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Tracking of non-motor symptoms and functional brain imaging in early, untreated Parkinson's disease.

Research Project

Project/Area Number 26461311
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKochi University

Principal Investigator

Yasushi Osaki  高知大学, 教育研究部医療学系臨床医学部門, 講師 (20294829)

Co-Investigator(Kenkyū-buntansha) 森田 ゆかり  高知大学, 教育研究部医療学系臨床医学部門, 助教 (10363293)
古谷 博和  高知大学, 教育研究部医療学系臨床医学部門, 教授 (60253415)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsParkinson's disease / motor complications / non-motor symptom / パーキンソン病 / 運動症状 / 非運動症状 / 運動合併症 / ニューロトランスミッター / ドパミントランスポーターSPECT / MRI拡散テンソル
Outline of Final Research Achievements

We prospectively tracked for 18 months motor, non-motor symptoms and motor complications in 52 patients with early, untreated Parkinson's disease. 27 patients had prodromal non-motor features. Although 3 patients showed bilateral onset, 49 patients showed unilateral onset. 40 patients were introduced medical treatment, whereas 12 patients were still untreated. 31 among the 49 patients presented unilateral onset, the symptoms progressed to bilteral features 15 months after the motor onset. Around the time, 27 patients had the first non-motor symptom after the motor onset.
In approximately 40% of the patients, the diaease started outseide the nigrostriatal pathway. In most patients, the disease started from onse side and thereafter it progresses to the other side. Around the time, they had the first non-motor symptom, namely, the disease progressed to the other neurotransmitter projection system(s), like cholinergic, seroninergic, noradrenergic or the others.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2018 2017 2016 2015 2014 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (16 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Journal Article] Comparison of MRI and 123I-FP-CIT SPECT for the evaluation of MSA-P clinical severity2018

    • Author(s)
      Nishimori M, Murata Y, Iwasa H, Miyatake K, Todokoro M, Kohsaki S, Nogami M, Hamada N, Ninomiya H, Osaki Y, Furuya Y, Yamagami T.
    • Journal Title

      Biomedical Reports

      Volume: 8 Pages: 523-528

    • DOI

      10.3892/br.2018.1086

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Freezing of gait is an early clinical feature of progressive supranuclear palsy2017

    • Author(s)
      Osaki Y, Morita Y, Miyamoto Y, Furuta K, Furuya H.
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: in press Issue: 3 Pages: 86-90

    • DOI

      10.1111/ncn3.12122

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication.2016

    • Author(s)
      Takamura S, Ikeda A, Nishioka K, Furuya H, Tashiro M, Matsushima T, Li Y, Yoshino H, Funayama M, Morinobu S, Hattori N.
    • Journal Title

      Parkinsonism Relat Disord.

      Volume: S1353-8020 Pages: 30028-1

    • DOI

      10.1016/j.parkreldis.2016.01.028

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between tongue thickness and tongue pressure in neuromuscular disorders2016

    • Author(s)
      Umemoto G; Furuya H; Arahata H; Sugahara M; Sakai M; Tsuboi Y
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: 4 Issue: 4 Pages: 142-145

    • DOI

      10.1111/ncn3.12058

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 高齢で診断されたミトコンドリア病の1例2015

    • Author(s)
      杉浦健太、高橋有紗、久保亨、谷岡克敏、森田ゆかり、大崎康史、山崎直仁、古谷博和、北岡裕章
    • Journal Title

      日本内科学会雑誌

      Volume: 104 Pages: 2589-2593

    • NAID

      130005433345

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Variants associated with Gaucher disease in multiple system atrophy2015

    • Author(s)
      Mitsui J, Matsukawa T, Sasaki H, Yabe I, Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Tsuji S, et al.
    • Journal Title

      Ann Clin Transl Neurol.

      Volume: 2 Issue: 4 Pages: 417

    • DOI

      10.1002/acn3.185

    • URL

      https://localhost/en/publications/c946bad2-a238-4d0e-a396-6d33b3922ab7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] パーキンソン病講座 痛みに対するアンケート調査2015

    • Author(s)
      森田ゆかり
    • Journal Title

      難病と在宅ケア

      Volume: 20 Pages: 41-43

    • Related Report
      2014 Research-status Report
  • [Journal Article] Molecular epidemiology and clinical spectrum of hereditary spastic paraplegia in the Japanese population based on comprehensive mutational analyses2014

    • Author(s)
      Ishiura H, Takahashi Y, Hayashi T, Saito K, Furuya H, Watanabe M, Murata M, Suzuki M, Sugiura A, Sawai S, Shibuya K, Ueda N, Ichikawa Y, Kanazawa I, Goto J and Tsuji S
    • Journal Title

