Elucidation and Expansion of Molecular Physiology of Salt Sensitivity and Hypertensin Based on Tubular Mechanism.
| Project/Area Number |
26461257
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食塩感受性 / 高血圧 / 上皮性ナトリウムチャネル / ユビキチン化 / Nedd4-2 / アミロライド / 尿細管 / イオントランスポーター / ユビキチン / アンジオテンシノーゲン / レニン・アンジオテンシン系 / レニン |
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| Outline of Final Research Achievements |
According to molecular genetic analyses of both familial and hereditary hypertension by R.C.Lifton and J.M.Lalouel, imapairments of sodium reabsorption along tubules are primarily responsible for hypertension. Principal investigator performed molecular pathophysiological analyses of salt sensitivity and hypertension focusing on epithelial sodium channels and their characteristic ubiquitinating enzyme, Nedd4-2/L. We developped Nedd4-2 C2 KO mice and our analyses revealed aberrant ENaC gene activations with enhanced sodium reabsorption are basically pivotal for progression and promotion of salt sensitivity and hypertension.
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Report
(4 results)
Research Products
(13 results)
