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Spreading of neuropathology and intrinsic functional neuronal network in movement disorders

Research Project

Project/Area Number 26461309
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKyoto University

Principal Investigator

Sawamoto Nobukatsu  京都大学, 医学研究科, 教授 (90397547)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsパーキンソン病 / 神経機能画像 / ネットワーク / ドパミン神経 / 線条体 / 中脳黒質 / 視床下核 / 認知症を伴うパーキンソン病 / 多系統萎縮症
Outline of Final Research Achievements

We investigated a link among damage to dopamine nerve terminals and cell bodies, abnormal intrinsic functional neuronal network and clinical symptoms in Parkinson disease. Early stage patients with less than 5 years of disease duration showed strong local correlation of neuronal activity within dopamine terminal lesioned area in the striatum, and degree of this local correlation was related to severity of bradykinesia. In contrast, in advanced stage patients with more than 5 years of disease duration, degree of dopamine cell body loss in the substantia nigra, but not of dopamine nerve terminal change in the striatum, correlated severity of bradykinesia. The present findings suggest that motor symptoms in Parkinson disease are associated with dopamine nerve terminal lesion in the striatum in the early stage while they are connected to dopamine cell body pathology in the substantia nigra in the advanced stage.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (29 results)

All 2017 2016 2015 2014

All Journal Article (18 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 18 results,  Open Access: 13 results,  Acknowledgement Compliant: 11 results) Presentation (11 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Convergence paralysis caused by a localized cerebral infarction affecting the white matter underlying the right frontal eye field2017

    • Author(s)
      Kinoshita H, Maki T, Hata M, Nakayama Y, Yamashita H, Sawamoto N, Ikeda A, Takahashi R
    • Journal Title

      Neurol Sci

      Volume: 375 Pages: 94-96

    • DOI

      10.1016/j.jns.2017.01.054

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway2017

    • Author(s)
      Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi, T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
    • Journal Title

      Human Brain Mapping

      Volume: 38 (4) Issue: 4 Pages: 1977-1991

    • DOI

      10.1002/hbm.23498

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Paraneoplastic Limbic Encephalitis in a Human Epidermal Growth Factor Receptor-2-positive Gastric Cancer Patient Treated with Trastuzumab-combined Chemotherapy: A Case Report and Literature Review2016

    • Author(s)
      Uneno Y, Yokoyama A, Nishikawa Y, Funakoshi T, Ozaki Y, Aoyama I, Yamaguchi D, Morita S, Mori Y, Kanai M, Kinoshita H, Inoue T, Sawamoto N, Matsumoto R, Matsumoto S, Muto M.
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 18 Pages: 2605-2609

    • DOI

      10.2169/internalmedicine.55.6917

    • NAID

      130005414847

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Altered striatal circuits underlie characteristic personality traits in Parkinson's disease.2016

    • Author(s)
      Ishii T, Sawamoto N, Tabu H, Kawashima H, Okada T, Togashi K, Takahashi R, Fukuyama H.
    • Journal Title

      J Neurol.

      Volume: 263 Issue: 9 Pages: 1828-39

    • DOI

      10.1007/s00415-016-8206-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Epileptic network of hypothalamic hamartoma: An EEG-fMRI study.2016

    • Author(s)
      Usami K, Matsumoto R, Sawamoto N, Murakami H, Inouchi M, Fumuro T, Shimotake A, Kato T, Mima T, Shirozu H, Masuda H, Fukuyama H, Takahashi R, Kameyama S, Ikeda A
    • Journal Title

      Epilepsy Res

      Volume: 125 Pages: 1-9

    • DOI

      10.1016/j.eplepsyres.2016.05.011

    • NAID

      120006305999

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Diagnostic utility of FDG-PET in neurolymphomatosis: report of five cases.2016

    • Author(s)
      Kinoshita H, Yamakado H, Kitano T, Kitamura A, Yamashita H, Miyamoto M, Hitomi T, Okada T, Nakamoto Y, Sawamoto N, Takaori-Kondo A, Takahashi R.
    • Journal Title

      J Neurol.

