Analysis of granulocytes in inflammatory autoimmune disorders of the central nervous system
Project/Area Number |
26461289
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Niigata University |
Principal Investigator |
KAWACHI Izumi 新潟大学, 医歯学総合病院, 講師 (40432083)
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Co-Investigator(Kenkyū-buntansha) |
豊島 靖子 新潟大学, 脳研究所, 准教授 (20334675)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 視神経脊髄炎 / 多発性硬化症 / アクアポリン4水チャネル / 顆粒球系細胞 / 神経病態免疫学 |
Outline of Final Research Achievements |
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS). Accumulation of granulocytes, macrophages and tissue-resident lymphocytes was evident in early active lesions with a pattern-specific loss of aquaporin-4 (AQP4) immunoreactivities in NMOSD cases. These lesions had widespread neuroaxonal damage with axonal degenerative mitochondria, via abnormal AQP4 dynamics on astrocytes. These data suggest that unique dynamics of AQP4 autoantibodies and immune cells including granulocytes might cooperate to form massive damages of the CNS and cause severe physical and visual disabilities in NMOSD.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Clinicopathological features in anterior visual pathway in neuromyelitis optica2016
Author(s)
Hokari M, Yokoseki A, Arakawa M, Saji E, Yanagawa K, Yanagimura F, Toyoshima Y, Okamoto K, Ueki S, Hatase T, Ohashi R, Fukuchi T, Akazawa K, Yamada M, Kakita A, Takahashi H, Nishizawa M, Kawachi I.
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Journal Title
Annals of Neurology
Volume: 79
Issue: 4
Pages: 605-624
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Efficacy of intravenous methylprednisolone pulse therapy in patients with multiple sclerosis and neuromyelitis optica2016
Author(s)
Yamasaki R, Matsushita T, Fukazawa T, Yokoyama K, Fujihara K, Ogino M, Yokota T, Miyamoto K, Niino M, Nomura K, Tomioka R, Tanaka M, Kawachi I, Ohashi T, Kaida KI, Matsui M, Nakatsuji Y, Ochi H, Fukaura H, Kanda T, Nagaishi A, Togo K, Mizusawa H, Murai H, Kira JI
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Journal Title
Multiple sclerosis
Volume: 印刷中
Issue: 10
Pages: 1337-1348
DOI
Related Report
Peer Reviewed
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[Presentation] NMO is characterized by serious attacks and neurodegeneration with abnormal mitochondria.2016
Author(s)
Hokari M, Yokoseki A, Saji E, Arakawa M, Yanagawa K, Yanagimura F, Toyoshima Y, Kakita A, Takahashi H, Nishizawa M, Kawachi I.
Organizer
第57回日本神経学会学術大会
Place of Presentation
神戸コンベンションセンター (兵庫県神戸市)
Year and Date
2016-05-18
Related Report
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[Presentation] Severe neurodegeneration and unique dynamics of astrocytes/Muller cells with alterations of aquaporin-4 in neuromyelitis optica2016
Author(s)
Kawachi I, Hokari M, Yokoseki A, Arakawa M, Saji E, Yanagawa K, Yanagimura F, Toyoshima Y, Kakita A, Takahashi H, Nishizawa M
Organizer
8th Annual Neuromyelitis optica roundtable conference (Guthy Jackson Charitable Foundation)
Place of Presentation
Los Angeles, CA, USA
Year and Date
2016-02-29
Related Report
Int'l Joint Research / Invited
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