| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Transplanted mesothelial cells into peritoneal cavity aggravated peritoneal injury while progressing peritoneal fibrosis and infiltrating inflammatory cells. However, adipose tissue stem cells (ADSCs) suppressed fibrosis and promote peritoneal repair. Mesothelial cells (MCs) pre-treated with anti-oxidative agent showed resistant to stimulation (peritoneal dialysate) derive epithelial-mesothelial transition (EMT) and production of inflammatory cytokines and growth factors. Furthermore, EMT and production of inflammatory cytokines and growth factors were suppressed in co-culture of ADSCs and MCs under stimulation, and supernatant derived from stimulated ADSCs also inhibited EMT in mesothelial cells against peritoneal dialysate. These results suggested that endocrine effect of ADSCs to mesothelial cells, component cells in peritoneum one of mechanism to promote tissue repair in injured peritoneum.
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