Oral Immunological response related to incidence of IgA nephropathy

• Project/Area Number: 26461247
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Hyogo Medical University
• Principal Investigator: Nagasawa Yasuyuki 兵庫医科大学, 医学部, 講師 (10379167)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: IgA腎症 / 歯周病菌 / Treponema denticola / Campylobacter rectus / IFI27 / ＩｇＡ腎症 / 嫌気性菌 / IgA nephropathy / 糸球体腎炎

Outline of Final Research Achievements

Aim is to reveal relationship between immunological response and Treponema denticola or Campylobacter rectus, because we identified these bacteria specific to IgA nephropathy. C57BLmice were treated with these bacteria during 4months, and Campylobacter rectus induced IgA deposition. And We also revealed IFI27 in peripheral white blood cells decreased in IgA nephropathy patients, which was reported as article.

Research Products

• [Journal Article] The association of alcohol and smoking with CKD in a Japanese nationwide cross-sectional survey. (2017)
  • Author(s): Matsumoto A, Nagasawa Y, Yamamoto R, Shinzawa M, Hasuike Y, Kuragano T, Isaka Y, Nakanishi T, Iseki K, Yamagata K, Tsuruya K, Yoshida H, Fujimoto S, Asahi K, Moriyama T, Watanabe T.
  • Journal Title: Hypertens Res Volume: Epub Issue: 8 Pages: 771-778
  • DOI: 10.1038/hr.2017.25
  • Peer Reviewed
• [Journal Article] IFI27 Is a Useful Genetic Marker for Diagnosis of Immunoglobulin A Nephropathy and Membranous Nephropathy Using Peripheral Blood. (2016)
  • Author(s): Nagasawa Y, Okuzaki D, Muso E, Yamamoto R, Shinzawa M, Iwasaki Y, Iwatani H, Nakanishi T, Isaka Y and Nojima H.
  • Journal Title: PLoS One Volume: EPub Issue: 4 Pages: e0153252-e0153252
  • DOI: 10.1371/journal.pone.0153252
  • Peer Reviewed / Open Access
• [Journal Article] Serum Uric Acid Level Predicts Progression of IgA Nephropathy in Females but Not in Males (2016)
  • Author(s): Nagasawa Y, Yamamoto R, Shoji T, Shinzawa M, Hasuike Y, Nagatoya K, Yamauchi A, Hayashi T, Kuragano T, Moriyama T, Isaka Y and Nakanishi T
  • Journal Title: PLoS One Volume: EPub Issue: 8 Pages: e0160828-e0160828
  • DOI: 10.1371/journal.pone.0160828
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of cigarette smoking cessation on CKD: is it a cancer-suppression-like effect or a CVD-suppression-like effect? (2016)
  • Author(s): Nagasawa Y., Kida A,and Nakanisihi T
  • Journal Title: Hypertension Research Volume: Epub Issue: 10 Pages: 690-691
  • DOI: 10.1038/hr.2016.62
  • Peer Reviewed
• [Journal Article] Body Mass Index Modifies an Association between Self-Reported Regular Exercise and Proteinuria (2016)
  • Author(s): Yasuyuki Nagasawa, Ryouhei Yamamoto, Maki Shinzawa, Yukiko Hasuike, Takahiro Kuragano, Yoshitaka Isaka, Takeshi Nakanishi, Kunitoshi Iseki, Kunihiro Yamagata, Kazuhiko Tsuruya, Hideaki Yoshida, Shouichi Fujimoto, Koichi Asahi, Toshiki Moriyama, Tsuyoshi Watanabe
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 4 Pages: 402-412
  • DOI: 10.5551/jat.29009
  • NAID: 130005141426
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Albuminuria and hypertension: the chicken or the egg? (2015)
  • Author(s): Nagasawa Y, Hasuike Y, Nanami M, Kuragano T, Nakanishi T
  • Journal Title: Hypertens Res. Volume: 38 Issue: 1 Pages: 8-10
  • DOI: 10.1038/hr.2014.135
  • Peer Reviewed
• [Journal Article] CD16(+)CD56 (+) cells are a potential culprit for hematuria in IgA nephropathy. (2014)
  • Author(s): Iwatani H, Nagasawa Y, Yamamoto R, Iio K, Mizui M, Horii A, Kitahara T, Inohara H, Kumanogoh A, Imai E, Rakugi H, Isaka Y.
  • Journal Title: Clin Exp Nephrol Volume: 19 Issue: 2 Pages: 216-224
  • DOI: 10.1007/s10157-014-0968-z
  • Peer Reviewed / Open Access
