Renoprotecion of acetazolamide and canagliflozin
| Project/Area Number |
26461233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
NAKAYAMA YUSHI 熊本大学, 医学部附属病院, 講師 (00363531)
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| Co-Investigator(Kenkyū-buntansha) |
北村 健一郎 山梨大学, 総合研究部, 教授 (10304990)
向山 政志 熊本大学, 大学院生命科学研究部(医), 教授 (40270558)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | acetazolamide / diabetic nephropathy / 糖尿病性腎症 / アセタゾラミド / TGF / カナグリフロジン |
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| Outline of Final Research Achievements |
In KK-Ay/TaJcl mouse, diabetes mellitus was developed significantly. Creatinine clearance and urinary protein excretion were also increased in KK-Ay/TaJcl mouse compared to control mouse (BALB/cAJcl).
Administration of acetazolamide in food admixture reduced the urinary protein excretion. Increased renin activity observed in DM mouse was reduced by acetazolamid. Creatinine clearance was also decreased in DM mouse. These results indicated the renoprotective action of acetazolamid via tubuloglomerular feedback in diabetic nephropathy.
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Report
(4 results)
Research Products
(6 results)
