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A study on propagation of cerebral b-amyloidosis with protein contained in foods and cosmetics

Research Project

Project/Area Number 26461267
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKanazawa University

Principal Investigator

Hamaguchi Tsuyoshi  金沢大学, 附属病院, 講師 (70452109)

Co-Investigator(Kenkyū-buntansha) 小野 賢二郎  金沢大学, 附属病院, 講師 (70377381)
山田 正仁  金沢大学, 医学系, 教授 (80191336)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsアルツハイマー病 / 化粧品 / 食品 / アミロイド / 食物
Outline of Final Research Achievements

We reported that casein, fibroin, siren, and actin, which are contained in foods or cosmetics, could promote amyloid b protein fibril formation in vitro. The objective of this study is to investigate whether the fibrils of these peptides can promote cerebral b-amyloidosis in vivo. We made the fibrils of casein and actin in vitro, and injected them into Alzheimer's disease (AD) model mouse brain. Furthermore, intraperitoneal injection was also performed. One year after the injections, we evaluated amyloid b protein (Ab) deposition in the mice brain. We found a little Ab deposition on the blood vessels in AD model mice injected casein into the brain. We will continue to evaluate Ab deposition of the mice brains.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Progression of seed-induced Aβ deposition within the limbic connection2015

    • Author(s)
      Ye L, Hamaguchi T, Fritschi SK, Eisele YS, Obermuller U, Jucker M, Walker LC
    • Journal Title

      Brain Pathol

      Volume: - Issue: 6 Pages: 743-752

    • DOI

      10.1111/bpa.12252

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple factors contribute to the peripheral induction of cerebral β-anyloidosis2014

    • Author(s)
      Eisele YS*, Fritschi SK*, Hamaguchi T*, Obermuller U, Fuger P, Skodras A, Schafer C, Odenthal J, Heikenwalder M, Staufenbiel M, Jucker M
    • Journal Title

      J Neurosci

      Volume: 34 Issue: 31 Pages: 10264-10273

    • DOI

      10.1523/jneurosci.1608-14.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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