| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Analysis of intracellular localization of planar cell polarity factor and cytoskeletal regulator as a candidate factor causing renal tubular expansion in cystic kidneys resulted in no change in localization of the factor. It was inferred that there was no involvement of plane cell polarity and cytoskeleton in renal tubular expansion.
In addition, as a result of development of a method for establishing a renal tubular epithelial cell line from cystic kidney, we succeeded in establishing a cell line from renal tubular epithelial cells before renal tubular expansion in inv_deltaC kidneys.
In addition, point mutant mice were prepared for functional analysis of Inv.
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