Analysis of mutational mechanism of JC virus in patients with progressive multifocal leukoencephalopathy during mefloquine administration
Project/Area Number |
26461286
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
Nakamichi Kazuo 国立感染症研究所, ウイルス第一部, 主任研究官 (50348190)
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Co-Investigator(Renkei-kenkyūsha) |
SHIMOKAWA Toshio 和歌山県立医科大学, 臨床研究センター, 准教授 (00402090)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | ウイルス / 脳 / 神経 / 脳神経疾患 / 神経感染症 / 進行性多巣性白質脳症 / 感染症 |
Outline of Final Research Achievements |
Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease caused by JC polyomavirus (JCV) infection. JCV isolates from PML patients have variable mutations in the viral genome. In this study, we have comprehensively analyzed the mutational patterns of JCV isolates obtained from the cerebrospinal fluid of PML patients. We have also examined the relationship between JCV mutation and disease progression.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Progressive multifocal leukoencephalopathy after autologous peripheral blood stem cell transplantation in a patient with multiple myeloma treated with combination therapy2016
Author(s)
Yokokawa K, Hisahara S, Matsuura Y, Ikeda K, Tsuda E, Saitoh M, Nakamichi K, Saijo M, Kamihara Y, Sato T, Kawamata J, Shimohama S
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Journal Title
Journal of Neurological Science
Volume: 368
Pages: 304-306
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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