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Roles of humoral factors and organ-organ or cell-cell communications in the development and progression of metabolic kidney diseases

Research Project

Project/Area Number 26461226
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKumamoto University

Principal Investigator

MUKOYAMA Masashi  熊本大学, 大学院生命科学研究部(医), 教授 (40270558)

Co-Investigator(Renkei-kenkyūsha) MORI Kiyoshi  静岡県立大学, 薬学部, 特任教授 (60343232)
Research Collaborator KUWABARA Takashige  熊本大学, 大学院生命科学研究部, 助教 (00393356)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腎臓学 / 内分泌学 / メタボリック症候群 / 糖尿病性腎症 / レニン・アンジオテンシン系 / ナトリウム利尿ペプチド / N型カルシウムチャネル / 自然炎症 / 高血圧 / アルドステロン / マクロファージ / metabolic syndrome / 肥満症 / renin-angiotensin system
Outline of Final Research Achievements

Lifestyle-related noncommunicable diseases such as diabetes, obesity and hypertension are the major risk for metabolic kidney diseases, in which endocrine dysregulation in organ-organ or cell-cell communications in the kidney may be suggested. We investigated roles of humoral factors in this pathophysiology.
We found that the natriuretic peptide (ANP and BNP) receptor GC-A in podocytes is important in protecting against aldosterone-induced glomerular injury in mice. We also found the role of N-type calcium channels in sympathetic nerve activation and podocyte injury in obese diabetic mice with nephropathy. Finally, we found the pathogenic role of local homeostatic inflammation driven by toll-like receptor 4 and its endogenous ligand myeloid-related protein 8 (MRP8), a macrophage-derived proinflammatory factor, in mouse models of diabetes-hyperlipidemia as well as proliferative nephritis. These findings may provide potential therapeutic strategies for metabolic kidney diseases.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (58 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (20 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 20 results,  Open Access: 12 results,  Acknowledgement Compliant: 16 results) Presentation (35 results) (of which Int'l Joint Research: 23 results,  Invited: 6 results)

  • [Int'l Joint Research] University of Bristol(United Kingdom)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Bristol(United Kingdom)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] National Heart, Lung and Blood Institute(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Production and analysis of conditional KO mice of CCN2 in kidney.2017

    • Author(s)
      N. Toda, H. Yokoi, K. Mori, M. Mukoyama
    • Journal Title

      Methods in Molecular Biology

      Volume: 1489 Pages: 377-390

    • DOI

      10.1007/978-1-4939-6430-7_31

    • ISBN
      9781493964284, 9781493964307
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Analysis of pathological activities of CCN proteins in fibrotic diseases: Kidney fibrosis.2017

    • Author(s)
      H. Yokoi, M. Mukoyama
    • Journal Title

      Methods in Molecular Biology

      Volume: 1489 Pages: 431-443

    • DOI

      10.1007/978-1-4939-6430-7_36

    • ISBN
      9781493964284, 9781493964307
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.2017

    • Author(s)
      Mori KP, Yokoi H, Kasahara M, Imamaki H, Ishii A, Kuwabara T, Koga K, Kato Y, Toda N, Ohno S, Kuwahara K, Endo T, Nakao K, Yanagita M, Mukoyama M, Mori K.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 28 Issue: 1 Pages: 278-289

    • DOI

      10.1681/asn.2015101168

    • NAID

      120005820888

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crucial role of mesangial cell-derived connective tissue growth factor in a mouse model of anti-glomerular basement membrane glomerulonephritis.2017

    • Author(s)
      Toda N, Mori K, Kasahara M, Ishii A, Koga K, Ohno S, Mori KP. Kato Y, Osaki K, Kuwabara T, Kojima K, Taura D, Sone M, Matsusaka T, Nakao K, Mukoyama M, Yanagita M, Yokoi H.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 42114-42114

    • DOI

      10.1038/srep42114

    • NAID

      120005997757

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition.2017

    • Author(s)
      Y. Kato, K. Mori, M. Kasahara, K. Osaki, A. Ishii, K.P. Mori, N. Toda, S. Ohno, T. Kuwabara, T. Tokudome, I. Kishimoto, M.A. Saleem, T. Matsusaka, K. Nakao, M. Mukoyama, M. Yanagita, H. Yokoi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 46624-46624

    • DOI

      10.1038/srep46624

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.2017

    • Author(s)
      Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 未定 Issue: 9 Pages: 000-000

