Mechanisms to develop renal cyst formation and progression by disruption of cilia/centriole and cell cycle relationships
| Project/Area Number |
26461235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
yokoyama Takahiko 京都府立医科大学, 医学(系)研究科(研究院), 教授 (70191525)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腎嚢胞 / 細胞増殖 / 細胞周期 / 繊毛 / 腎臓 / 嚢胞腎 / アポトーシス / 嚢胞 / Fucci / inv |
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| Outline of Final Research Achievements |
Renal cysts occur when kidney tubules become enlarged. These cysts are observed in numerous genetic deceases and, recently, several causative genes for these deceases have been cloned. Most of the products of these genes are localized in cilia and/or centrioles. In addition, mutant mice lacking cilia develop renal cysts. Therefore, cilia are thought to have an important role in renal cystogenesis.
Ne of the mechanisms to develop renal cysts is abnormal cell proliferation. Presence of cilium is tightly linked with cell cycle. In the present study, we studied relationships among cell cycle, cell proliferation and renal cyst development in detail.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] 尿細管形成と嚢胞発生機構2016
Author(s)
横山尚彦
Organizer
『上皮膜輸送調節蛋白の異常と 病態生理学の融合』
Place of Presentation
自然科学研究機構 生理学研究所
Year and Date
2016-11-24
Related Report
Invited
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