Spreading of neuropathology and intrinsic functional neuronal network in movement disorders
Project/Area Number |
26461309
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | パーキンソン病 / 神経機能画像 / ネットワーク / ドパミン神経 / 線条体 / 中脳黒質 / 視床下核 / 認知症を伴うパーキンソン病 / 多系統萎縮症 |
Outline of Final Research Achievements |
We investigated a link among damage to dopamine nerve terminals and cell bodies, abnormal intrinsic functional neuronal network and clinical symptoms in Parkinson disease. Early stage patients with less than 5 years of disease duration showed strong local correlation of neuronal activity within dopamine terminal lesioned area in the striatum, and degree of this local correlation was related to severity of bradykinesia. In contrast, in advanced stage patients with more than 5 years of disease duration, degree of dopamine cell body loss in the substantia nigra, but not of dopamine nerve terminal change in the striatum, correlated severity of bradykinesia. The present findings suggest that motor symptoms in Parkinson disease are associated with dopamine nerve terminal lesion in the striatum in the early stage while they are connected to dopamine cell body pathology in the substantia nigra in the advanced stage.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway.2017
Author(s)
Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S.
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Journal Title
Hum Brain Mapp.
Volume: 38
Pages: 1977-1991
DOI
Related Report
Peer Reviewed
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[Journal Article] Paraneoplastic Limbic Encephalitis in a Human Epidermal Growth Factor Receptor-2-positive Gastric Cancer Patient Treated with Trastuzumab-combined Chemotherapy: A Case Report and Literature Review.2016
Author(s)
Uneno Y, Yokoyama A, Nishikawa Y, Funakoshi T, Ozaki Y, Aoyama I, Baba K, Yamaguchi D, Morita S, Mori Y, Kanai M, Kinoshita H, Inoue T, Sawamoto N, Matsumoto R, Matsumoto S, Muto M.
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Journal Title
Intern Med.
Volume: 55
Pages: 2605-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Epileptic network of hypothalamic hamartoma: An EEG-fMRI study.2016
Author(s)
Usami K, Matsumoto R, Sawamoto N, Murakami H, Inouchi M, Fumuro T, Shimotake A, Kato T, Mima T, Shirozu H, Masuda H, Fukuyama H, Takahashi R, Kameyama S, Ikeda A.
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Journal Title
Epilepsy Res.
Volume: 125
Pages: 1-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Diagnostic utility of FDG-PET in neurolymphomatosis: report of five cases.2016
Author(s)
Kinoshita H, Yamakado H, Kitano T, Kitamura A, Yamashita H, Miyamoto M, Hitomi T, Okada T, Nakamoto Y, Sawamoto N, Takaori-Kondo A, Takahashi R.
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Journal Title
J Neurol.
Volume: 263
Pages: 1719-26
DOI
Related Report
Peer Reviewed
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[Journal Article] Network specific change in white matter integrity in mesial temporal lobe epilepsy.2016
Author(s)
Imamura H, Matsumoto R, Takaya S, Nakagawa T, Shimotake A, Kikuchi T, Sawamoto N, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A.
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Journal Title
Epilepsy Res.
Volume: 120
Pages: 65-72
DOI
Related Report
Peer Reviewed
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[Journal Article] Task-specific brain reorganization in motor recovery induced by a hybrid-rehabilitation combining training with brain stimulation after stroke.2015
Author(s)
Koganemaru S, Sawamoto N, Aso T, Sagara A, Ikkaku T, Shimada K, Kanematsu M, Takahashi R, Domen K, Fukuyama H, Mima T.
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Journal Title
Neurosci Res.
Volume: 92
Pages: 29-38.
DOI
Related Report
Peer Reviewed
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[Journal Article] Network hyperexcitability in a patient with partial reading epilepsy: converging evidence from magnetoencephalography, diffusion tractography, and functional magnetic resonance imaging.2015
Author(s)
Fumuro T, Matsumoto R, Shimotake A, Matsuhashi M, Inouchi M, Urayama S, Sawamoto N, Fukuyama H, Takahashi R, Ikeda A.
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Journal Title
Clin Neurophysiol.
Volume: 126
Pages: 675-81.
DOI
Related Report
Peer Reviewed
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[Journal Article] fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training.2014
Author(s)
Yoshida M, Origuchi M, Urayama S, Takatsuki A, Kan S, Aso T, Shiose T, Sawamoto N, Miyauchi S, Fukuyama H, Seiyama A.
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Journal Title
Neuroimage Clin.
Volume: 5
Pages: 161-8.
DOI
Related Report
Peer Reviewed
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[Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation.2014
Author(s)
Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S.
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Journal Title
Hum Brain Mapp.
Volume: 35
Pages: 4345-61.
DOI
Related Report
Peer Reviewed
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[Journal Article] Global association between cortical thinning and white matter integrity reduction in schizophrenia.2014
Author(s)
Sasamoto A, Miyata J, Kubota M, Hirao K, Kawada R, Fujimoto S, Tanaka Y, Hazama M, Sugihara G, Sawamoto N, Fukuyama H, Takahashi H, Murai T.
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Journal Title
Schizophr Bull.
Volume: 40
Pages: 420-7.
DOI
Related Report
Peer Reviewed
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[Presentation] Relation of acute levodopa challenge and striatal dopamine transporter density in Parkinson’s disease2016
Author(s)
月田 和人, 澤本 伸克, 御前 隆, 田中 寛大, 酒巻 春日, 山中 治郎, 和田 一孝, 古川 公嗣, 神辺 大輔, 新出 明代, 景山 卓, 末長 敏彦
Organizer
第57回日本神経学会学術大会
Place of Presentation
神戸
Year and Date
2016-05-18 – 2016-05-21
Related Report
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[Presentation] FUS遺伝子変異を伴う筋萎縮性側索硬化症の臨床像:若年発症例を含む4症例の検討2015
Author(s)
引網 亮太, 端 祐一郎, 山門 穂高, 山下 博史, 澤本 伸克, 辻 輝之, 川本 未知, 幸原 伸夫, 井上 治久, 漆谷 真, 髙橋 良輔
Organizer
第56回日本神経学会学術大会
Place of Presentation
新潟
Year and Date
2015-05-20 – 2015-05-23
Related Report
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[Presentation] 皮質―皮質間誘発電位を用いた言語の術中モニタリングへの応用2014
Author(s)
國枝武治, 山尾幸広, 松本理器, 鈴木健吾, 荒川芳輝, 菊池隆幸, 稲田拓, 高橋由紀, 西田誠, 中江卓郎, 稲野理賀, 芝田純也, 澤本伸克, 三國信啓, 池田昭夫, 宮本享
Organizer
日本脳神経外科学会第73回学術総会
Place of Presentation
東京
Year and Date
2014-10-09 – 2014-10-11
Related Report
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