• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clarification of the disease susceptibility gene in IgA nephrology prone mice

Research Project

Project/Area Number 26461240
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionJuntendo University

Principal Investigator

Horikoshi Satoshi  順天堂大学, 医学部, 先任准教授 (80260884)

Co-Investigator(Kenkyū-buntansha) 富野 康日己  順天堂大学, 医学部, 名誉教授 (60130077)
鈴木 祐介  順天堂大学, 医学(系)研究科(研究院), 教授 (70372935)
Research Collaborator MAIGUMA Masayuki  
TAKAHATA Akiko  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsIgA腎症 / gddYマウス / HIGAマウス / 糖鎖修飾 / 次世代シーケンス
Outline of Final Research Achievements

Pathogenesis of IgA nephrology is still unknown. There are some reports which suggest that genetic factors are related to the mutation in genetic region for IgA glucosylation. In this study, we assessed the genetic regions of IgA glucose deficiency by comparing the two mice strains originated from ddY mouse, grouped ddY (gddY) mouse and HIGA mouse. While gddY mouse has early onset of IgAN within a 100% incidence, HIGA
mouse has high serum level of IgA but does not always develop IgAN. By studying the genes using the micro-satellite markers, we found out that genetic area around D12Mit20 may be the responsible gene of glucose deficiency in IgAN. Since we need to consider other methods to compare the other genetic regions as also in full detail, we will introduce the next-genetic sequence method and continue the study.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (26 results)

All 2016 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 9 results,  Open Access: 6 results) Presentation (15 results) Book (1 results)

  • [Journal Article] Predictive factors associated with increased progression to dialysis in early chronic kidney disease (stage 1-3) patients.2016

    • Author(s)
      Nohara N, Io H, Matsumoto M,Furukawa M,Okumura K, Nakata J, Shimizu Y, Horikoshi S, Tomino Y.
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: ahead of print

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeted IgA Fc Receptor I (FcaRI) Therapy in the Early Intervention and Treatment of Pristane Induced Lupus Nephritis in Mice2015

    • Author(s)
      Liu C, Kanamaru Y, Watanabe T, Tada N, Horikoshi S, Suzuki Y, Zhihong L, Tomino Y.
    • Journal Title

      Clin Exp Immunol

      Volume: 181 Issue: 3 Pages: 407-416

    • DOI

      10.1111/cei.12647

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of anaemia treatment for left ventricular remodelling prior to initiation of dialysis in chronic kidney disease patients: Efficacy and stability of long acting erythropoietin stimulating agents.2015

    • Author(s)
      Io H, Aizawa M, Funabiki K, Horikoshi S, Tomino Y.
    • Journal Title

      Nephrology (Carlton).

      Volume: 20 Suppl 4 Issue: S4 Pages: 7-13

    • DOI

      10.1111/nep.12640

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] EBV関連T/NK細胞リンパ増殖疾患の経過中に腎障害をきたした2症例(原著論文)2015

    • Author(s)
      久田 温子, 大澤 勲, 増田 敦美, 河本 敏雄, 天野 浩文, 浜埜 康晴, 堀越 哲, 小松 則夫, 高崎 芳成, 富野 康日己
    • Journal Title

      腎と透析

      Volume: 78巻4号

    • Related Report
      2015 Research-status Report
  • [Journal Article] The kinetics of glomerular deposition of nephritogenic IgA2014

    • Author(s)
      Yamaji K, Suzuki Y, Suzuki H, Satake K, Horikoshi S, Novak J, Tomino Y
    • Journal Title

      PLoS One

      Volume: 9 Issue: 11 Pages: e113005-e113005

    • DOI

      10.1371/journal.pone.0113005

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.2014

    • Author(s)
      Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K, Shibuya A, Tomino Y.
    • Journal Title

      BMC Nephrology

      Volume: 15:89 Issue: 1 Pages: 89-89

    • DOI

      10.1186/1471-2369-15-89

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy.2014

    • Author(s)
      Aizawa M, Suzuki Y, Suzuki H, Pang H, Kihara M, Nakata J, Yamaji K, Horikoshi S, Tomino Y.
    • Journal Title

      PLoS One

      Volume: 17 Issue: 4 Pages: e95365-e95365

    • DOI

      10.1371/journal.pone.0095365

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy in patients with immunoglobulin A nephropathy.2014

    • Author(s)
      Kawamura T, Yoshimura M, Miyazaki Y, Okamoto H, Kimura K, Hirano K, Matsushima M, Utsunomiya Y, Ogura M, Yokoo T, Okonogi H, Ishii T, Hamaguchi A, Ueda H, Furusu A, Horikoshi S, Suzuki Y, Shibata T, Yasuda T, Shirai S, Imasawa T, Kanozawa K, Wada A, Matsuo S, Tomino Y(他6名)
    • Journal Title

      Nephrol Dial Transplant

      Volume: 29(8) Issue: 8 Pages: 1546-53

    • DOI

      10.1093/ndt/gfu020

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in nephritogenic serum galactose-deficient IgA1 in IgA nephropathy following tonsillectomy and steroid therapy.2014

    • Author(s)
      Nakata J, Suzuki Y, Suzuki H, Sato D, Kano T, Yanagawa H, Matsuzaki K, Horikoshi S, Novak J, Tomino Y.
    • Journal Title

      PLoS One.