• [Journal Article] An association between serum γ-glutamyltransferase and proteinuria in drinkers and non-drinkers: a Japanese nationwide cross-sectional survey. (2014)
  • Author(s): Ishigami T, Yamamoto R, Nagasawa Y, Isaka Y, Rakugi H, Iseki K, Yamagata K, Tsuruya K, Yoshida H, Fujimoto S, Asahi K, Kurahashi I, Ohashi Y, Moriyama T, Watanabe T.
  • Journal Title: Clin Exp Nephrol. Volume: 18 Issue: 6 Pages: 899-910
  • DOI: 10.1007/s10157-014-0938-5
• [Journal Article] Effect of protoconized therapy for renal anemia on adverse events of patients with maintenance hemodialysis. (2014)
  • Author(s): Kuragano T, Yahiro M, Kida A, Furuta M, Nagasawa Y, Hasuike Y, Nanami M, Nakanishi T.
  • Journal Title: Int J Artif Organs. Volume: 37 Issue: 12 Pages: 865-874
  • DOI: 10.5301/ijao.5000370
• [Journal Article] Serum levels of intact parathyroid hormone is a prognostic indicator of dialyzed patients: the Nishinomiya study. (2014)
  • Author(s): Hasuike Y, Oue M, Hamahata S, Kimura T, Fukao W, Mizusaki K, Kaibe S, Nagasawa Y, Kuragano T, Nakanishi T.
  • Journal Title: Ther Apher Dial. Volume: 18 Issue: 4 Pages: 334-339
  • DOI: 10.1111/1744-9987.12144
• [Presentation] IFI27/ ISG12A in peripheral white blood cells is a useful marker for IgA nephropathy (2016)
  • Author(s): Yasuyuki Nagasawa1, Eri Muso, Ryohei Yamamoto, Maki Shinzawa, Yukako Iwasaki, Hirotsugu Iwatani, Takeshi Nakanishi, Yoshitaka Isaka1
  • Organizer: Annual Meeting of American Society of Nephrology,
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-15
  • Int'l Joint Research
• [Presentation] IFI27/ ISG12A in peripheral white blood cells is a useful marker for IgA nephropathy (2016)
  • Author(s): Yasuyuki Nagasawa, Daisuke Okuzaki, Eri Muso, Ryohei Yamamoto, Maki Shinzawa, Yukako Iwasaki, Hirotsugu Iwatani, Takeshi Nakanishi, Yoshitaka Isaka, Hiroshi Nojima
  • Organizer: EDTA-ERA 53rd Congress,
  • Place of Presentation: Vienna,Austlia
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] Prevalence of Cancer in Membranous nephropathy patients (2015)
  • Author(s): Yasuyuki Nagasawa, , Sayuri Kawada, Mana Yahiro, Tomoko Kimura, Kiyoko Yamamoto, Aritoshi Kida, Yoshimasa Nanami, Yukiko Hasuike, Takayuki Kuragano, , Takeshi Nakanishi
  • Organizer: Annual meeting of American Society of Nephrology
  • Place of Presentation: San Diago, USA
  • Year and Date: 2015-11-05
• [Presentation] IgA腎症におけるガイドライン (2015)
  • Author(s): 長澤康行
  • Organizer: 日本腎臓学会西部学術大会
  • Place of Presentation: 金沢歌劇場（石川県、金沢市）
  • Year and Date: 2015-10-17
  • Invited
• [Presentation] 細菌感染のよるＩｇＡ腎症モデルマウスの作成の検討 (2015)
  • Author(s): 長澤 康行、大西智和、橋本雅仁, 川田 早百合、永井孝憲、木田 有利、
  • Organizer: 第５８回日本腎臓学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-06-06 – 2015-06-07
• [Presentation] 細菌感染のよるＩｇＡ腎症モデルマウスの作成の検討 (2015)
  • Author(s): 長澤 康行、大西智和、橋本雅仁, 川田 早百合、永井孝憲、木田 有利、名波 正義 ,蓮池 由起子、倉賀野 隆裕、中西 健
  • Organizer: 日本腎臓学会
  • Place of Presentation: 名古屋国際会議場（愛知県、名古屋市）
  • Year and Date: 2015-06-05
• [Presentation] OverviewＩｇＡ腎症 (2015)
  • Author(s): 長澤康行
  • Organizer: 日本腎臓学会
  • Place of Presentation: 名古屋国際会議場（愛知県、名古屋市）
  • Year and Date: 2015-06-05
  • Invited
• [Presentation] Prevalence of Cancer in Membranous nephropathy patients (2015)
  • Author(s): Yasuyuki Nagasawa, , Sayuri Kawada, Mana Yahiro, Tomoko Kimura, Kiyoko Yamamoto, Aritoshi Kida, Yoshimasa Nanami, Yukiko Hasuike, Takayuki Kuragano, , Takeshi Nakanishi
  • Organizer: European Ｎｅｐｈｒｏｌｏｇｙ，Ｄｉａｌｙｓｉｓ ａｎｄ Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ
  • Place of Presentation: London, UK
  • Year and Date: 2015-05-28
• [Presentation] ＩｇＡ腎症の発症と口腔内細菌のかかわり (2014)
  • Author(s): 長澤康行
  • Organizer: 第４４回日本腎臓学会西部学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-03 – 2014-10-04
  • Invited