      J Hum Genet

      Volume: 59 Issue: 3 Pages: 163

    • DOI

      10.1038/jhg.2013.139

    • NAID

      40020021308

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Freezing of gait is an early clinical feature of progressive supranuclear palsy2017

    • Author(s)
      Osaki Y, Morita Y, Miyamoto Y, Furushima T, Furuta K, Furuya H.
    • Organizer
      21st International meeting of Parkinson's disease and Movement Disorders
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical significance and usefulness of palmomental reflex.2017

    • Author(s)
      Furushima T, Miyamoto Y, Morita Y, Furuta K, Osaki Y, Fujii N, Furuya H.
    • Organizer
      The XXIIIrd Worlo Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cerebrospinal fluid pH value is low in Multiple System Atrophy2017

    • Author(s)
      Osaki Y, Motita Y, Moyamoto Y, Furushima T, Furuta K, Furuya H.
    • Organizer
      The XXIIIrd Worlo Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Disease progression in Parkinson's disease.2017

    • Author(s)
      Osaki Y, Morita Y, Miyamoto Y, Furushima T, Furuta K, Furuya H.
    • Organizer
      The XXIIIrd Worlo Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 未治療パーキンソン病患者の病態の進展2017

    • Author(s)
      大崎康史、森田ゆかり、宮本由賀、古島朋美、古田興之介、古谷博和
    • Organizer
      第11回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2017 Annual Research Report
  • [Presentation] 病初期にすくみ足を呈する症例の検討2016

    • Author(s)
      大崎康史、森田ゆかり、宮本由賀、古島朋美、古田興之介、古谷博和
    • Organizer
      第34回日本神経治療学会総会
    • Place of Presentation
      米子コンベンションセンターBIG SHIP 米子市文化ホール(鳥取県米子市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 進行性核上性麻痺と大脳皮質基底核変性症で見られる垂直性核上性注視麻痺2016

    • Author(s)
      大崎康史、森田ゆかり、古島朋美、宮本由賀、古田興之介、古谷博和
    • Organizer
      第10回パーキンソン病・運動異常疾患コングレス
    • Place of Presentation
      京都ホテルオークラ(京都府京都市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Pseudobulbar palsy as an early feature in movement disorder clinic2016

    • Author(s)
      Osaki Y, Morita Y, Miyamoto Y, Furuta K, Furuya H.
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(神戸国際会議場.神戸国際展示場)神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Presentation] Symmetric parkinsonism as an early feature in movement disorder clinic2016

    • Author(s)
      Morita Y, Osaki Y, Miyamoto Y, Furuta K, Furuya H.
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(神戸国際会議場.神戸国際展示場)神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 進行性核上性麻痺の初期症状に関する検討2015

    • Author(s)
      大崎康史、森田ゆかり、宮本由賀、古谷博和
    • Organizer
      第9回パーキンソン病・運動異常症コングレス
    • Place of Presentation
      品川プリンスホテル(東京)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Research-status Report
  • [Presentation] Features preceding the clinical criteria for possible cortico-basal degeneration.2015

    • Author(s)
      Osaki Y, Morita Y, Miyamoto Y, Furuya H.
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Early clinical features of progressive supranuclear palsy2015

    • Author(s)
      Morita Y, Osaki Y, Miyamoto Y, Furuya H.
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] むずむず脚症候群が先行した認知症を伴うパーキンソン病の一剖検例2014

    • Author(s)
      大崎康史
    • Organizer
      第97回日本神経学会中国・四国地方会
    • Place of Presentation
      広島市 広島国際会議場
    • Year and Date
      2014-12-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 長期間のラスムッセン脳炎にTDP-43 proteinopathyによる筋萎縮性側索硬化症を合併した一例2014

    • Author(s)
      森田ゆかり
    • Organizer
      第96回日本神経学会中国・四国地方会
    • Place of Presentation
      岡山市 岡山コンベンションセンター
    • Year and Date
      2014-06-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 新規発症パーキンソン病患者の検討2014

    • Author(s)
      森田ゆかり
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市 福岡国際会議場
    • Year and Date
      2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 進行性核上性麻痺の臨床亜型2014

    • Author(s)
      大崎康史
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市 福岡国際会議場
    • Year and Date
      2014-05-21
    • Related Report
      2014 Research-status Report
  • [Remarks] 高知大学医学部老年病・循環器・神経内科学講座 神経内科部門

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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