer: Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, USA
  • Year and Date: 2014-11-13
• [Presentation] 高血圧・腎臓病におけるNa利尿ペプチド系と臓器連関 (2014)
  • Author(s): 向山政志
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-10-19
  • Invited
• [Presentation] Role of N-type calcium channel in diabetic nephropathy. (2014)
  • Author(s): Masashi Mukoyama
  • Organizer: Joint Meeting of the European Society of Hypertension and the International Society of Hypertension
  • Place of Presentation: Megaron Athens International Conference Centre, Athens, Greece
  • Year and Date: 2014-06-15
• [Presentation] Inhibition of p38 MAP kinase ameliorates aldosterone-induced podocyte injury in natriuretic peptide receptor (GC-A)-deficient mice. (2014)
  • Author(s): Yukiko Kato
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse, Kyoto, Japan
  • Year and Date: 2014-04-14