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Significance of Klotho as a target molecule for CKD progression, severe process and early intervention

Research Project

Project/Area Number 26461243
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionTokyo Women's Medical University

Principal Investigator

TSUCHIYA KEN  東京女子医科大学, 医学部, 教授 (00246472)

Co-Investigator(Kenkyū-buntansha) 土谷 まり子  東京女子医科大学, 医学部, 准教授 (00266826)
浅宮 有香理  東京女子医科大学, 医学部, 助教 (40596566)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords慢性腎臓病 / Klotho / リン / 線維化 / CKD / AKI / klotho / fetuin A / futuin A / Phosphate
Outline of Final Research Achievements

It is estimated that fibrosis in renal tubules / interstitia is important for progression and severity of chronic kidney disease (CKD) irrespective of the causative disease. Conventionally, in renal impairment, a protein restricted diet is indicated, but it is presumed that the phosphorus component of this protein acts in tissue disorder. Klotho protein that regulates this phosphorus was discovered, and the decline in its work further exacerbates renal impairment, suggesting the possibility of being treated in the future.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Fibroblast growth factor 23 and soluble Klotho in patients with autosomal dominant polycystic kidney disease.2016

    • Author(s)
      Akiyama K, Mochizuki T, Kataoka H, Tsuchiya K, Nitta K.
    • Journal Title

      Nephrology

      Volume: - Issue: 11 Pages: 843-858

    • DOI

      10.1111/nep.12862

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New insight into atherosclerosis in hemodialysis patients: overexpression of scavenger receptor and macrophage colony-stimulating factor genes2016

    • Author(s)
      Nishida M, Ando M, Iwamoto Y, Tsuchiya K, Nitta K.
    • Journal Title

      Nephron Extra

      Volume: 6 Pages: 22-30

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FGF23-aKlotho内分泌系と老化2016

    • Author(s)
      杉浦秀和, 土谷 健、黒尾 誠
    • Journal Title

      アンチ・エイジング医学-日本抗加齢医学会雑誌

      Volume: 12 Pages: 30-37

    • Related Report
      2016 Annual Research Report
  • [Journal Article] CKD-MBDにおける骨病変2016

    • Author(s)
      矢島愛治、土谷 健、横田博樹、新田孝作
    • Journal Title

      CLINICAL CALCIUM

      Volume: 26 Pages: 69-74

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Klotho/FGF23 Axis in CKD.2015

    • Author(s)
      Tsuchiya K, Nagano N, Nitta K.
    • Journal Title

      Contrib Nephrol.

      Volume: 185 Pages: 56-65

    • DOI

      10.1159/000380970

    • ISBN
      9783318054644, 9783318054651
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between anaemia management at haemodialysis initiation and patient prognosis.2015

    • Author(s)
      Kataoka H, Tsuchiya K, Naganuma T, Okazaki M, Komatsu M, Kimura T, Shiohira S, Kawaguchi H, Nitta K.
    • Journal Title

      Nephrology (Carlton).

      Volume: 20 Issue: S4 Pages: 14-21

    • DOI

      10.1111/nep.12639

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Klotho/FGF23 Axis in CKD2015

    • Author(s)
      Ken Tsuchiyam Nobuo Naganom Kosaku Nitta
    • Journal Title

      Contrib Nephrol

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] Associations between the levels of sclerostin, phosphate, and fibroblast growth factor-23 and treatment with vitamin D in hemodialysis patients with low intact PTH level.2014

    • Author(s)
      Asamiya Y, Yajima A, Shimizu S, Otsubo S, Tsuchiya K, Nitta K.
    • Journal Title

      Osteoporos Int.

      Volume: 26(3) Issue: 3 Pages: 1017-28

    • DOI

      10.1007/s00198-014-2934-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aortic arch calcification predicts cardiovascular and all-cause mortality in maintenance hemodialysis patients.2014

    • Author(s)
      Komatsu M, Okazaki M, Tsuchiya K, Kawaguchi H, Nitta K.
    • Journal Title

      Kidney Blood Press Res.

      Volume: 39(6) Issue: 6 Pages: 658-67

    • DOI

      10.1159/000368476

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor 23/klotho axis in chronic kidney disease.2014

    • Author(s)
      Nitta K, Nagano N, Tsuchiya K.
    • Journal Title

      Nephron Clin Pract.

      Volume: 128(1-2) Issue: 1-2 Pages: 1-10

    • DOI

      10.1159/000365787

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Repeated minor AKI accelerates renal fibrosis and dysfunction in klotho deficit mice2015

    • Author(s)
      Tsuchiya K, et al.
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      San Diego USA
    • Year and Date
      2015-11-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pre-dialysis to dialysis pathophysiology of Klotho, P, Potassium2014

    • Author(s)
      Ken Tsuchiya
    • Organizer
      The International Society for Hemodialysis
    • Place of Presentation
      上海 中国
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] CKDの病態生理と心腎連関2014

    • Author(s)
      土谷 健
    • Organizer
      第17回生活習慣病を考える会
    • Place of Presentation
      東京 新宿区京王プラザホテル
    • Year and Date
      2014-07-30
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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