The elucidation of the mechanisms of subthalamic nucleus deep brain stimulation on higher micturition centre
Project/Area Number |
26461306
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Chiba University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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Keywords | パーキンソン病 / 視床下核脳深部刺激療法 / 高位排尿中枢 / 視床下核脳深部刺激療法(STN-DBS) / 下部尿路機能障害 / 神経活動 / 神経伝達物質 / 細胞外電位 / パーキンソン病モデルラット |
Outline of Final Research Achievements |
Although it is well known that the subthalamic nucleus deep brain stimulation (STN-DBS) dramatically improve motor complication, the effect of STN-DBS on lower urinary tract dysfunction remains to be elucidated. We examined the effect of STN-DBS on higher micturition centrre such as prefrontal cortex by recording extracellular potential and neurotransmitter using normal and Parkinson's disease model rat. The extracellular potential of higer micturition centre was changed by STN-DBS. The levels of neurotransmitter such as catecholamine were also changed by STN-DBS. The effect of STN-DBS on extracellular potential and neurotransmitter in higher micturition centre differed significantly between normal and Parkinson's disease model rat. These findings suggested the STN-DBS might regulate the micturition reflex by changing the activity of higher micturition centre differently between normal and Parkinson's disease model rat.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Urinary Dysfunction in Progressive Supranuclear Palsy Compared with Other Parkinsonian Disorders.2016
Author(s)
Yamamoto T, Tateno F, Sakakibara R, Furukawa S, Asahina M, Uchiyama T, Hirano S, Yamanaka Y, Fuse M, Koga Y, Yanagisawa M, Kuwabara S.
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Journal Title
PLoS One
Volume: 11
Issue: 2
Pages: e0149278-e0149278
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Urinary Dysfunctions Are More Severe in the Parkinsonian Phenotype of Multiple System Atrophy2016
Author(s)
Yamamoto T, Tateno F, Sakakibara R, Furukawa S, Asahina M, Uchiyama T, Hirano S, Yamanaka Y, Fuse M, Koga Y, Yanagisawa M, Kuwabara S.
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Journal Title
Moevement Disorders Clinical Practice
Volume: in press
Related Report
Peer Reviewed
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[Presentation] 多系統萎縮症における排尿症状の発症時期―病型別の検討2014
Author(s)
山本達也, 朝比奈正人, 内山智之, 平野成樹, 山中義崇, 杉山淳比古, 柳澤 充, 榊原隆次, 桑原 聡.
Organizer
第67回日本自律神経学会総会
Place of Presentation
ラフレさいたま(埼玉県さいたま市)
Year and Date
2014-10-30 – 2014-10-31
Related Report
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