| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Renal cysts occur when kidney tubules become enlarged. These cysts are observed in numerous genetic deceases and, recently, several causative genes for these deceases have been cloned. Most of the products of these genes are localized in cilia and/or centrioles. In addition, mutant mice lacking cilia develop renal cysts. Therefore, cilia are thought to have an important role in renal cystogenesis.
Ne of the mechanisms to develop renal cysts is abnormal cell proliferation. Presence of cilium is tightly linked with cell cycle. In the present study, we studied relationships among cell cycle, cell proliferation and renal cyst development in detail.
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