| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Using chronic kidney disease (CKD) model rat, we clarified renal sympathetic nerve is important in regulating cardiac calcium channel, SERCA, and controlling cardiac diastolic function. Our CKD model is uni-nephrectomized and high salt loaded rat and it developed diastolic dysfunction along with renal dysfunction. When renal sympathetic nerve is cut, cardiac dysfunction was recovered independent from blood pressure and renal function. mRNA expression of SERCA was also recovered by mechanical sympathectomy. Our preliminary study indicated that afferent sympathetic nerve is essential in this recover of cardiac function. In addition, prostaglandin E from kidney may modulate cardiac function.
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