| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we evaluated the role of a serine protease prostasin in the pathogenesis of chronic kidney injury, particularly renal interstitial fibrosis, using renal tubule specific prostasin and its endogenous inhibitor, HAI-1, knock out mice. No amelioration or exaggeration of renal injury was observed in aldosterone/salt model and unilateral ureter obstruction model. Furthermore, the deletion of HAI-1 had no effect on the renal tubule necrosis caused by cisplatin. Our study suggests that renal tubular prostasin and HAI-1 are not associated with renal injury in those disease model.
|
