The evaluation of role of prostasin in the proximal tubule with Pax8-rtTA/LC-1 system.
Project/Area Number |
26461234
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Kumamoto University |
Principal Investigator |
Kakizoe Yutaka 熊本大学, 大学院生命科学研究部(医), 助教 (70583037)
|
Co-Investigator(Kenkyū-buntansha) |
北村 健一郎 山梨大学, 大学院総合研究部, 教授 (10304990)
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Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | プロスタシン / HAI-1 / セリンプロテアーゼ / 慢性腎臓病 / アルドステロン / HAI-Ⅰ / 急性腎障害 / 食塩 / 腎線維化 |
Outline of Final Research Achievements |
In this study, we evaluated the role of a serine protease prostasin in the pathogenesis of chronic kidney injury, particularly renal interstitial fibrosis, using renal tubule specific prostasin and its endogenous inhibitor, HAI-1, knock out mice. No amelioration or exaggeration of renal injury was observed in aldosterone/salt model and unilateral ureter obstruction model. Furthermore, the deletion of HAI-1 had no effect on the renal tubule necrosis caused by cisplatin. Our study suggests that renal tubular prostasin and HAI-1 are not associated with renal injury in those disease model.
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Report
(5 results)
Research Products
(9 results)
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[Journal Article] Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.2016
Author(s)
Yuki Narita, Miki Ueda, Kohei Uchimura, Yutaka Kakizoe, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Terumasa Nakagawa, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Daisuke Kadowaki, Sumio Hirata, Masashi Mukoyama, Kenichiro Kitamura
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Journal Title
Journal of Pharmacological Sciences
Volume: 130
Issue: 2
Pages: 110-116
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects.2015
Author(s)
Miki Ueda, Kohei Uchimura, Yuki Narita, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Yutaka Kakizoe, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Daisuke Kadowaki, Y Sakai, Masashi Mukoyama, Kenichiro Kitamura
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Journal Title
Nephron
Volume: 129
Issue: 3
Pages: 223-232
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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