Pulse waveform analysis of bidirectional aortic blood flow: Pathophysiological implications for target organ damage in hypertension
| Project/Area Number |
26461248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Miyagi University of Education (2016-2017)
Tohoku University (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 高血圧 / 大動脈 / 血流 / 臓器障害 / 腎機能 / 血行動態 / 動脈硬化 / 臨床病態学 |
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| Outline of Final Research Achievements |
This study investigated the pathogenic influence of aortic pulsatile flow on hypertensive target organ damage. Bidirectional pulse waveform of aortic flow velocity was noninvasively recorded in hypertensive patients to calculate the ratio of the early diastolic reverse velocity to the systolic forward velocity (the reverse flow ratio) and the aortic compliance. The aortic flow reversal was inversely associated with the estimated glomerular filtration rate, indicating its contribution to renal dysfunction caused by aortic stiffening. Also, the aortic compliance was associated with the aortic pressure decay during diastole and the subendocardial variability index, suggesting that decreased aortic compliance predisposes to myocardial ischemia. These results indicate that target organ damage in hypertension is potentially attributable to aortic stiffening-induced flow abnormalities.
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Report
(5 results)
Research Products
(49 results)
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[Presentation] 中心血圧の研究2016
Author(s)
橋本 潤一郎
Organizer
第39回日本高血圧学会総会(セミナー講演）
Place of Presentation
仙台国際センター（宮城県仙台市）
Year and Date
2016-10-01
Related Report
Invited
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[Presentation] 中心血圧測定の意義2016
Author(s)
橋本 潤一郎
Organizer
第80回日本循環器学会（モーニングレクチャー）
Place of Presentation
仙台国際センター（宮城県仙台市）
Year and Date
2016-03-20
Related Report
Invited
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[Presentation] 中心血行動態と高血圧性腎障害2015
Author(s)
橋本 潤一郎、伊藤 貞嘉
Organizer
第38回日本高血圧学会（シンポジウム発表）
Place of Presentation
愛媛県県民文化会館（愛媛県松山市）
Year and Date
2015-10-10
Related Report
Invited
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