Microvascular pericytes: possible regenerative targets in ALS
Project/Area Number |
26461288
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 臨床神経分子遺伝学 / 神経再生 / 神経変性 / 運動ニューロン / ペリサイト |
Outline of Final Research Achievements |
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by systemic loss of motor neurons. In adult brain and spinal cord, endogenous regenerative responses cannot lead to sufficient tissue repair, although neural stem/progenitor cells reside along the central neuraxis. However, non-neuronal cells such as glial cells and microvascular components are activated and proliferate by various insults including neurodegeneration. In the present study, we examined a possible regenerative response in an ALS rat model. In contrast to controls, multiple immunohistochemistry revealed a significant increase of newborn microvascular pericytes in the ALS rat spinal cord. As compared with vehicle-treated group, intrathecal infusion of a maintaining factor for pericytes significantly augment the newborn pericytes and attenuated the loss of ventral horn neurons in the ALS rats. The pericytes may, therefore, be a novel therapeutic target in ALS.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Prominent sensory involvement in a case of familial amyotrophic lateral sclerosis carrying the L8V SOD1 mutation.2016
Author(s)
Nisiyama A, Warita H, Takahashi T, Suzuki N, Nishiyama S, Tano O, Akiyama T, Watanabe Y, Takahashi K, Kuroda H, Kato M, Tateyama M, Niihori T, Aoki Y, Aoki M.
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Journal Title
Clin Neurol Neurosurg
Volume: 150
Pages: 194-196
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation2015
Author(s)
Izumi R, Warita H, Niihori T, Takahashi T, Tateyama M, Suzuki N, Nishiyama A, Shirota M, Funayama R, Nakayama K, Mitsuhashi S, Nishino I, Aoki Y, Aoki M
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Journal Title
Neurol Genet
Volume: 1(3)
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Genetic profile for suspected dysferlinopathy identified by targeted next generation sequencing2015
Author(s)
Izumi R, Niihori T, Takahashi T, Suzuki N, Tateyama M, Watanabe C, Sugie K, Nakanishi H, Sobue G, Kato M, Warita H, Aoki Y, Aoki M
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Journal Title
Neurol Genet
Volume: 1(4)
Issue: 4
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Establishment of in vitro FUS-associated familial amyotrophic lateral sclerosis model using human induced pluripotent stem cells.2016
Author(s)
Ichiyanagi N, Fujimori K, Yano M, Fujisaki C, Sone T, Akiyama T, Okada Y, Akamatsu W, Matsumoto T, Ishikawa M, Nishimoto Y, Ishihara Y, Sakuma T, Yamamoto T, Tsuji H, Suzuki N, Warita H, Aoki M, Okano H.
Organizer
ISSCR 2016 Annual Meeting
Place of Presentation
San Francisco, CA, USA
Year and Date
2016-06-22
Related Report
Int'l Joint Research
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[Presentation] Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation.2016
Author(s)
Izumi R, Warita H, Niihori T, Takahashi T, Tateyama M, Suzuki N, Nishiyama A, Shirota M, Funayama R, Nakayama K, Mitsuhashi S, Nishino I, Aoki Y, Aoki M.
Organizer
The 13th International Congress of Human Genetics
Place of Presentation
Kyoto, Japan
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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[Presentation] Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation2016
Author(s)
Izumi R, Warita H, Niihori T, Takahashi T, Tateyama M, Suzuki N, Nishiyama A, Shirota M, Funayama R, Nakayama K, Mitsuhashi S, Nishino I, Aoki Y, Aoki M
Organizer
The 13th International Congress of Human Genetics
Place of Presentation
Kyoto(国立京都国際会館)
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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