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Elucidation the mechanism of progression on peritoneal sclerosis in peritoneal dialysis

Research Project

Project/Area Number 26461252
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionOkayama University

Principal Investigator

KITAMURA SHINJI  岡山大学, 大学病院, 講師 (70467752)

Research Collaborator TSUJI KENZI  
TORII AKIKO  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords腹膜中皮細胞 / 腹膜透析 / 細胞療法 / 腹膜再生
Outline of Final Research Achievements

In Vitro study, peritoneal mesothelial cells were performed the morphological and qualitative evaluation. The cells used were peritoneal mesothelial cells, with cobblestone morphologic cells (Epi cells) and fibroblast-like peritoneal mesothelial cells (Fib cells). From the result, it is suggested that Fib cells play an important role in peritoneal sclerosis although Epi cells change poorly not only in acidic stimulation but also in sugar stimulation.
In vivo study, Epi cell supernatant significantly improved peritoneal damage and peritoneal adhesion compared to the peritoneal sclerosis positive model, however in Fib cell supernatants, peritoneal deterioration were significantly observed. From these results, it is suggested that secreted factor from peritoneal mesothelial cells is also important. We will also conduct exosome analysis in secreted factors to aim for elucidation of its mechanism.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (3 results)

  • [Journal Article] The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome.2017

    • Author(s)
      Inoue-Torii A, Kitamura S, Wada J, Tsuji K, Makino H.
    • Journal Title

      Int J Nephrol Renovasc Dis.

      Volume: 10 Pages: 167-174

    • DOI

      10.2147/ijnrd.s132980

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trophic Factors from Tissue Stem Cells for Renal Regeneration.2015

    • Author(s)
      Tsuji K, Kitamura S
    • Journal Title

      Stem Cells Int.

      Volume: 2015 Pages: 537204-537204

    • DOI

      10.1155/2015/537204

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Single Adult Kidney Stem/Progenitor Cells Reconstitute 3-Dimensional Nephron Structures in Vitro.2015

    • Author(s)
      Kitamura S, Sakurai H, Makino H
    • Journal Title

      Stem Cells

      Volume: 33 Issue: 3 Pages: 774-784

    • DOI

      10.1002/stem.1891

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-inducible factor 1α regulates branching morphogenesis during kidney development.2014

    • Author(s)
      Tsuji K, Kitamura S, Makino H
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 25 Issue: 1 Pages: 108-114

    • DOI

      10.1016/j.bbrc.2014.03.111

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] The selected peritoneal mesothelial cell therapy is effective to prevent peritoneal fibrosis2016

    • Author(s)
      shinji kitamura
    • Organizer
      34th Congress of the International Society of Blood Purification
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 慢性腎臓病から透析までの包括的腎臓領域再生医療に向けて2016

    • Author(s)
      喜多村真治
    • Organizer
      第61回日本透析医学会学術集会・総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-06-12
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] The selection of peritoneal mesothelial cells is important for cell therapy to prevent peritoneal fibrosis2015

    • Author(s)
      喜多村真治
    • Organizer
      第60回日本透析医学会学術集会・総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-06-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Single adult kidney stem/progenitor cells reconstitute 3-dimensional nephron structures2015

    • Author(s)
      喜多村真治
    • Organizer
      岡山医学会総会
    • Place of Presentation
      岡山プラザホテル
    • Year and Date
      2015-06-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 成体腎臓幹/前駆細胞の分泌因子による再生機序の解明2014

    • Author(s)
      辻憲二、 喜多村真治、 井上章子、前島洋平、杉山斉、槇野博史
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 尿中Semapforin3Aは微小変化型ネフローゼ症候群の活動性を反映する2014

    • Author(s)
      井上章子、喜多村真治、辻憲二、前島洋平、杉山斉、槇野博史
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Research-status Report
  • [Presentation] SECRET FACTORS FROM ADULT KIDNEY STEM/PROGENITOR CELLS CONTRIBUTE TO REGENERATION.2014

    • Author(s)
      Kenji Tsuji, Shinji Kitamura and Hirofumi Makino
    • Organizer
      The 14th Asia Pacific Congress of Nephrology 2014
    • Place of Presentation
      品川プリンスホテル、東京
    • Year and Date
      2014-05-14 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Presentation] URINRY SEMAPHORIN3A IS RELATED TO THE ACTIVITY OF MINOR CHANGE NEPHROTIC SYNDROME.2014

    • Author(s)
      Inoue Akiko, Kenji Tsuji, Shinji Kitamura, Hirofumi Makino
    • Organizer
      The 14th Asia Pacific Congress of Nephrology 2014
    • Place of Presentation
      品川プリンスホテル、東京
    • Year and Date
      2014-05-14 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Book] 小児外科49巻5号2017

    • Author(s)
      喜多村 真治
    • Total Pages
      120
    • Publisher
      東京医学社
    • Related Report
      2017 Annual Research Report
  • [Book] Nephrology Frontier Vol.14 No.22015

    • Author(s)
      喜多村真治
    • Total Pages
      196
    • Publisher
      メディカルレヴュー社
    • Related Report
      2015 Research-status Report
  • [Book] 腎と透析2014

    • Author(s)
      喜多村真治
    • Total Pages
      4
    • Publisher
      東京医学社
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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