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Is water channel protein aquaporin involved in the pathogenesis of neurodegenerative disorders?

Research Project

Project/Area Number 26461314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionFukushima Medical University

Principal Investigator

Hoshi Akihiko  福島県立医科大学, 医学部, 講師 (80381383)

Research Collaborator KAKITA Akiyoshi  
TADA Mari  
TSUNODA Ayako  
UGAWA Yoshikazu  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsアクアポリン / 神経変性疾患 / アストロサイト
Outline of Final Research Achievements

We have conducted immunohistochemical analysis whether aquaporin (AQP), GLT-1, and Kir4.1 are associated with the pathogenesis of Alzheimer's disease, Parkinson's disease, and multiple system atrophy utilizing human brains affected by those disorders.
We have found that altered expressions of AQP, GLT-1, and Kir4.1 were observed in the brains, in particular, in the each area to be neuropathologically accented. These findings suggest disruption of water/glutamate/potassium homeostasis in the brain of neurodegenerative disorders, and it seems to contribute to the processes of neurodegeneration.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2018 2016 2015 2014

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 2 results,  Open Access: 3 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Altered expression of glutamate transporter-1 and water channel protein aquaporin-4 in human temporal cortex with Alzheimer’s disease2018

    • Author(s)
      A. Hoshi, A.Tsunoda, T. Yamamoto, M. Tada, A. Kakita, Y. Ugawa
    • Journal Title

      Neuropthology and applied Neurobiology

      Volume: 印刷中 Issue: 6 Pages: 628-638

    • DOI

      10.1111/nan.12475

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased neuronal and astroglial aquaporin-1 immunoreactivity in rat striatum by chemical preconditioning with 3-nitropropionic acid2016

    • Author(s)
      Akihiko Hoshi, Ayako Tsunoda, Teiji Yamamoto, Mari Tada, Akiyoshi Kakita, Yoshikazu Ugawa
    • Journal Title

      Neurosci Letters

      Volume: 626 Pages: 48-53

    • DOI

      10.1016/j.neulet.2016.05.021

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression of aquaporin 1 and aquaporin 4 in the temporal neocortex of patients with Parkinson's disease.2016

    • Author(s)
      Hoshi A, Tsunoda A, Tada M, Nishizawa M, Ugawa Y, Kakita A.
    • Journal Title

      Brain Pathol.

      Volume: - Issue: 2 Pages: 160-168

    • DOI

      10.1111/bpa.12369

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Valosin-containing protein-related amyotrophic lateral sclerosis in Japan2016

    • Author(s)
      Segawa M, Hoshi A, Ugawa Y
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 56 Issue: 4 Pages: 287-288

    • DOI

      10.5692/clinicalneurol.cn-000868

    • NAID

      130005149744

    • ISSN
      0009-918X, 1882-0654
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hemichorea-Hemiballism in a Patient with Temporal-Parietal Lobe Infarction Appearing After Reperfusion by Recombinant Tissue Plasminogen Activator2015

    • Author(s)
      Murakami T, Wada T, Sasaki I, Yoshida K, Segawa M, Kadowaki S, Yoshihara A, Kobayashi S, Hoshi A, Sugiura Y, Ugawa Y
    • Journal Title

      Move Disor Clinic Prac

      Volume: 2 Issue: 4 Pages: 426

    • DOI

      10.1002/mdc3.12198

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A patient with familial amyotrophic lateral sclerosis associated with a new valosin-containing protein (<i>VCP</i>) gene mutation2015

    • Author(s)
      Segawa M, Hoshi A, Naruse H, Kuroda M, Bujo H, Ugawa Y
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 55 Issue: 12 Pages: 914-920

    • DOI

      10.5692/clinicalneurol.cn-000765

    • NAID

      130005116934

    • ISSN
      0009-918X, 1882-0654
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] アクアポリンと神経・筋疾患(視神経脊髄炎以外)2015

    • Author(s)
      星明彦、角田綾子、宇川義一
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 80-82

    • Related Report
      2014 Research-status Report
  • [Journal Article] Cerebral amyloid angiopathy-related leukoencephalopathy: Successful steroid therapy treatment for neurological deficits and subcortical white matter lesions partly involving the cortical gray matter.2014

    • Author(s)
      Takenobu Murakami, Julia Morimoto, Akihiko Hoshi, et al.
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: 2 Issue: 4 Pages: 119-121

    • DOI

      10.1111/ncn3.101

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Immunohistochemical analysis of glutamate transporter-1 and water channel protein aquaporin-4 in human brain with Alzheimer’s disease2016

    • Author(s)
      Akihiko Hoshi, Saeri Saitou, Mari Tada, Akiyoshi Kakita, Yoshikazu Ugawa
    • Organizer
      第21回グリア研究会
    • Place of Presentation
      大阪
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 多系統萎縮症におけるアストロサイト特異的タンパク質の解析2015

    • Author(s)
      星明彦、角田綾子、宇川義一、西澤正豊、他田真理、柿田明美
    • Organizer
      第27回日本脳循環代謝学会総会
    • Place of Presentation
      富山
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 多系統萎縮症剖検脳におけるアストロサイトの病理学的解析2015

    • Author(s)
      星明彦、角田綾子、宇川義一、西澤正豊、他田真理、柿田明美
    • Organizer
      第56回日本神経病理学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Immunohistochemical analysis of water channel protein aquaporin and glutamate transporter GLT-1 expression in Alzheimer’s disease2015

    • Author(s)
      Akihiko Hoshi, Ayako Tsunoda, Mari Tada, Yoshikazu Ugawa, Masatoyo Nishizawa, Akiyoshi Kakita
    • Organizer
      The 13th International Conference on Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      フランス(ニース)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] アルツハイマー病脳におけるアクアポリンとグルタミン酸トランスポーターGLT-1の組織学的解析2014

    • Author(s)
      星明彦、角田綾子、宇川義一、西澤正豊、他田真理、高橋均、柿田明美
    • Organizer
      第55回日本神経病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 神経変性疾患におけるアクアポリンと内向き整流性カリウムチャネル4.1の解析2014

    • Author(s)
      星明彦、角田綾子、宇川義一、西澤正豊、他田真理、高橋均、柿田明美
    • Organizer
      第55回日本神経学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-22
    • Related Report
      2014 Research-status Report
  • [Book] Annual Review神経2018.2018

    • Author(s)
      星明彦
    • Total Pages
      333
    • Publisher
      中外医学社
    • ISBN
      9784498328068
    • Related Report
      2017 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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