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Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive Rats

Research Project

Project/Area Number 26461250
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionOsaka University

Principal Investigator

Koriyama Hiroshi  大阪大学, 医学系研究科, 助教 (60710093)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords高血圧症 / アンジオテンシンII / ワクチン
Outline of Final Research Achievements

The aim of this study was to design DNA vaccines for high blood pressure and eventually develop human vaccine therapy to treat hypertension. Plasmid vector encoding hepatitis B core-angiotensin II (Ang II) fusion protein was injected into spontaneously hypertensive rats using needleless injection system. Anti-Ang II antibody was successfully produced in hepatitis B core-Ang II group. Systolic blood pressure was consistently lower in hepatitis B core-Ang II group after immunization, whereas blood pressure reduction was continued for at least 6 months. Survival rate was significantly improved in hepatitis B core-Ang II group. This study demonstrated that Ang II DNA vaccine to spontaneously hypertensive rats significantly lowered high blood pressure for at least 6 months. In addition, Ang II DNA vaccines induced an adequate humoral immune response while avoiding the activation of self-reactive T cells, assessed by ELISPOT assay.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive Rats.2015

    • Author(s)
      Koriyama H, et. al
    • Journal Title

      Hypertension

      Volume: 66 Issue: 1 Pages: 167-174

    • DOI

      10.1161/hypertensionaha.114.04534

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 高血圧症に対するアンジオテンシンⅡワクチンによる新規治療法の開発2016

    • Author(s)
      郡山弘
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] The development of Angiotension II vaccine for hypertension2016

    • Author(s)
      郡山弘
    • Organizer
      HYPERTENSION SUMMIT 2016
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アンジオテンシンIIワクチンの開発2015

    • Author(s)
      郡山 弘
    • Organizer
      第23回日本血管生物医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] アンジオテンシンIIワクチンによる高血圧症の新規治療法の開発2015

    • Author(s)
      郡山 弘
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 次世代バイオロジクスとしての治療ワクチン開発2014

    • Author(s)
      郡山 弘
    • Organizer
      第1回最先端医療イノベーションセンターシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] The Development of Angiotensin II Vaccine for Hypertension2014

    • Author(s)
      郡山 弘
    • Organizer
      第2回Premium Hypertension Conference
    • Place of Presentation
      東京
    • Year and Date
      2014-08-09
    • Related Report
      2014 Research-status Report
  • [Presentation] アンジオテンシンⅡを標的としたワクチンによる高血圧症の新規治療法の開発2014

    • Author(s)
      郡山 弘
    • Organizer
      第14回日本抗加齢医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 高血圧症に対するワクチンによる新規治療法の開発2014

    • Author(s)
      郡山 弘
    • Organizer
      第1回ResearchPlaNet
    • Place of Presentation
      東京
    • Year and Date
      2014-05-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of Angiotensin II Vaccine for Hypertension2014

    • Author(s)
      郡山 弘
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      京都
    • Year and Date
      2014-04-15
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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