      Volume: 263 Issue: 9 Pages: 1719-26

    • DOI

      10.1007/s00415-016-8190-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Network specific change in white matter integrity in mesial temporal lobe epilepsy.2016

    • Author(s)
      Imamura, H., R. Matsumoto, S. Takaya, T. Nakagawa, A. Shimotake, T. Kikuchi, N. Sawamoto, T. Kunieda, N. Mikuni, S. Miyamoto, H. Fukuyama, R. Takahashi and A. Ikeda
    • Journal Title

      Epilepsy Research

      Volume: 120 Pages: 65-72

    • DOI

      10.1016/j.eplepsyres.2015.12.003

    • NAID

      120005749848

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stimulus-driven changes in the direction of neural priming during visual word recognition2016

    • Author(s)
      Pas, M., Nakamura, K., Sawamoto, N., Aso, T., Fukuyama, H.
    • Journal Title

      Neuroimage

      Volume: 125 Pages: 428-436

    • DOI

      10.1016/j.neuroimage.2015.10.063

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Color harmony represented by activity in the medial orbitofrontal cortex and amygdala.2015

    • Author(s)
      Ikeda T, Matsuyoshi D, Sawamoto N, Fukuyama H, Osaka N.
    • Journal Title

      Front Hum Neurosci.

      Volume: 9 Issue: 382 Pages: 382-382

    • DOI

      10.3389/fnhum.2015.00382

    • NAID

      120005947008

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional relevance of the precuneus in verbal politeness.2015

    • Author(s)
      Ashizuka A, Mima T, Sawamoto N, Aso T, Oishi N, Sugihara G, Kawada R, Takahashi H, Murai T, Fukuyama H.
    • Journal Title

      Neurosci Res.

      Volume: 91 Pages: 48-56

    • DOI

      10.1016/j.neures.2014.10.009

    • NAID

      120005593691

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Task-specific brain reorganization in motor recovery induced by a hybrid-rehabilitation combining training with brain stimulation after stroke.2015

    • Author(s)
      Koganemaru S, Sawamoto N, Aso T, Sagara A, Ikkaku T, Shimada K, Kanematsu M, Takahashi R, Domen K, Fukuyama H, Mima T.
    • Journal Title

      Neurosci Res.

      Volume: 92 Pages: 29-38

    • DOI

      10.1016/j.neures.2014.10.004

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Network hyperexcitability in a patient with partial reading epilepsy: Converging evidence from magnetoencephalography, diffusion tractography, and functional magnetic resonance imaging2015

    • Author(s)
      Fumuro T, Matsumoto R, Shimotake A, Matsuhashi M, Inouchi M, Urayama S, Sawamoto N, Fukuyama H, Takahashi R, Ikeda A
    • Journal Title

      Clinical Neurophysiology

      Volume: 126 (4) Issue: 4 Pages: 675-681

    • DOI

      10.1016/j.clinph.2014.07.033

    • NAID

      120005625620

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tactile priming modulates the activation of the fronto-parietal circuit during tactile angle match and non-match processing2014

    • Author(s)
      Jiajia Yang, Yinghua Yu, Akinori Kunita, Qiang Huang, Jinglong Wu, Nobukatsu Sawamoto, Hidenao Fukuyama
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 8 Pages: 926-926

    • DOI

      10.3389/fnhum.2014.00926

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Insular activation during reward anticipation reflects duration of illness in abstinent pathological gamblers.2014

    • Author(s)
      Tsurumi K, Kawada R, Yokoyama N, Sugihara G, Sawamoto N, Aso T, Fukuyama H, Murai T, Takahashi H.
    • Journal Title

      Front Psychol.

      Volume: 5 Pages: 1013-1013

    • DOI

      10.3389/fpsyg.2014.01013

    • NAID

      120005496639

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The contribution of cortical thickness and surface area to gray matter asymmetries in the healthy human brain2014

    • Author(s)
      Koelkebeck K, Miyata J, Kubota M, Kohl W, Son S, Fukuyama H, Sawamoto N, Takahashi H, Murai T.
    • Journal Title

      Hum Brain Mapp.

      Volume: 35 Issue: 12 Pages: 6011-22

    • DOI

      10.1002/hbm.22601

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training.2014

    • Author(s)
      Yoshida M, Origuchi M, S, Takatsuki A, Kan S, Aso T, Shiose T, Sawamoto S, Miyauchi S, Fukuyama H, Seiyama A.
    • Journal Title

      NeuroImage: Clin.