    • DOI

      10.1093/ndt/gfw463

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.2016

    • Author(s)
      Ohno S, Yokoi H, Mori K, Kasahara M, Kuwahara K, Fujikura J, Naito M, Kuwabara T, Imamaki H, Ishii A, Saleem MA, Numata T, Mori Y, Nakao K, Yanagita M, Mukoyama M
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 27192-27192

    • DOI

      10.1038/srep27192

    • NAID

      120007100128

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Human induced pluripotent stem cell-derived podocytes mature into vascularized glomeruli upon experimental transplantation.2016

    • Author(s)
      Sharmin S, Taguchi A, Kaku Y, Yoshimura Y, Ohmori T, Sakuma T, Mukoyama M, Yamamoto T, Kurihara H, Nishinakamura R
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Issue: 6 Pages: 1778-1791

    • DOI

      10.1681/asn.2015010096

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mild systemic thermal therapy ameliorates renal dysfunction in a rodent model of chronic kidney disease.2016

    • Author(s)
      Iwashita Y, Kuwabara T, Hayata M, Kakizoe Y, Izumi Y, Iiyama J, Kitamura K, Mukoyama M.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: in press Issue: 11 Pages: 1-1

    • DOI

      10.1152/ajprenal.00519.2015

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity.2016

    • Author(s)
      Y. Kakizoe, Y. Miyasato, T. Onoue, T. Nakagawa, M. Hayata, K. Uchimura, J. Morinaga, T. Mizumoto, M. Adachi, T. Miyoshi, Y. Sakai, K. Tomita, M. Mukoyama, K. Kitamura
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 132 Issue: 2 Pages: 145-153

    • DOI

      10.1016/j.jphs.2016.09.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Angiopoietin-like protein 2 increases renal fibrosis by accelerating transforming growth factor-β signaling in chronic kidney disease.2016

    • Author(s)
      Jun Morinaga, Tsuyoshi Kadomatsu, Keishi Miyata, Motoyoshi Endo, Kazutoyo Terada, Zhe Tian, Taichi Sugizaki, Hiroki Tanigawa, Jiabin Zhao, Shunshun Zhu, Michio Sato, Kimi Araki, Ken-ichi Iyama, Kengo Tomita, Masashi Mukoyama, Kimio Tomita, Kenichiro Kitamura, Yuichi Oike
    • Journal Title

      Kidney International

      Volume: 89 Issue: 2 Pages: 327-341

    • DOI

      10.1016/j.kint.2015.12.021

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.2016

    • Author(s)
      Yuki Narita, Miki Ueda, Kohei Uchimura, Yutaka Kakizoe, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Terumasa Nakagawa, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Daisuke Kadowaki, Sumio Hirata, Masashi Mukoyama, Kenichiro Kitamura
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 130 Issue: 2 Pages: 110-116

    • DOI

      10.1016/j.jphs.2016.01.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peptide affinity analysis of proteins that bind to an unstructured NH2-terminal region of the osmoprotective transcription factor NFAT5.2016

    • Author(s)
      Jenna F. DuMond, Kevin Ramkissoon, Xue Zhang, Yuichiro Izumi, Xujing Wang, Koji Eguchi, Shouguo Gao, Masashi Mukoyama, Maurice B. Burg, Joan D. Ferraris
    • Journal Title

      Physiological Genomics

      Volume: 48 Issue: 4 Pages: 290-305

    • DOI

      10.1152/physiolgenomics.00110.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MicroRNA-26a inhibits TGF-β-induced extracellular matrix expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy.2015

    • Author(s)
      Koga K, Yokoi H, Mori K, Kasahara K, Kuwabara T, Imamaki H, Ishii A, Mori KP, Kato Y, Ohno S, Toda N, Saleem MA, Sugawara A, Nakao K, Yanagita M, Mukoyama M.
    • Journal Title

      Diabetologia

      Volume: 58 Issue: 9 Pages: 2169-80

    • DOI

      10.1007/s00125-015-3642-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients.2015

    • Author(s)
      Imamaki H, Ishii A, Yokoi H, Kasahara M, Kuwabara T, Mori KP, Kato Y, Kuwahara T, Satoh M, Nakatani K, Saito Y, Tomosugi N, Sugawara A, Nakao K, Mukoyama M, Yanagita M, Mori K.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: 99-106

    • DOI

      10.1371/journal.pone.0132539

    • NAID

      120005678176

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reduction of Tubular Flow Rate as a Mechanism of Oliguria in the Early Phase of Endotoxemia Revealed by Intravital Imaging.2015

    • Author(s)
      Nakano D, Doi K, Kitamura H, Kuwabara T, Mori K, Mukoyama M, Nishiyama A.
    • Journal Title

