Calcium-signaling abnormality of polyglutamine diseases

Research Project

Project/Area Number	26461315
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Neurology
Research Institution	Yokohama City University
Principal Investigator	KOYANO Shigeru 横浜市立大学, 医学部, 准教授 (50315818)
Co-Investigator(Kenkyū-buntansha)	田中章景横浜市立大学, 医学研究科, 教授 (30378012) 多田美紀子横浜市立大学, 附属病院, 助教 (30722467)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	ポリグルタミン病 / カルシウムシグナリング / カルシウムチャネル
Outline of Final Research Achievements	We examined association of polyglutamine disease and the calcium-signaling abnormality. Polyglutamine diseases are chronic, progressive neurodegenerative diseases caused by expansion of a glutamine tract in widely expressed genes and a heterogeneous group of dominantly inherited neurodegenerative disorders affecting the cerebellum and its associated pathways. These cause proteins are associated with cell death by calcium-signaling abnormality. We determined the possibility that a CACNA1A calcium channel in the polyglutamine disease was associated with abnormal cause protein formation of polyglutamine disease and identified a calcium channel subtype binding to cause protein. We confirmed the distribution of the calcium channel subtype expressions showed possibility reflecting a lesion of each polyglutamine disease and showed resistibility and vulnerability for the neurodegeneration.

Report

(4 results)

2016 Annual Research Report Final Research Report ( PDF )
2015 Research-status Report
2014 Research-status Report

Research Products
(1 results)

All Presentation (1 results)

[Presentation] 多系統萎縮症と尿酸との関連（病型別の検討）2016
- Author(s)
  児矢野繁、上田直久，東山雄一，上木英人，岸田日帯，木村活生，齋藤麻美，中江啓晴，釘本千春，土井宏，田中章景
- Organizer
  第57回神経学会総会
- Place of Presentation
  神戸コンベンションセンター神戸国際会議場（兵庫県）
- Year and Date
  2016-05-18
- Related Report
  2016 Annual Research Report