| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Hyperphosphatemia is linked to vasclular calcification with chronic kidney disease (CKD) and an independent risk factor for cardiovascular mortality in haemodialysis patients. In CKD patients, plasma phosphate (Pi) control is essential for improving life prognosi.
Osteocytes are known as endocrine cells because osteocytes secrete FGF23 (Fibroblast growth factor 23) as phosphate regulating factors. Osteocytes make osteocytic canaliculi-osteocyte network through dendrites in osteocytic canaliculi to each other. We hypothesized that the osteocyte network controls plasma Pi levels and dietary Pi sensing. The osteocyte network disrupted mice did not respond loading high Pi diet. In osteocyte network disrupted mice, renal fibrosis and ectopic calcification were observed. Thus, we suggested that osteocyte is a sensory cell for dietary Pi loading. We show that maintenance of the number of osteocyte leads to preveting CKD progression and ectopic calcification.
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