| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
According to molecular genetic analyses of both familial and hereditary hypertension by R.C.Lifton and J.M.Lalouel, imapairments of sodium reabsorption along tubules are primarily responsible for hypertension. Principal investigator performed molecular pathophysiological analyses of salt sensitivity and hypertension focusing on epithelial sodium channels and their characteristic ubiquitinating enzyme, Nedd4-2/L. We developped Nedd4-2 C2 KO mice and our analyses revealed aberrant ENaC gene activations with enhanced sodium reabsorption are basically pivotal for progression and promotion of salt sensitivity and hypertension.
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