| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Immune responses following stroke appears an important factor for tissue damages. Our previous studies have shown that innate immune responses, including infiltrating macrophages and γδT lymphocytes, lead to deterioration of ischemic damages. Furthermore, we found that peroxiredoxin (Prx), an endogenous antioxidant, was identified as a novel damage-associated molecular patterns (DAMPs). Therefore, we examined the mechanisms that reduce damages from the innate immune responses after brain ischemia. We found that DAMPS were cleared by the infiltrating macrophages and transcriptional factors MAFB and class A scavenger receptor MSR1 are key factors of resolution by the macrophages. These findings indicate that targeting the innate immunity may become a novel approach for stroke treatment.
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