      Volume: 21;9(2)

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy.2014

    • Author(s)
      Suzuki Y, Matsuzaki K, Suzuki H, Okazaki K, Yanagawa H, Ieiri N, Sato M, Sato T, Taguma Y, Matsuoka J, Horikoshi S, Novak J, Hotta O, Tomino Y.
    • Journal Title

      Clin Exp Nephrol

      Volume: 18 Issue: 5 Pages: 770-777

    • DOI

      10.1007/s10157-013-0921-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Key role of Apoptosis Inhibitor of Macrophage in Phlogogenic Action of Glomerular Nephritogenic IgA in IgA Nephropathy2016

    • Author(s)
      Akiko Takahata, Kento Kitada, Chieko Nogi, Satoko Arai, Yuko Makita, Hitoshi Suzuki, Junichiro Nakata, Satoshi Horikoshi, Toru Miyazaki, Yusuke Suzuki
    • Organizer
      15th APCN Annual Scientific Meeting
    • Place of Presentation
      Perth
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] TLR9活性化のよる糖鎖異常IgAおよび免疫複合体形成機序の解明2016

    • Author(s)
      牧田侑子、鈴木仁、高畑暁子、狩野俊樹、堀越哲、鈴木祐介
    • Organizer
      第59回 日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] AIM/CD5LはIgAの沈着と起炎性を制御する2016

    • Author(s)
      高畑暁子、北田研人、禾千絵子、新井郷子、牧田侑子、鈴木仁、中田純一郎、堀越哲、宮崎徹、鈴木祐介
    • Organizer
      第59回 日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腹膜中皮細胞における抗酸化物質アスタキサンチンの上皮間葉転換抑制に関する検討2016

    • Author(s)
      原一彰、濱田千江子、若林啓一、神田怜生、井尾浩章、金子佳代、堀越哲
    • Organizer
      第59回 日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性間欠的低酸素状況での腎臓を介した酸化ストレス発生機序に関する検討2016

    • Author(s)
      高橋敬子、小林敬、菅谷健、西山成、藤澤良秀、堀越哲、鈴木祐介
    • Organizer
      第59回 日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pathophysiological role of kidney in systemic oxidative stress during chronic intermittent hypoxia.2016

    • Author(s)
      Takahashi K, Kobayashi T, Sugaya T, Nishiyama A, Fujisawa Y, Horikoshi S, Suzuki Y
    • Organizer
      53rd ERA-EDTA
    • Place of Presentation
      Vienna
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] AIM(CD5L) REGULATES GLOMERULAR IGA DEPOSITION AND ITS PHLOGOGENISITY IN IGA NEPHROPATHY2016

    • Author(s)
      Akiko Takahata, Kento Kitada, Chieko Nogi, Satoko Arai, Yuko Makita, Hitoshi Suzuki, Junichiro Nakata, Satoshi Horikoshi, Toru Miyazaki, Yusuke Suzuki
    • Organizer
      53rd ERA-EDTA
    • Place of Presentation
      Vienna
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] TLR9 activation aggravates murine IgA nephropathy; possible role of BAFF mediated pathway.2015

    • Author(s)
      Makita Y, Suzuki H, Takahata A, Kano T, Horikoshi S, Suzuki Y
    • Organizer
      ASN Kidney Week 2015 Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Key role of Apoptosis Inhibitor of Macrophage in Phlogogenic Action of Glomerular Nephritogenic IgA in IgA Nephropathy2015

    • Author(s)
      Akiko Takahata, Kento Kitada, Chieko Nogi, Satoko Arai, Yuko Makita, Hitoshi Suzuki, Junichiro Nakata, Satoshi Horikoshi, Toru Miyazaki, Yusuke Suzuki
    • Organizer
      ASN Kidney Week 2015 Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Severe renal interstitial fibrosis can be a predictor of renal function with lupus nephritis, especially in cases with ISN/RPS class IV2015

    • Author(s)
      Honda D, Onda-Tsueshita K, Ohsawa I, Inoshita H, Horikoshi S, Tomino Y.
    • Organizer
      ASN Kidney Week 2015 Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Significance of total complement hemolytic activity (CH50) fluctuation in nutritional status after the transition from hemodialysis to on-line hemodiafiltration2015

    • Author(s)
      Honda D, Inoshita H, Ohsawa I, Shoji K, Hisada A, Mano S, Nagano M, Tomino Y, Horikoshi S.
    • Organizer
      ISHD
    • Place of Presentation
      Kuala Lumpur
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report
  • [Presentation] The difference of clinical and laboratory characteristics between hereditary angioedema and other types of angioedema2015

    • Author(s)
      Hisada A, Ohsawa I, Sato N, Honda D, Shimamoto M, Nagamach S, Mano S, Horikoshi S, Tomino Y
    • Organizer
      9th C1-inhibitor deficiency workshop
    • Place of Presentation
      Budapest, Hungary.
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
  • [Presentation] Suppressive effect of astaxanthin on epitherial-mesemchimal transition in mesotherial cells isolated from tempareture-sensitive SV40 large T-antigen gene transgenic rats2015

    • Author(s)
      Hara K, Hamada C,Wakabayashi K, Kanda R, Nakano T, Kaneko K, Io H, Horikoshi S, Tomino Y
    • Organizer
      European Society of Nephrology (52thERA/EDTA)
    • Place of Presentation
      London
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
  • [Presentation] IgA腎症におけるTWEAK/Fn14系の関与.2014

    • Author(s)
      佐々木洋平、清水芳男、鈴木祐介、堀越哲、富野康日己.
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Non-IgAメサンギウム増殖性糸球体腎炎の臨床・病理学的検討.2014

    • Author(s)
      久田温子、本田大介、島本真実子、長町誠嗣、井下博之、真野訓、大澤勲、堀越哲、富野康日己.
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Research-status Report
  • [Book] 腎臓病・高血圧と薬剤2014

    • Author(s)
      富野康日己編(分担執筆)
    • Total Pages
      240
    • Publisher
      中外医学社
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi