Pathomechanism of cerebral small vessel disease due to disturbance of transendocytosis
| Project/Area Number |
26461276
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
Mizuno Toshiki 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30264782)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
田中 雅樹 京都府立医科大学, 医学(系)研究科(研究院), 教授 (80264753)
水田 依久子 京都府立医科大学, 医学(系)研究科(研究院), 助教 (80397760)
大原 亮 京都府立医科大学, 医学(系)研究科(研究院), 助教 (80636986)
|
|---|
| Research Collaborator |
Mukai Mao 京都府立医科大学, 医学研究科, 大学院生
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | CADASIL / 遺伝性脳小血管病 / NOTCH3 / transendocytosis / Notch / 脳小血管病 / Notch3 / trasnendocytosis |
|---|
| Outline of Final Research Achievements |
The aim of this study is to clarify the pathomechanism of Cerebral Autosomal Dominant Arteriopathy with Sub- cortical Infarcts and Leukoencephalopathy (CADASIL). We hypothized that endocytosis into ligand expressing cell might be disturbed after activation of notch signaling in CADASIL We analyzed the endocytosis of fragment of NOTCH3 extracellular domain into transient Jagged1 expressing cell. The fragment of wild NOTCH3 extracellular domain was found in the Jagged1 expressing cell. In contrast, the fragment of mutant NOTCH3 extracellular domain was not found in the Jagged1 expressing cell. These results supported that endocytosis into ligand expressing cell is disturbed in CADASIL.
|
Report
(5 results)
Research Products
(28 results)
-
[Journal Article] New diagnostic criteria for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukocencephalopathy in Japan.2017
Author(s)
Mizuta I, Hosomi-Watanabe A, Koizumi T, Mukai M, Hamano A, Tomii Y, Kondo M, Nakagawa M, Tomimoto H, Hirano T, Uchino M, Onodera O, Mizuno T
-
Journal Title
J Neurol Sci
Volume: 381
Pages: 62-67
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
[Journal Article] A Japanese CADASIL kindred with a novel two-base NOTCH3 mutation.2016
Author(s)
Suda, Satoshi; Okubo, Seiji; Ueda, Masayuki; Sowa, Kota; Abe, Arata; Aoki, Junya; Muraga, Kanako; Suzuki, Kentaro; Sakamoto, Yuki; Mizuta, Ikuko; Mizuno, Toshiki; Kimura, Kazumi.
-
Journal Title
Eur J Neurol
Volume: 23
Issue: 5
Pages: 32-34
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL.2016
Author(s)
Nozaki H, Kato T, Nihonmatsu M, Saito Y, Mizuta I, Noda T, Koike R, Miyazaki K, Kaito M, Ito S, Makino M, Koyama A, Shiga A, Uemura M, Sekine Y, Murakami A, Moritani S, Hara K, Yokoseki A, Kuwano R, Endo N, Momotsu T, Yoshida M, Nishizawa M, Mizuno T, Onodera O
-
Journal Title
Neurology
Volume: 86
Issue: 21
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