      J Am Soc Nephrol

      Volume: 26 Issue: 12 Pages: 3035-44

    • DOI

      10.1681/asn.2014060577

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An AKI biomarker lipocalin 2 in the blood derives from the kidney in renal injury but from neutrophils in normal and infected conditions.2015

    • Author(s)
      Kanda J, Mori K, Kawabata H, Kuwabara T, Mori KP, Imamaki H, Kasahara M, Yokoi H, Mizumoto C, Thoennissen NH, Koeffler HP, Barasch J, Takaori-Kondo A, Mukoyama M, Nakao K.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 19 Issue: 1 Pages: 99-106

    • DOI

      10.1007/s10157-014-0952-7

    • NAID

      120005678175

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects.2015

    • Author(s)
      Miki Ueda, Kohei Uchimura, Yuki Narita, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Yutaka Kakizoe, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Daisuke Kadowaki, Y Sakai, Masashi Mukoyama, Kenichiro Kitamura
    • Journal Title

      Nephron

      Volume: 129 Issue: 3 Pages: 223-232

    • DOI

      10.1159/000375308

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Macrophage-mediated glucolipotoxicity via myeloid-related protein 8/toll-like receptor 4 signaling in diabetic nephropathy2014

    • Author(s)
      Kuwabara, T., Mori, K., Mukoyama, M., Kasahara, M., Yokoi, H., Nakao, K.
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: impress Issue: 4 Pages: 584-592

    • DOI

      10.1007/s10157-013-0922-5

    • NAID

      120005474441

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of erythropoietin production by the nephron2014

    • Author(s)
      Nagai T, Yasuoka Y, Kawahara K, Nonoguchi H, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 449 Issue: 3 Pages: 222-228

    • DOI

      10.1016/j.bbrc.2014.09.089

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Matrix metalloproteinase-10 in glomeruli of aldosterone-infused systemic and podocyte-specific guanylyl cyclase-A knockout mice.2016

    • Author(s)
      Keisuke Osaki
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Deletion of sirtuin 7 ameliorates cisplatin-induced acute kidney injury through regulation of inflammatory response.2016

    • Author(s)
      Yoshikazu Miyasato
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intraglomerular crosstalk between mesangial cells and macrophages in glomerular injury.2016

    • Author(s)
      Shuro Umemoto
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Myeloid-specific deletion of MRP8 ameliorates glomerulonephritis through affecting macrophage characterization.2016

    • Author(s)
      Takashige Kuwabara
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In silico and in vitro characterization of low pH-induced genes in intercalated cells of the collecting ducts.2016

    • Author(s)
      Yuichiro Izumi
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of aldosterone and the ubiquitin-proteasome system in the regulation of expression of an ammonia transporter, rhesus blood group C glycoprotein, in the intercalated cells.2016

    • Author(s)
      Koji Eguchi
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A serine protease inhibitor increases osmotic free water excretion together with suppressed urinary exosomal AQP2 excretion.2016

    • Author(s)
      Yutaka Kakizoe
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Doxycycline ameliorates cisplatin-induced nephrotoxicity in mice through directly acting on proximal tubular cells and promoting cell viability.2016

    • Author(s)
      Terumasa Nakagawa
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 降圧治療から臓器保護を目指した治療へ:新たな降圧薬としてのARNiの可能性2016

    • Author(s)
      向山政志
    • Organizer
      第39回日本高血圧学会総会
    • Place of Presentation
      仙台国際センター, 仙台
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Glomerular MRP8 expression predicts progression of proteinuria in obese or type 2 diabetic patients.2016

    • Author(s)
      Takashige Kuwabara
    • Organizer
      26th Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      COEX, Seoul, Korea
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of activated renin-angiotensin system for the MRP8/TLR4 signaling in diabetic nephropathy.2016

    • Author(s)
      Shuro Umemoto
    • Organizer
      26th Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      COEX, Seoul, Korea
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Computational analysis of the effects of aldosterone and metabolic acidosis on gene expressions in renal tubules.2016

    • Author(s)
      Yuichiro Izumi
    • Organizer
      26th Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      COEX, Seoul, Korea
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aldosterone modulates expression of an acid-secreting ammonia transporter Rhcg in intercalated cells of the collecting ducts.2016

    • Author(s)
      Koji Eguchi
    • Organizer
      26th Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      COEX, Seoul, Korea
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A serine protease inhibitor increases osmotic free water excretion in normal rats.2016

