The elucidation of the mechanisms of subthalamic nucleus deep brain stimulation on higher micturition centre

• Project/Area Number: 26461306
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Chiba University
• Principal Investigator: Yamamoto Tatsuya 千葉大学, 大学院医学研究院, 助教 (50375755)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: パーキンソン病 / 視床下核脳深部刺激療法 / 高位排尿中枢 / 視床下核脳深部刺激療法(STN-DBS) / 下部尿路機能障害 / 神経活動 / 神経伝達物質 / 細胞外電位 / パーキンソン病モデルラット

Outline of Final Research Achievements

Although it is well known that the subthalamic nucleus deep brain stimulation (STN-DBS) dramatically improve motor complication, the effect of STN-DBS on lower urinary tract dysfunction remains to be elucidated. We examined the effect of STN-DBS on higher micturition centrre such as prefrontal cortex by recording extracellular potential and neurotransmitter using normal and Parkinson's disease model rat.
The extracellular potential of higer micturition centre was changed by STN-DBS. The levels of neurotransmitter such as catecholamine were also changed by STN-DBS. The effect of STN-DBS on extracellular potential and neurotransmitter in higher micturition centre differed significantly between normal and Parkinson's disease model rat. These findings suggested the STN-DBS might regulate the micturition reflex by changing the activity of higher micturition centre differently between normal and Parkinson's disease model rat.

