Tracking of non-motor symptoms and functional brain imaging in early, untreated Parkinson's disease.
| Project/Area Number | 26461311 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kochi University |
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Principal Investigator |
Yasushi Osaki 高知大学, 教育研究部医療学系臨床医学部門, 講師 (20294829)
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| Co-Investigator(Kenkyū-buntansha) |
森田 ゆかり 高知大学, 教育研究部医療学系臨床医学部門, 助教 (10363293)
古谷 博和 高知大学, 教育研究部医療学系臨床医学部門, 教授 (60253415)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed(Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost : ¥3,700,000、Indirect Cost : ¥1,110,000)
Fiscal Year 2017 : ¥1,170,000 (Direct Cost : ¥900,000、Indirect Cost : ¥270,000)
Fiscal Year 2016 : ¥1,300,000 (Direct Cost : ¥1,000,000、Indirect Cost : ¥300,000)
Fiscal Year 2015 : ¥1,170,000 (Direct Cost : ¥900,000、Indirect Cost : ¥270,000)
Fiscal Year 2014 : ¥1,170,000 (Direct Cost : ¥900,000、Indirect Cost : ¥270,000)
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| Keywords | Parkinson's disease / motor complications / non-motor symptom / パーキンソン病 / 運動症状 / 非運動症状 / 運動合併症 / ニューロトランスミッター / ドパミントランスポーターSPECT / MRI拡散テンソル |
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| Outline of Final Research Achievements |
We prospectively tracked for 18 months motor, non-motor symptoms and motor complications in 52 patients with early, untreated Parkinson's disease. 27 patients had prodromal non-motor features. Although 3 patients showed bilateral onset, 49 patients showed unilateral onset. 40 patients were introduced medical treatment, whereas 12 patients were still untreated. 31 among the 49 patients presented unilateral onset, the symptoms progressed to bilteral features 15 months after the motor onset. Around the time, 27 patients had the first non-motor symptom after the motor onset.
In approximately 40% of the patients, the diaease started outseide the nigrostriatal pathway. In most patients, the disease started from onse side and thereafter it progresses to the other side. Around the time, they had the first non-motor symptom, namely, the disease progressed to the other neurotransmitter projection system(s), like cholinergic, seroninergic, noradrenergic or the others.
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Report
(5results)
Research Products
(25results)
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[Journal Article] Comparison of MRI and 123I-FP-CIT SPECT for the evaluation of MSA-P clinical severity2018
Author(s)
Nishimori M, Murata Y, Iwasa H, Miyatake K, Todokoro M, Kohsaki S, Nogami M, Hamada N, Ninomiya H, Osaki Y, Furuya Y, Yamagami T.
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Journal Title
Biomedical Reports
Volume : 8
Pages : 523-528
DOI
Related Report
Peer Reviewed
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[Journal Article] Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication.2016
Author(s)
Takamura S, Ikeda A, Nishioka K, Furuya H, Tashiro M, Matsushima T, Li Y, Yoshino H, Funayama M, Morinobu S, Hattori N.
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Journal Title
Parkinsonism Relat Disord.
Volume : S1353-8020
Pages : 30028-1
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Variants associated with Gaucher disease in multiple system atrophy.2015
Author(s)
Mitsui J, Matsukawa T, Sasaki H, Yabe I, Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Tsuji S, et al.
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Journal Title
Ann Clin Transl Neurol.
Volume : 2
Pages : 417-426
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Molecular epidemiology and clinical spectrum of hereditary spastic paraplegia in the Japanese population based on comprehensive mutational analyses.2014
Author(s)
Ishiura H, Takahashi Y, Hayashi T, Saito K, Furuya H, Watanabe M, Murata M, Suzuki M, Sugiura A, Sawai S, Shibuya K, Ueda N, Ichikawa Y, Kanazawa I, Goto J and Tsuji S
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Journal Title
J Hum Genet
Volume : 59
Pages : 163-172
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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