Renoprotecion of acetazolamide and canagliflozin

• Project/Area Number: 26461233
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: NAKAYAMA YUSHI 熊本大学, 医学部附属病院, 講師 (00363531)
• Co-Investigator(Kenkyū-buntansha): 北村 健一郎 山梨大学, 総合研究部, 教授 (10304990) ; 向山 政志 熊本大学, 大学院生命科学研究部(医), 教授 (40270558)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: acetazolamide / diabetic nephropathy / 糖尿病性腎症 / アセタゾラミド / TGF / カナグリフロジン

Outline of Final Research Achievements

In KK-Ay/TaJcl mouse, diabetes mellitus was developed significantly. Creatinine clearance and urinary protein excretion were also increased in KK-Ay/TaJcl mouse compared to control mouse (BALB/cAJcl).
Administration of acetazolamide in food admixture reduced the urinary protein excretion. Increased renin activity observed in DM mouse was reduced by acetazolamid. Creatinine clearance was also decreased in DM mouse. These results indicated the renoprotective action of acetazolamid via tubuloglomerular feedback in diabetic nephropathy.

Research Products

• [Journal Article] Renal tubular acidosis complicated with hyponatremia due to cortisol insufficiency. (2015)
  • Author(s): Izumi Y, Nakayama Y, Onoue T, Inoue H, Mukoyama M.
  • Journal Title: Oxf Med Case Reports. Volume: (11) Issue: 11 Pages: 360-363
  • DOI: 10.1093/omcr/omv063
  • Peer Reviewed / Open Access
• [Journal Article] Renal Angioplasty for Atherosclerotic Renal Artery Stenosis Revisited (2015)
  • Author(s): Mukoyama M, Nakayama Y, Adachi M
  • Journal Title: Circulation Journal Volume: 79 Issue: 2 Pages: 295-296
  • DOI: 10.1253/circj.CJ-14-1361
  • NAID: 130004927050
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Expression of three isoforms of Na-K-2Cl cotransporter (NKCC2) in the kidney and regulation by dehydration.. (2014)
  • Author(s): Itoh K, Izumi Y, Kawahara K, Nonoguchi H, et al.
  • Journal Title: Biochem Biophys Res Commun. Volume: 453 Issue: 2 Pages: 356-361
  • DOI: 10.1016/j.bbrc.2014.05.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reevaluation of erythropoietin production by the nephron (2014)
  • Author(s): Nagai T, Yasuoka Y, Kawahara K, Nonoguchi H, et al.
  • Journal Title: Biochem Biophys Res Commun. Volume: 449 Issue: 3 Pages: 222-228
  • DOI: 10.1016/j.bbrc.2014.09.089
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Low-density lipoprotein apheresis for proteinuria in lupus nephritis with intraglomerular foam cells containing cholesterol crystals. (2014)
  • Author(s): Shiraishi N, Kitamura K, Hayata M, Ogata T, Tajiri-Okamura K, Nakayama Y, Kohda Y, Tomita K, Mukoyama M.
  • Journal Title: Am J Kidney Dis. Volume: 65 Issue: 3 Pages: 490-493
  • DOI: 10.1053/j.ajkd.2014.09.028
  • Peer Reviewed
• [Presentation] New index adjusted U-Pro1.0 is useful to estimate urinary protein (2014)
  • Author(s): 中山裕史
  • Organizer: 米国腎臓学会
  • Place of Presentation: 米国フィラデルフィア
  • Year and Date: 2014-11-15