| Project/Area Number |
26461258
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Chiba University (2015-2016)
Dokkyo Medical University (2014) |
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Principal Investigator |
Anzai Naohiko 千葉大学, 大学院医学研究院, 教授 (70276054)
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| Co-Investigator(Kenkyū-buntansha) |
JUTABHA Promsuk 獨協医科大学, 医学部, 助教 (90541748)
大内 基司 獨協医科大学, 医学部, 准教授 (20409155)
大谷 直由 獨協医科大学, 医学部, 助教 (60711819)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Motoyasu 獨協医科大学, 医学部, 助教 (20418891)
OHBAYASHI Tetsuya 鳥取大学, 生命機能研究支援センター, 准教授 (80348804)
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| Research Collaborator |
HAYASHI Keitaro
MORITA Asuka
NOHARA Masakatsu
WAKASHIN Hidefumi
TSUCHIYA Go
HORI Takayuki
KANO Yuji
ONIZAWA Nobuyuki
OTSUKA Yusuke
OHNO Yuta
Wempe Michael F.
ENDOU Hitoshi
KIMURA Toru
TAMAI Ikumi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 尿酸 / 高尿酸血症 / 膜輸送 / トランスポーター / 創薬 |
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| Outline of Final Research Achievements |
This study was aimed to investigate the effectiveness of a novel concept "3-factor model (3F)" and to make an alternative possibility for the development of new drugs that have less side effects regarding drug-induced hyperuricemia. For developing appropriate materials for evaluating this concept that may express triple urate transporters such as URAT1, URATv1, and NPT4, we performed a collaborative study with Dr. Tetsuya Ohbayashi who is a specialist of a mammalian artificial chromosome vector that can be used for introducing multiple genes and succeded to express several kidney-derived genes using his system onto our mouse-derived renal tubular cell named S2. We will use this protocol for further analysis. In addition, we could raise a new animal model that can be used for analyzing the concept of 3F by using pyrazinamide-loading method for creating renal-underexcretion hyperuricemia model.
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