The association between several biomarkers and cognitive function in a community-dwelling populations aged 80 years and over.

• Project/Area Number: 26461313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: University of the Ryukyus
• Principal Investigator: Tokashiki Takashi 琉球大学, 医学部, 非常勤講師 (10336365)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 地域在住高齢者 / 認知機能 / 血管内皮前駆細胞 / ω-3脂肪酸 / 脳萎縮 / 食生活 / 野菜 / 脂肪酸分画 / 血管危険因子 / 地域住民高齢者

Outline of Final Research Achievements

The aims of this study are to evaluate the correlation between the count of vascular endothelial precursor cells, the amount of ω-3 fatty acids, the feature of brain image and cognitive function in a community-dwelling population aged 80 years and over. We carried out physical measurement (including 3m Up and Go test, ABI and PWV), blood test, survey of actual life situation, cognitive function test and brain magnetic resonance imaging for 161 Okinawan elderly participants. In blood test, we counted vascular endothelial precursor cells by using flow cytometry. In addition, we measured vascular function by various devices.

Research Products

• [Journal Article] Risk Factors Associated with Cortical Thickness and White Matter Hyperintensities in Dementia Free Okinawan Elderly. (2018)
  • Author(s): Silbert LC, Lahna D, Promjunyakul NO, Boespflug E, Ohya Y, Higashiuesato Y, Nishihira J, Katsumata Y, Tokashiki T, Dodge HH.
  • Journal Title: J Alzheimers Dis. Volume: 63 Issue: 1 Pages: 365-372
  • DOI: 10.3233/jad-171153
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between Serum Omega-3 Fatty Acid Levels and Cognitive Functions among Community-Dwelling Octogenarians in Okinawa, Japan: The KOCOA Study. (2016)
  • Author(s): Nishihira J, Tokashiki T, Higashiuesato Y, Willcox DC, Mattek N, Shinto L, Ohya Y, Dodge HH.
  • Journal Title: J Alzheimers Dis. Volume: 51 Issue: 3 Pages: 857-866
  • DOI: 10.3233/jad-150910
• [Presentation] 80歳以上の高齢者における歩行機能と認知機能の相関について (2016)
  • Author(s): 波平 幸裕, 渡嘉敷 崇, 西平淳子. 石田 明夫, 東上里 康司, 大屋 祐輔, Dodge Hiroko
  • Organizer: AAJ2016(Alzheimer Academy Japan 2016)
  • Place of Presentation: TKPガーデンシティ福岡県、福岡市
• [Presentation] Lower Ankle Brachial Index is associated with future decline of cognitive function in a community – dwelling population aged 80 years and over in Okinawa, Japan: the KOCOA project. (2015)
  • Author(s): Takashi Tokashiki, Akio Ishida, Yukihiro Namihira, Jyunko Nishihira, Yasushi Higashiuesato, Yusuke Ohya, Hiroko H Dodge
  • Organizer: GSA 68th Annual Scientific Meeting (Symposium)
  • Place of Presentation: オーランド（フロリダ州 米国）
  • Year and Date: 2015-11-18
  • Int'l Joint Research / Invited
• [Presentation] 地域在住高齢者の血清BDNFと脳萎縮、認知機能との関連－the KOCOA project－ (2015)
  • Author(s): 波平 幸裕，渡嘉敷 崇，西平淳子，東上里 康司，大屋 祐輔， Dodge Hiroko
  • Organizer: 第34回日本認知症学会
  • Place of Presentation: リンクステーションホール青森（青森 青森市）
  • Year and Date: 2015-10-02
• [Presentation] Ankle-brachial index低値は認知機能低下の 予測因子として有用である－the KOCOA project－ (2015)
  • Author(s): 波平 幸裕，渡嘉敷 崇，石田 明夫，東上里 康司，大屋 祐輔， Dodge Hiroko
  • Organizer: Vas-cog japan 2015
  • Place of Presentation: 東京ファッションタウン（東京 江東区）
  • Year and Date: 2015-09-17
• [Presentation] Associations between plasma omega-3 fatty acid levels and the MMSE scores among community-dwelling older adults in Okinawa, Japan. (2014)
  • Author(s): J. Nishihira, Takashi Tokashiki, Y. Higashiuesato, Y. Ohya, H H Dodge.
  • Organizer: American Neurological Association 2014 Annual meeting
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2014-10-12 – 2014-10-14
• [Presentation] Lower Ankle-Brachial Index is associated with future decline of cognitive function in a community-dwelling population aged 80 years and over. (2014)
  • Author(s): Takashi Tokashiki, A. Ishida, J. Nishihira, Y. Higashiuesato, Y. Ohya
  • Organizer: Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
  • Place of Presentation: Athens, Greece
  • Year and Date: 2014-06-13 – 2014-06-16
• [Presentation] 80歳以上高齢者におけるω-3系多価不飽和脂肪酸(PUFA)とMMSEとの関係性 (2014)
  • Author(s): 西平 淳子、渡嘉敷 崇、東上里 康司、大屋 祐輔．
  • Organizer: 第55回日本神経学会総会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-05-21 – 2014-05-24