Clinical and histological features of inflammatory myopathies mediated by autoantibodies
Project/Area Number |
26461298
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Keio University |
Principal Investigator |
Suzuki Shigeaki 慶應義塾大学, 医学部(信濃町), 講師 (50276242)
|
Research Collaborator |
NISHINO Ichizo
OHNUKI Yuko
WATANABE Yurika
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | 自己抗体 / 炎症性筋疾患 / 免疫介在性壊死性ミオパチー / SRP / HMGCR / 壊死性ミオパチー / 壊死性筋症 / スタチン / 筋病理 / 免疫沈降法 |
Outline of Final Research Achievements |
Immune-mediated necrotizing myopathy (IMNM) is a pathological entity characterized by necrosis in the absence of prominent endomysial lymphocytic infiltration. Autoantibodies against signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are associated with IMNM. The frequencies of anti-SRP and anti-HMGCR antibodies in patients with IMNM were 39% and 25%, respectively. Severe limb muscle weakness, neck weakness, dysphagia, respiratory insufficiency, and muscle atrophy were more frequently observed in patients with anti-SRP antibodies than with anti-HMGCR antibodies. HLA-DRB1 genotyping revealed the association of anti-SRP antibodies with DRB1*08:03 and that of anti-HMGCR antibodies with DRB1*11:01.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Pediatric necrotizing myopathy associated with anti-3-hydroxy-3-methylglutary coenzyme A reductase antibodies2017
Author(s)
Liang WC, Uruha A, Suzuki S, Murakami N, Takeshita E, Chen WZ, Jong WJ, Endo Y, Komaki H, Fujii T, Sekine H, Suzuki Y, Kawano Y, Mori-Yoshimura M, Oya Y, Xi J, Zhu W, Zhao C, Watanabe Y, Ikemoto K, Nishikawa A, Hamanaka K, Mitsuhashi S, Suzuki N, Nishino I.
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Journal Title
Rheumatology
Volume: 56
Issue: 2
Pages: 287-293
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] HLA-DRB1 alleles in immune-mediated necrotizing myopathy.2016
Author(s)
Ohnuki Y, Suzuki S, Shiina T, Uruha A, Watanabe Y, Suzuki S, Izumi S, Nakahara J, Hamanaka K, Takayama K, Suzuki N, Nishino I.
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Journal Title
Neruology
Volume: 87
Issue: 18
Pages: 1954-1955
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Statins and myotoxic effects associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase autiantibodies: an observational study in Japan2015
Author(s)
Watanabe Y, Suzuki S, Nishimura H, Murata K, Kurashige T, Ikawa M, Asahi M, Konishi H, Mitsuma S, Kawabata S, Suzuki N, Nishino I
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Journal Title
Medicine
Volume: 94
Issue: 4
Pages: e416-e416
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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