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Extensive disruption of energy transports via glial syncytium in demyelinating diseases

Research Project

Project/Area Number 26461295
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKyushu University

Principal Investigator

Masaki Katsuhisa  九州大学, 医学研究院, 助教 (90612903)

Co-Investigator(Kenkyū-buntansha) 山口 浩雄  九州大学, 大学病院, 講師 (00701830)
山崎 亮  九州大学, 医学研究院, 准教授 (10467946)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords多発性硬化症 / 視神経脊髄炎 / グリアシンシチウム / 栄養供給障害 / コネキシン / 栄養トランスポーター / グリアアセンブリ / エネルギー供給障害
Outline of Final Research Achievements

Neuropathological analysis of connexins in MS, NMO, Balo disease was completed. In the spinal cord of NMO, isolated perivascular lesion was frequently found in white matter. We also found that humoral factors derived from Th1 cells decreased the expression of Cx43. We found that the expressions of Cx47 and Cx32 were markedly diminished in oligodendrocytes of spinal gray matter in mutant SOD1-Tg mice.
We investigated the expression pattaren of glucose lactate transporters in demyelinating disorders and found the decreased expression of astrocyte MCT4 in active demyelinating lesions. GLUT1 and MCT1 expressed on the vascular endothelium are retained, and our findings indicated that nutrient supply impairment via glial cells is present in demyelinating diseases.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (30 results)

All 2016 2015 2014 2013

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Acknowledgement Compliant: 3 results,  Open Access: 5 results) Presentation (13 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results) Book (4 results)

  • [Journal Article] Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation.2016

    • Author(s)
      Yamasaki R, et al
    • Journal Title

      J Neurosci

      Volume: 36 Pages: 11929-11945

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minocycline-induced human herpesvirus 6 encephalomyelitis with drastically disseminated contrast-enhanced lesions.2016

    • Author(s)
      Shinoda K, et al
    • Journal Title

      Eur J Neurol

      Volume: 23 Issue: 12 Pages: 76-77

    • DOI

      10.1111/ene.13190

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation2016

    • Author(s)
      Watanabe M, Masaki K, Yamasaki R, Kawanokuchi J, Takeuchi H, Matsushita T, Suzumura A, Kira JI.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 38387-38387

    • DOI

      10.1038/srep38387

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Antibodies to myelin oligodendrocyte glycoprotein are uncommon in Japanese opticospinal multiple sclerosis.2016

    • Author(s)
      Ramanathan S, et al
    • Journal Title

      Mult Scler

      Volume: 22 Issue: 1 Pages: 127-128

    • DOI

      10.1177/1352458515586089

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Early and Extensive Spinal White Matter Involvement in Neuromyelitis Optica.2015

    • Author(s)
      Hayashida S, et al
    • Journal Title

      Brain Pathol

      Volume: in press Issue: 3 Pages: 249-265

    • DOI

      10.1111/bpa.12386

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Japan Multiple Sclerosis Genetics Consortium Copy Number Variations in Multiple Sclerosis and Neuromyelitis Optica.2015

    • Author(s)
      S. Sato, K. Yamamoto, T. Matsushita, N. Isobe, Y. Kawano, K, Iinuma, M. Niino, T. Fukazawa, Y. Nakamura, M. Watanabe, T. Yonekawa, K. Masaki, S. Yoshimura, H. Murai, R. Yamasaki, J. Kira
    • Journal Title

      Annals of Neurology

      Volume: 78 Issue: 5 Pages: 762-774

    • DOI

      10.1002/ana.24511

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early disruption of glial communication via connexin gap junction in multiple sclerosis, Baló's disease and neuromyelitis optica.2015

    • Author(s)
      Masaki K
    • Journal Title

      Neuropathology

      Volume: 35 Issue: 5 Pages: 469-480

    • DOI

      10.1111/neup.12211

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Peripheral blood T cell dynamics predict relapse in multiple sclerosis patients on fingolimod2015

    • Author(s)
      Song ZY, Yamasaki R, Kawano Y, Sato S, Masaki K, Yoshimura S, Matsuse D, Murai H,Matsushita T, Kira J
    • Journal Title

      PLoS One

      Volume: 10 Issue: 4 Pages: e0124923-e0124923

    • DOI

      10.1371/journal.pone.0124923

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased serum vitamin D levels in Japanese patients with multiple sclerosis.2015

    • Author(s)
      Niino M, Sato S, Fukazawa T, Masaki K, Miyazaki Y, Matsuse D, Yamasaki R, Takahashi E, Kikuchi
    • Journal Title

      Journal of neuroimmunology

      Volume: 279 Pages: 40-45

    • DOI

      10.1016/j.jneuroim.2015.01.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model.2014