    • Author(s)
      Yutaka Kakizoe
    • Organizer
      26th Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      COEX, Seoul, Korea
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serine protease inhibition attenuates salt-sensitive hypertension and podocyte injury in a rat model of metabolic syndrome.2016

    • Author(s)
      Yutaka Kakizoe
    • Organizer
      26th Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      COEX, Seoul, Korea
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of the renin-angiotensin system in diabetic nephropathy induces local inflammation through intraglomerular crosstalk.2016

    • Author(s)
      Takashige Kuwabara
    • Organizer
      15th Asian Pacific Congress of Nephrolgy
    • Place of Presentation
      Perth Convention and Exhibition Centre, Perth, Australia
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microalbuminuric stage of diabetic nephropathy is characterized with enhancement of total nephron albumin filtration and reabsorption.2016

    • Author(s)
      Keita P. Mori
    • Organizer
      15th Asian Pacific Congress of Nephrolgy
    • Place of Presentation
      Perth Convention and Exhibition Centre, Perth, Australia
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新たな降圧薬としてのangiotensin receptor-neprilysin inhibitor (ARNi)2016

    • Author(s)
      向山政志
    • Organizer
      第5回臨床高血圧フォーラム
    • Place of Presentation
      ステーションコンファレンス東京, 東京
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Role of the N-type calcium channel in a mouse model of diabetic nephropathy.2015

    • Author(s)
      Shoko Ohno
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel drug-inducible megalin knockout mice reveal marked increase of both total nephron glomerular filtration and tubular reabsorption of albumin in early diabetic nephropathy.2015

    • Author(s)
      Keita P. Mori
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prediction of changes in serum albumin levels among hemodialysis patients by serum neutrophil gelatinase-associated lipocalin levels.2015

    • Author(s)
      Hirotaka Imamaki
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The protective role of doxycycline for cisplatin-induced AKI by its anti-inflammatory and anti-oxidative effects.2015

    • Author(s)
      Terumasa Nakagawa
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] HIF1a and HIGF2-induced erythropoietin production along the nephron.2015

    • Author(s)
      Yuichiro Izumi
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] TSS-Seq analysis of low pH-induced gene transcripts in the intercalated cells of the collecting ducts.2015

    • Author(s)
      Yuichiro Izumi
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Regulation of Rhcg by aldosterone in intercalated cells of the collecting ducts.2015

    • Author(s)
      Koji Eguchi
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Na調節の考え方と循環調節ホルモン2015

    • Author(s)
      向山政志
    • Organizer
      第45回日本腎臓学会西部学術大会
    • Place of Presentation
      金沢歌劇座, 金沢
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 循環調節ホルモンと臓器連関2015

    • Author(s)
      向山政志
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      ひめぎんホール, 松山
    • Year and Date
      2015-10-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 心腎代謝連関と心臓血管ホルモン2015

    • Author(s)
      向山政志
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ東京, 東京
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Kidney myeloid-related protein 8 expression predicts renal prognosis in obese or type 2 diabetic patients.2015

    • Author(s)
      Takashige Kuwabara
    • Organizer
      The World Congress of Nephrology 2015
    • Place of Presentation
      Cape Town International Convention Centre, Cape Town, South Africa
    • Year and Date
      2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Role of the natriuretic peptide GC-A receptor on podocytes in aldosterone-induced glomerular injury.2014

    • Author(s)
      Yukiko Kato
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, USA
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] The role of mesangial cell-derived CTGF in anti-glomerular basement membrane nephritis.2014

    • Author(s)
      Naohiro Toda
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, USA
    • Year and Date
      2014-11-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Glomerular microRNA-26a expression correlates with eGFR in diabetic nephropathy and its regulation in podocytes.2014

    • Author(s)
      Kenichi Koga
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, USA
    • Year and Date
      2014-11-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 高血圧・腎臓病におけるNa利尿ペプチド系と臓器連関2014

    • Author(s)
      向山政志
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2014-10-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Role of N-type calcium channel in diabetic nephropathy.2014

    • Author(s)
      Masashi Mukoyama
    • Organizer
      Joint Meeting of the European Society of Hypertension and the International Society of Hypertension
    • Place of Presentation
      Megaron Athens International Conference Centre, Athens, Greece
    • Year and Date
      2014-06-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Inhibition of p38 MAP kinase ameliorates aldosterone-induced podocyte injury in natriuretic peptide receptor (GC-A)-deficient mice.2014

    • Author(s)
      Yukiko Kato
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      Miyakomesse, Kyoto, Japan
    • Year and Date
      2014-04-14
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-01-27  

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