| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
This study investigated the pathogenic influence of aortic pulsatile flow on hypertensive target organ damage. Bidirectional pulse waveform of aortic flow velocity was noninvasively recorded in hypertensive patients to calculate the ratio of the early diastolic reverse velocity to the systolic forward velocity (the reverse flow ratio) and the aortic compliance. The aortic flow reversal was inversely associated with the estimated glomerular filtration rate, indicating its contribution to renal dysfunction caused by aortic stiffening. Also, the aortic compliance was associated with the aortic pressure decay during diastole and the subendocardial variability index, suggesting that decreased aortic compliance predisposes to myocardial ischemia. These results indicate that target organ damage in hypertension is potentially attributable to aortic stiffening-induced flow abnormalities.
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