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Mechanisms to develop renal cyst formation and progression by disruption of cilia/centriole and cell cycle relationships

Research Project

Project/Area Number 26461235
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

yokoyama Takahiko  京都府立医科大学, 医学(系)研究科(研究院), 教授 (70191525)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腎嚢胞 / 細胞増殖 / 細胞周期 / 繊毛 / 腎臓 / 嚢胞腎 / アポトーシス / 嚢胞 / Fucci / inv
Outline of Final Research Achievements

Renal cysts occur when kidney tubules become enlarged. These cysts are observed in numerous genetic deceases and, recently, several causative genes for these deceases have been cloned. Most of the products of these genes are localized in cilia and/or centrioles. In addition, mutant mice lacking cilia develop renal cysts. Therefore, cilia are thought to have an important role in renal cystogenesis.
Ne of the mechanisms to develop renal cysts is abnormal cell proliferation. Presence of cilium is tightly linked with cell cycle. In the present study, we studied relationships among cell cycle, cell proliferation and renal cyst development in detail.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] Ciliary subcompartments and cysto-proteins.2017

    • Author(s)
      Yokoyama T
    • Journal Title

      Anat Sci Int.

      Volume: 92 Issue: 2 Pages: 207-214

    • DOI

      10.1007/s12565-015-0302-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis of the Inv compartment and ciliary abnormalities in Inv/nphp2 mutant mice.2016

    • Author(s)
      Tsuji T, Matsuo K, Nakahari T, Marunaka Y, Yokoyama T.
    • Journal Title

      Structural basis of the Inv compartment and ciliary abnormalities in Inv/nphp2 mutant mice.

      Volume: 73 Issue: 1 Pages: 45-56

    • DOI

      10.1002/cm.21264

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 嚢胞性腎疾患と繊毛2014

    • Author(s)
      横山尚彦
    • Journal Title

      腎と透析

      Volume: 77 Pages: 705-710

    • Related Report
      2014 Research-status Report
  • [Presentation] Inv compartment lnephrocystins2017

    • Author(s)
      T Yokoyama
    • Organizer
      The Kitasato-Yale Fluid Symposium 2017: Molecular Control of Cellular and Epithelial Function
    • Place of Presentation
      Shirakane, Tokyo
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 尿細管形成と嚢胞発生機構2016

    • Author(s)
      横山尚彦
    • Organizer
      『上皮膜輸送調節蛋白の異常と 病態生理学の融合』
    • Place of Presentation
      自然科学研究機構 生理学研究所
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 若年性ネフロン癆(NPHP)原因遺伝子Inv/Nphp2の 網膜およひ;気管上 皮における機能解析2016

    • Author(s)
      松尾和彦、中張隆司、丸中良典、横山
    • Organizer
      第121回日本解剖学会
    • Place of Presentation
      福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 一次繊毛に局在するNephrocystin-3の機能解析2016

    • Author(s)
      中島由朗、陳琳、横山尚彦
    • Organizer
      第121回日本解剖学会
    • Place of Presentation
      福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Analysis of the medaka intestinal atresia mutant2016

    • Author(s)
      Kobayashi D and Yokoyama T
    • Organizer
      第121回日本解剖学会
    • Place of Presentation
      福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Cilia localization signal of nephrocystin-3 is crucial for the kidney morphogenesis, but not situs determination.2015

    • Author(s)
      Nakajima Y and Yokoyama T
    • Organizer
      FASEB meeting
    • Place of Presentation
      Snowmass, Corolado
    • Year and Date
      2015-07-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Structural base of the Inv compartment and ciliary abnormality in the inv mutant mice2015

    • Author(s)
      Matsuo K, Tuji T and Yokoyama T
    • Organizer
      FASEB meeting
    • Place of Presentation
      Snowmass, Corolado
    • Year and Date
      2015-07-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ciliary subdomains and abnormality in the kidney of inv mutant mice2015

    • Author(s)
      横山尚彦、辻琢磨
    • Organizer
      第120回解剖学会総会第92回生理学会合同大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Roles of a ciliary gene, Nphp2/inv in cell cycle control2015

    • Author(s)
      茂田昌樹、中島由郎、横山尚彦
    • Organizer
      第120回解剖学会総会第92回生理学会合同大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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