Does the reverse transcriptase inhibitor, Efavirenz, have a therapeutic effect for crescentic nephritis?
| Project/Area Number |
26461238
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
Yoshio Shimizu 順天堂大学, 医学部, 先任准教授 (50359577)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 半月体形成性腎炎 / レトロトランスポゾン / 実験腎炎 / 逆転写酵素 / 糸球体腎炎 / 半月体 / 逆転写酵素阻害薬 |
|---|
| Outline of Final Research Achievements |
We reported that retrotransposon activated a glomerular crescent forming phase in mouse BSA nephritis and a reverse transcriptase inhibitor, Efavirenz, clearly prevented crescent formation. We tried the same protocol to the hL1-EGFP Tg mice which over-express human retrotransposon and show the retrotransposition site by EGFP. By Immunofluorescence, EGFP was not detected in the BSA nephritis tissues. It was suggested that abundant small DNA driven by L1 retrotransposon is a possible inducer of crescent formation.
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Report
(5 results)
Research Products
(31 results)
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[Journal Article] B-type (brain) natriuretic peptide and pruritus in hemodialysis patients.2014
Author(s)
Shimizu Y, Sonoda A, Nogi C, Ogushi Y, Kanda R, Yamaguchi S, Nohara N, Aoki T, Yamada K, Nakata J, Io H, Kurusu A, Hamada C, Horikoshi S, Tomino Y.
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Journal Title
Int J Nephrol Renovasc Dis.
Volume: 25;7
Pages: 329-35
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.2014
Author(s)
Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K, Shibuya A, Tomino Y.
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Journal Title
BMC Nephrology
Volume: 15:89
Issue: 1
Pages: 89-89
DOI
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Peer Reviewed / Open Access
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[Presentation] Serum brain natriuretic peptide (BNP) is a possible enhancer of pruritus of hemodialysis patients2014
Author(s)
Yoshio Shimizu, Ayano Sonoda, Chieko Nogi, Yoko Ogushi, Reo Kanda, Saori Yamaguchi, Nao Nohara, Tatsuya Aoki, Kaori Yamada, Junichiro Nakata, Hiroaki Io, Atsushi Kurusu, Chieko Hamada, Satoshi Horikoshi and Yasuhiko Tomino
Organizer
Asian Pacific Congress of Nephrology 2014
Place of Presentation
品川プリンスホテル
Year and Date
2014-05-16
Related Report
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[Book] 内科外来診断navi2017
Author(s)
富野 康日己、長谷部 直幸、高橋 和久
Total Pages
358
Publisher
中外医学社
ISBN
9784498020740
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