| Project/Area Number |
26461314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Hoshi Akihiko 福島県立医科大学, 医学部, 講師 (80381383)
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| Research Collaborator |
KAKITA Akiyoshi
TADA Mari
TSUNODA Ayako
UGAWA Yoshikazu
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アクアポリン / 神経変性疾患 / アストロサイト |
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| Outline of Final Research Achievements |
We have conducted immunohistochemical analysis whether aquaporin (AQP), GLT-1, and Kir4.1 are associated with the pathogenesis of Alzheimer's disease, Parkinson's disease, and multiple system atrophy utilizing human brains affected by those disorders.
We have found that altered expressions of AQP, GLT-1, and Kir4.1 were observed in the brains, in particular, in the each area to be neuropathologically accented. These findings suggest disruption of water/glutamate/potassium homeostasis in the brain of neurodegenerative disorders, and it seems to contribute to the processes of neurodegeneration.
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