|Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|Outline of Final Research Achievements
On embryonic day (E) 18, a frozen prove was placed on the frontal scalp of a Sprague-Dawley rat embryo through the uterus wall to produce multiple (one or two) freeze lesions on each hemisphere. FCD rat models were divided to group A (one lesion on the left), group B (two lesions on the left) and group C (one lesion on the each frontal areas). All rats were performed EEG monitoring with electrical stimulation onto the scalp electrodes from postnatalday (P) 1 to P7. The number of animals of group C showing myoclonic seizure was significantly more than the other groups on P1, however there was no significance between all groups through the stimulations. Immunoreactivities for N-methyl-D-aspertate receptors and glutamate transporters in FCD lesions were significantly enhanced compared to controls.