      Volume: 5 Pages: 161-168

    • DOI

      10.1016/j.nicl.2014.02.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation.2014

    • Author(s)
      Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S.
    • Journal Title

      Hum Brain Mapp

      Volume: 印刷中 Issue: 9 Pages: 74-85

    • DOI

      10.1002/hbm.22479

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Global association between cortical thinning and white matter integrity reduction in schizophrenia.2014

    • Author(s)
      Sasamoto, A., Miyata, J., Kubota, M., Hirao, K., Kawada, R., Fujimoto, S., Tanaka, Y., Hazama, M., Sugihara, G., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
    • Journal Title

      Schizophrenia Bulletin

      Volume: 40 Issue: 2 Pages: 420-427

    • DOI

      10.1093/schbul/sbt030

    • NAID

      120005619771

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Altered functional connectivity associated with striatal dopamine depletion in Parkinson disease2016

    • Author(s)
      Atsushi Shima, Nobukatsu Sawamoto, Rika Inano, Hayato Tabu, Tomohisa Okada, Kaori Togashi, Ryosuke Takahashi
    • Organizer
      Neuroscience 2016 Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relation of acute levodopa challenge and striatal dopamine transporter density in Parkinson’s disease2016

    • Author(s)
      月田 和人, 澤本 伸克, 御前 隆, 田中 寛大, 酒巻 春日, 山中 治郎, 和田 一孝, 古川 公嗣, 神辺 大輔, 新出 明代, 景山 卓, 末長 敏彦
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経メラニンMRI画像についての基礎的検討2015

    • Author(s)
      丸浜 伸一朗, 澤本 伸克, 辰己 新水, 岡田 知久, 富樫 かおり, 髙橋 良輔
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] くすぶり型自己免疫介在性脳炎の長期転帰:臨床・画像経過の検討2015

    • Author(s)
      松本 理器, 金澤 恭子, 十川 純平, 引網 亮太, 井上 岳司, 小林 勝哉, 下竹 昭寛, 澤本 伸克, 髙橋 良輔, 池田 昭夫
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 神経核内封入体病の生前診断における尿細胞診の有用性2015

    • Author(s)
      井上 穣, 齊田 浩二, 山下 博史, 辰己 新水, 澤本 伸克, 池田 昭夫, 髙橋 良輔
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] FUS遺伝子変異を伴う筋萎縮性側索硬化症の臨床像:若年発症例を含む4症例の検討2015

    • Author(s)
      引網 亮太, 端 祐一郎, 山門 穂高, 山下 博史, 澤本 伸克, 辻 輝之, 川本 未知, 幸原 伸夫, 井上 治久, 漆谷 真, 髙橋 良輔
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Altered connectivity within and between two different salience related networks in people with schizophrenia2015

    • Author(s)
      Jun Miyata, Nobukatsu Sawamoto, Yasuo Mori, Masanori Isobe, Shinichi Urayama, Toshihiko Aso, Hidenao Fukuyama, Toshiya Murai, Hidehiko Takahashi
    • Organizer
      15th International congress on schizophrenia research
    • Place of Presentation
      Colorado Springs, USA
    • Year and Date
      2015-03-28 – 2015-04-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 皮質―皮質間誘発電位を用いた言語の術中モニタリングへの応用2014

    • Author(s)
      國枝武治, 山尾幸広, 松本理器, 鈴木健吾, 荒川芳輝, 菊池隆幸, 稲田拓, 高橋由紀, 西田誠, 中江卓郎, 稲野理賀, 芝田純也, 澤本伸克, 三國信啓, 池田昭夫, 宮本享
    • Organizer
      日本脳神経外科学会第73回学術総会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 3-Tesla intraoperative MRI によるアップデートナビゲーションシステムと 今後の展望2014

    • Author(s)
      荒川芳輝, 岡田知久, 澤本伸克, 山尾幸広, 菊池隆幸, 國枝武治, 高木康志, 宮本享
    • Organizer
      日本脳神経外科学会第73回学術総会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] MRIを用いた術前後の運動機能と脳機能ネットワークの解明2014

    • Author(s)
      山尾 幸広, 澤本 伸克, 國枝 武治, 菊池 隆幸, 松本 理器, 池田 昭夫, 高橋 良輔, 福山 秀直, 宮本 享
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 自己ペース運動と外的ペース運動では 異なる皮質基底核回路が関わる2014

    • Author(s)
      小栗卓也, 澤本伸克, 椨勇人, 松川則之, 高橋良輔, 福山秀直
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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