Research Products

• [Journal Article] The Utility of Post-Void Residual Volume versus Sphincter Electromyography to Distinguish between Multiple System Atrophy and Parkinson's Disease. (2017)
  • Author(s): Yamamoto T, Asahina M, Yamanaka Y, Uchiyama T, Hirano S, Fuse M, Koga Y, Sakakibara R, Kuwabara S.
  • Journal Title: PLOS ONE Volume: - Issue: 1 Pages: e0169405-e0169405
  • DOI: 10.1371/journal.pone.0169405
  • Peer Reviewed / Open Access
• [Journal Article] The urinary symptoms and neurological disabilities are differentially correlated between multiple sclerosis and neuromyelitis optica. (2016)
  • Author(s): Yamamoto T, Mori M, Uzawa A, Uchiyama T, Sakakibara R, Yanagisawa M, Ohno S, Nomura F, Kuwabara S.
  • Journal Title: Clinical & Experimental Neuroimmunology Volume: 7 Issue: 1 Pages: 52-58
  • DOI: 10.1111/cen3.12279
  • Peer Reviewed
• [Journal Article] Urinary dysfunctions are more severe in the parkinsonian phenotype of multiple system atrophy. (2016)
  • Author(s): Yamamoto T, Asahina M, Yamanaka Y, Uchiyama T, Hirano S, Sugiyama A, Sakakibara R, Kuwabara S.
  • Journal Title: Movement Disorders Clinical Practice Volume: 3 Issue: 3 Pages: 275-281
  • DOI: 10.1002/mdc3.12289
  • Peer Reviewed
• [Journal Article] Urinary Dysfunction in Progressive Supranuclear Palsy Compared with Other Parkinsonian Disorders. (2016)
  • Author(s): Yamamoto T, Tateno F, Sakakibara R, Furukawa S, Asahina M, Uchiyama T, Hirano S, Yamanaka Y, Fuse M, Koga Y, Yanagisawa M, Kuwabara S.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0149278-e0149278
  • DOI: 10.1371/journal.pone.0149278
  • Peer Reviewed / Open Access
• [Journal Article] Urinary Dysfunctions Are More Severe in the Parkinsonian Phenotype of Multiple System Atrophy (2016)
  • Author(s): Yamamoto T, Tateno F, Sakakibara R, Furukawa S, Asahina M, Uchiyama T, Hirano S, Yamanaka Y, Fuse M, Koga Y, Yanagisawa M, Kuwabara S.
  • Journal Title: Moevement Disorders Clinical Practice Volume: in press
  • Peer Reviewed
• [Journal Article] Urinary symptoms and neurological disabilities are differentially correlated between multiple sclerosis and neuromyelitis optica (2016)
  • Author(s): Tatsuya Yamamoto,1 Masahiro Mori,1 Akiyuki Uzawa,1 Tomoyuki Uchiyama,1,2 Ryuji Sakakibara,3 Mitsuru Yanagisawa4 and Satoshi Kuwabara1
  • Journal Title: Clinical and Experimental Neuroimmunology Volume: 7 Pages: 52-58
  • Peer Reviewed
• [Journal Article] Subthalamic Nucleus Deep Brain Stimulation Modulate Catecholamine Levels with Significant Relations to Clinical Outcome after Surgery in Patients with Parkinson's Disease. (2015)
  • Author(s): Yamamoto T, Uchiyama T, Higuchi Y, Asahina M, Hirano S, Yamanaka Y, Kuwabara S.
  • Journal Title: PLoS One Volume: 10 Issue: 9 Pages: e0138462-e0138462
  • DOI: 10.1371/journal.pone.0138462
  • Peer Reviewed / Open Access
• [Journal Article] Metronidazole-induced encephalopathy with contrast enhancing lesions on MRI (2015)
  • Author(s): Furukawa S, Yamamoto T, Sugiyama A, Ohira K, Aotsuka Y, Koide K, Kojima K, Kuwabara S.
  • Journal Title: Journal of the neurological science Volume: 352 Issue: 1-2 Pages: 129-131
  • DOI: 10.1016/j.jns.2015.03.039
  • Peer Reviewed
• [Journal Article] The subthalamic activity and striatal monoamine are modulated by subthalamic stimulation. (2014)
  • Author(s): Yamamoto T, Uchiyama T, Sakakibara R, Taniguchi J, Kuwabara S.
  • Journal Title: Neuroscience Volume: 259 Pages: 43-52
  • DOI: 10.1016/j.neuroscience.2013.11.034
  • Peer Reviewed
• [Journal Article] Time-dependent changes and gender differences in urinary dysfunction in patients with multiple system atrophy. (2014)
  • Author(s): Yamamoto T, Sakakibara R, Uchiyama T, Yamaguchi C, Ohno S, Nomura F, Yanagisawa M, Hattori T, Kuwabara S.
  • Journal Title: Neurourology and Urodynamics Volume: 33 Issue: 5 Pages: 516-523
  • DOI: 10.1002/nau.22441
  • Peer Reviewed
• [Presentation] 神経因性膀胱におけるUDSの意義 (2016)
  • Author(s): 山本達也
  • Organizer: 第23回日本排尿機能学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-12-06
  • Invited
• [Presentation] 尿流動態機能検査（筋電図解析含む）による下部尿路機能の解析 (2016)
  • Author(s): 山本達也
  • Organizer: 第69回日本自律神経学会総会
  • Place of Presentation: 熊本県民交流館パレアホール
  • Year and Date: 2016-11-10
