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Analysis for mechanism of spontaneous seizures in a rat model of multiple prenatal freeze lesioning and development of novel treatment for epilepsy focusing on connexin

Research Project

Project/Area Number 26461273
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKurume University (2016)
Kyushu University (2014-2015)

Principal Investigator

Kamada Takashi  久留米大学, 医学部, 助教 (70614460)

Co-Investigator(Kenkyū-buntansha) 高瀬 敬一郎  九州大学, 医学研究院, 共同研究員 (00467903)
山口 浩雄  九州大学, 大学病院, 講師 (00701830)
重藤 寛史  九州大学, 医学研究院, 共同研究員 (50335965)
真崎 勝久  九州大学, 医学研究院, 助教 (90612903)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsてんかん / 皮質異形成 / コネキシン蛋白群 / てんかん動物モデル / 動物モデル / 海馬
Outline of Final Research Achievements

In a previous study we created an animal model with multiple FCD, produced by freeze lesioning during embryonic development, showing hippocampal spontaneous seizures. Recently, involvement of chronic inflammation and excessive intercellular network with connexin has been pointed out as a mechanism for development of epilepsy. In this study, we analyzed the expression of receptors and inflammatory cytokines related to chronic inflammation and connexin in the hippocampus and cortex after the onset of epilepsy in this animal model. Semiquantitative densitometry of immunoreactivity revealed increased IL-1β, Cx32, Cx43 expression in hippocampus and GFAP, TLR4, IL-1β, Cx32, Cx36, Cx43 expression in lesioned cortices. The mechanism for development of hippocampal epileptogenesis with cortical dysplasia was suggested to be an abnormal excitatory network circuit involving chronic inflammation and connexin.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (1 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] Spontaneous seizures in a rat models of multiple prenatal lesioning2014

    • Author(s)
      Kamada T
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 54 Issue: 12 Pages: 1132-1135

    • DOI

      10.5692/clinicalneurol.54.1132

    • NAID

      130004921154

    • ISSN
      0009-918X, 1882-0654
    • Related Report
      2014 Research-status Report
  • [Presentation] 一側頸部~上肢の有痛性体性感覚発作を繰り返した頭頂葉てんかんの一例2016

    • Author(s)
      鎌田 崇嗣
    • Organizer
      日本神経学会九州地方会
    • Place of Presentation
      九州大学医学部
    • Year and Date
      2016-03-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 左前側頭部に高振幅てんかん性放電の出現を認めた側頭葉てんかんの一例2015

    • Author(s)
      鎌田 崇嗣
    • Organizer
      日本臨床神経生理学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 長時間持続する限局性のてんかん性放電を認めた前頭葉てんかんの2症例2015

    • Author(s)
      鎌田 崇嗣
    • Organizer
      日本てんかん学会
    • Place of Presentation
      長崎新聞文化ホール
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 海馬体に近接した神経節膠腫を認めた側頭葉てんかんの一例2015

    • Author(s)
      鎌田 崇嗣
    • Organizer
      日本神経学会九州地方会
    • Place of Presentation
      長崎大学医学部
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 長時間持続する限局性のてんかん性放電を認めた脳膿瘍後前頭葉てんかんの一例2015

    • Author(s)
      鎌田 崇嗣
    • Organizer
      日本てんかん学会九州地方会
    • Place of Presentation
      大分大学医学部
    • Year and Date
      2015-07-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 巨大くも膜嚢胞を認めた側頭葉てんかんの一例2015

    • Author(s)
      鎌田 崇嗣
    • Organizer
      日本神経学会九州地方会
    • Place of Presentation
      熊本大学医学部
    • Year and Date
      2015-06-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 右側頭部にてんかん性放電を認めた恐怖感を呈する精神発作の一例2015

    • Author(s)
      鎌田 崇嗣
    • Organizer
      第209回日本神経学会 九州地方会
    • Place of Presentation
      福岡大学メディカルホール
    • Year and Date
      2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 長時間持続する限局性のてんかん性放電を認めた脳膿瘍後前頭葉てんかんの一例2014

    • Author(s)
      鎌田 崇嗣
    • Organizer
      第208回日本神経学会 九州地方会
    • Place of Presentation
      琉球大学医学部
    • Year and Date
      2014-12-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 自発てんかん発作を有した皮質異形成ラットモデル2014

    • Author(s)
      鎌田 崇嗣
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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