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Renoprotecion of acetazolamide and canagliflozin

Research Project

Project/Area Number 26461233
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKumamoto University

Principal Investigator

NAKAYAMA YUSHI  熊本大学, 医学部附属病院, 講師 (00363531)

Co-Investigator(Kenkyū-buntansha) 北村 健一郎  山梨大学, 総合研究部, 教授 (10304990)
向山 政志  熊本大学, 大学院生命科学研究部(医), 教授 (40270558)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsacetazolamide / diabetic nephropathy / 糖尿病性腎症 / アセタゾラミド / TGF / カナグリフロジン
Outline of Final Research Achievements

In KK-Ay/TaJcl mouse, diabetes mellitus was developed significantly. Creatinine clearance and urinary protein excretion were also increased in KK-Ay/TaJcl mouse compared to control mouse (BALB/cAJcl).
Administration of acetazolamide in food admixture reduced the urinary protein excretion. Increased renin activity observed in DM mouse was reduced by acetazolamid. Creatinine clearance was also decreased in DM mouse. These results indicated the renoprotective action of acetazolamid via tubuloglomerular feedback in diabetic nephropathy.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (1 results)

  • [Journal Article] Renal tubular acidosis complicated with hyponatremia due to cortisol insufficiency.2015

    • Author(s)
      Izumi Y, Nakayama Y, Onoue T, Inoue H, Mukoyama M.
    • Journal Title

      Oxf Med Case Reports.

      Volume: (11) Issue: 11 Pages: 360-363

    • DOI

      10.1093/omcr/omv063

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal Angioplasty for Atherosclerotic Renal Artery Stenosis Revisited2015

    • Author(s)
      Mukoyama M, Nakayama Y, Adachi M
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 2 Pages: 295-296

    • DOI

      10.1253/circj.CJ-14-1361

    • NAID

      130004927050

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of three isoforms of Na-K-2Cl cotransporter (NKCC2) in the kidney and regulation by dehydration..2014

    • Author(s)
      Itoh K, Izumi Y, Kawahara K, Nonoguchi H, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 453 Issue: 2 Pages: 356-361

    • DOI

      10.1016/j.bbrc.2014.05.014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reevaluation of erythropoietin production by the nephron2014

    • Author(s)
      Nagai T, Yasuoka Y, Kawahara K, Nonoguchi H, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 449 Issue: 3 Pages: 222-228

    • DOI

      10.1016/j.bbrc.2014.09.089

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Low-density lipoprotein apheresis for proteinuria in lupus nephritis with intraglomerular foam cells containing cholesterol crystals.2014

    • Author(s)
      Shiraishi N, Kitamura K, Hayata M, Ogata T, Tajiri-Okamura K, Nakayama Y, Kohda Y, Tomita K, Mukoyama M.
    • Journal Title

      Am J Kidney Dis.

      Volume: 65 Issue: 3 Pages: 490-493

    • DOI

      10.1053/j.ajkd.2014.09.028

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] New index adjusted U-Pro1.0 is useful to estimate urinary protein2014

    • Author(s)
      中山裕史
    • Organizer
      米国腎臓学会
    • Place of Presentation
      米国フィラデルフィア
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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