  • Invited
• [Presentation] メディカルスタッフレクチャー 20「排尿障害」 (2016)
  • Author(s): 山本達也
  • Organizer: 第34回日本神経治療学会総会
  • Place of Presentation: 米子市文化ホール
  • Year and Date: 2016-11-03
  • Invited
• [Presentation] Subthalamic nucleus deep brain stimulation modulate catecholamine levels with significant relations to clinical outcome after surgery in patients with Parkinson's disease. (2016)
  • Author(s): Yamamoto T, Uchiyama T, Higuchi Y, Asahina M, Hirano S, Yamanaka Y and Kuwabara S.
  • Organizer: The MDS 20th International Congress of Parkinson's Disease and
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2016-06-19
  • Int'l Joint Research
• [Presentation] EC-08（生涯教育）自律神経機能検査をやってみよう： この症候に出会ったらどうする？ 排尿障害・性機能障害に出会ったら (2016)
  • Author(s): 山本達也
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2016-05-18
  • Invited
• [Presentation] 多系統萎縮症患者における起立性低血圧と残尿量の関係-病型別の検討 (2015)
  • Author(s): 山本達也, 朝比奈正人, 内山智之, 平野成樹, 山中義崇, 杉山淳比古, 柳澤 充, 榊原隆次, 桑原 聡.
  • Organizer: 第33回日本神経治療学会
  • Place of Presentation: 名古屋国際会議場 （愛知県、名古屋市）
  • Year and Date: 2015-11-26
• [Presentation] 多系統萎縮症患者における起立性低血圧と残尿量の関係-病型別の検討 (2015)
  • Author(s): 山本達也, 朝比奈正人, 内山智之, 平野成樹, 山中義崇, 杉山淳比古, 柳澤 充, 榊原隆次, 桑原 聡.
  • Organizer: 第68回日本自律神経学会総会
  • Place of Presentation: ウインクあいち（愛知県、名古屋市）
  • Year and Date: 2015-10-28
• [Presentation] 進行性核上性麻痺の排尿障害の特徴―パーキンソン病・多系統萎縮症との比較 (2015)
  • Author(s): 山本達也, 朝比奈正人, 内山智之, 平野成樹, 山中義崇, 杉山淳比古, 柳澤 充, 榊原隆次, 桑原 聡.
  • Organizer: 第9回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 品川プリンスホテル （東京都、品川区）
  • Year and Date: 2015-10-15
• [Presentation] Receiver operating characteristic analysis of sphincter electromyography and post-void residuals for multiple system atrophy (2015)
  • Author(s): Yamamoto T, Asahina M, Uchiyama T, Hirano S, Yamanaka Y, Sugiyama A, Yanagisawa M, Sakakibara R, Kuwabara S
  • Organizer: The International Society for Autonomic Neuroscience (ISAN) 2015
  • Place of Presentation: Palazzo dei Congressi di Stresa (Stresa, Italy)
  • Year and Date: 2015-09-16
  • Int'l Joint Research
• [Presentation] 核上型・橋上型神経因性膀胱（大脳・脳幹疾患による神経因性膀胱） (2015)
  • Author(s): 山本達也, 朝比奈正人, 内山智之, 平野成樹, 山中義崇, 杉山淳比古, 柳澤 充, 榊原隆次, 桑原 聡.
  • Organizer: 第22回日本排尿機能学会
  • Place of Presentation: 京王プラザホテル （北海道、札幌市）
  • Year and Date: 2015-09-09
  • Invited
• [Presentation] Urinary dysfunction in progressive supranuclear palsy in comparison to Parkinson’s disease and multiple system atrophy (2015)
  • Author(s): Yamamoto T, Asahina M, Uchiyama T, Hirano S, Yamanaka Y, Sugiyama A, Yanagisawa M, Sakakibara R, Kuwabara S.
  • Organizer: 19th International Congress of Parkinson’s Disease and Movement
  • Place of Presentation: Manchester Grand Hyatt San Diego （San Diego, USA)
  • Year and Date: 2015-06-14
  • Int'l Joint Research
• [Presentation] 進行性核上性麻痺の排尿障害の特徴―パーキンソン病・多系統萎縮症との比較 (2015)
  • Author(s): 山本達也, 朝比奈正人, 内山智之, 平野成樹, 山中義崇, 杉山淳比古, 柳澤 充, 榊原隆次, 桑原 聡.
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ(新潟コンベンションセンター）（新潟県、新潟市）
  • Year and Date: 2015-05-20
• [Presentation] 多系統萎縮症における排尿症状の発症時期―病型別の検討 (2014)
  • Author(s): 山本達也, 朝比奈正人, 内山智之, 平野成樹, 山中義崇, 杉山淳比古, 柳澤 充, 榊原隆次, 桑原 聡.
  • Organizer: 第67回日本自律神経学会総会
  • Place of Presentation: ラフレさいたま（埼玉県さいたま市）
  • Year and Date: 2014-10-30 – 2014-10-31
• [Presentation] パーキンソン病DBS施行患者におけるPDQ-39の経時的変化-当院の現状 (2014)
  • Author(s): 山本達也, 内山智之, 樋口佳則, 平野成樹, 朝比奈正人, 山中義崇, 桑原聡
  • Organizer: 第8回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都ホテルオークラ(京都府京都市）
  • Year and Date: 2014-10-02 – 2014-10-04
• [Presentation] The time of the onset of urinary symptoms in multiple system atrophy. (2014)
  • Author(s): Yamamoto T, Asahina M, Uchiyama T, Hirano S, Yamanaka Y, Sugiyama A, Yanagisawa M, Sakakibara R, Kuwabara S.
  • Organizer: The 18th International Parkinson Disease and Movement Disorder Society
  • Place of Presentation: Stockholm(Sweden)
  • Year and Date: 2014-06-09 – 2014-06-12
• [Presentation] 多系統萎縮症における排尿症状の発症時期―病型別の検討. (2014)
  • Author(s): 山本達也, 朝比奈正人, 内山智之, 平野成樹, 山中義崇, 杉山淳比古, 柳澤 充, 榊原隆次, 桑原 聡.
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市）
  • Year and Date: 2014-05-21 – 2014-05-24
• [Book] 自律神経機能検査 第5版（日本自律神経学会） (2015)
  • Author(s): 山本達也、朝比奈正人、榊原隆次、桑原 聡
  • Total Pages: 478
  • Publisher: 株式会社文光堂･東京