    • Author(s)
      Cui Y and Masaki K et al
    • Journal Title

      J Neuroinflammation

      Volume: 11 Issue: 1 Pages: 42-42

    • DOI

      10.1186/1742-2094-11-42

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased CCR2 and CD62L expressions on peripheral blood classical monocytes in amyotrophic lateral sclerosis.2014

    • Author(s)
      Cui Y, et al.
    • Journal Title

      Clin Exp Neuroimmunol

      Volume: 5 Issue: 1 Pages: 92-96

    • DOI

      10.1111/cen3.12088

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients.2014

    • Author(s)
      Yoshimura S, Isobe N, Matsushita T, Masaki K, Sato S, Kawano Y, Ochi H, Kira J.
    • Journal Title

      PLoS One

      Volume: 9(4) Issue: 4 Pages: e95367-e95367

    • DOI

      10.1371/journal.pone.0095367

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A nationwide survey of hypertrophic pachymeningitis in Japan2013

    • Author(s)
      Yonekawa T, Murai H, Utsuki S, Matsushita T, Masaki K, Isobe N, Yamasaki R, Yoshida M, Kusunoki S, Sakata K, Fujii K, Kira J
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 85 Issue: 7 Pages: 732-9

    • DOI

      10.1136/jnnp-2013-306410

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Immunopathological Study of Glucose and Lactate Transporters in White and Gray Matter Lesions of Multiple Sclerosis and Neuromyelitis Optica2016

    • Author(s)
      Masaki K, et al
    • Organizer
      141st Annual Meeting of the American Neurological Association
    • Place of Presentation
      Baltimore
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多発性硬化症、視神経脊髄炎におけるグルコース・乳酸担体の神経病理学的検討2016

    • Author(s)
      眞﨑勝久ら
    • Organizer
      第28回日本神経免疫学会学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Extensive loss of astrocytic monocarboxylate transporter 4 in demyelinating diseases2016

    • Author(s)
      Masaki K, et al
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Common and distinct features of immunopathology between MS and NMO2015

    • Author(s)
      Masaki K
    • Organizer
      PACTRIMS 2015
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Extensive loss of astrocytic monocarboxylate transporter 4 in active lesions of multiple sclerosis and neuromyelitis optica2015

    • Author(s)
      Masaki K, et al
    • Organizer
      ECTRIMS 2015
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-10-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 多発性硬化症、視神経脊髄炎におけるグルコース・乳酸担体の神経病理学的検討2015

    • Author(s)
      眞﨑勝久ら
    • Organizer
      第27回日本神経免疫学会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 多発性硬化症、視神経脊髄炎におけるグルコース・乳酸担体の神経病理学的検討2015

    • Author(s)
      眞﨑勝久ら
    • Organizer
      第56回日本神経学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] A combined neuroimaging and neuropathological study for longitudinally extensive spinal cord lesions in neuromyelitis optica2015

    • Author(s)
      Hayashida S, et al
    • Organizer
      AAN 2015
    • Place of Presentation
      Washington, USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neuropathological study of glucose and monocarboxylate transporters in multiple sclerosis.2014

    • Author(s)
      眞﨑勝久
    • Organizer
      ECTRIMS 2014
    • Place of Presentation
      BOSTON
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] MSにおけるastrocytopathy2014

    • Author(s)
      眞﨑勝久
    • Organizer
      第26回日本神経免疫学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2014-09-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 脱髄性疾患における広汎なコネキシン脱落と病態への関与2014

    • Author(s)
      眞﨑勝久
    • Organizer
      第55回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Connexin Gap Junction Pathology in active MS, Baló’s disease and NMO.2014

    • Author(s)
      眞﨑勝久
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 脱髄性疾患におけるグルコース・乳酸トランスポーター発現の神経病理学的検討2014

    • Author(s)
      眞﨑勝久
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21
    • Related Report
      2014 Research-status Report
  • [Book] 最新医学2016

    • Author(s)
      眞﨑勝久
    • Total Pages
      10
    • Publisher
      最新医学社
    • Related Report
      2016 Annual Research Report
  • [Book] 免疫性神経疾患 病態と治療のすべて2015

    • Author(s)
      眞﨑勝久
    • Total Pages
      551
    • Publisher
      中山書店
    • Related Report
      2015 Research-status Report
  • [Book] 免疫性神経疾患 基礎・臨床研究の最新知見2015

    • Author(s)
      眞﨑勝久
    • Total Pages
      883
    • Publisher
      日本臨床社
    • Related Report
      2015 Research-status Report
  • [Book] 免疫症候群(第2版)Ⅰ2015

    • Author(s)
      眞﨑勝久
    • Total Pages
      931
    • Publisher
      日本臨床社
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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