| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
I have revealed parkin, a protein related to pathogenesis of Parkinson's disease, is S-nitrosylated and its activity is regulated by S-nitrosylation. To investigate a role of S-nitrosylation of endogenous parkin in degeneration in Parkinson's disease, we generated cell lines which cysteine targeted by S-nitrosylation was converted to another amino acid. Using them, I revealed S-nitrosylation of endogenous parkin is not involved in degradaiton of mitochondria through autophagy but in cell death by mitochondrial stress. These findings indicated S-nitrosylation of parkin might play a important role in cell death by mitochondrial dysfunction and , at least in part, pathogenesis of Parkinson's disease.
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