Utility of direct oral anticoagulant in the treatment of acute phase cerebral embolism

• Project/Area Number: 26461318
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Osaka City University
• Principal Investigator: Itoh Yoshiaki 大阪市立大学, 大学院医学研究科, 教授 (90265786)
• Co-Investigator(Kenkyū-buntansha): 大木 宏一 慶應義塾大学, 医学部(信濃町), 講師 (10348633) ; 畝川 美悠紀 慶應義塾大学, 医学部(信濃町), 特任講師 (10548481) ; 安部 貴人 慶應義塾大学, 医学部(信濃町), 講師 (30365233) ; 山田 哲 慶應義塾大学, 医学部(信濃町), 講師(非常勤) (80445296)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 心原性脳塞栓症 / 灌流圧 / マイクロスフェア / 境界領域梗塞 / 分水嶺梗塞 / perfusion pressure / microsphere / watershed infarction / 脳塞栓症 / 動脈原性塞栓症

Outline of Final Research Achievements

The current in vivo study demonstrated that Direct Oral AntiCoagulant (DOAC), clinically used for prevention of cardioembolism from nonvalvular atrial fibrillation, is effective in accelerating recirculation and in reducing the size of cerebral infarction. Clinically cases treated with DOACs not only have less cerebral infarction but also smaller size and lighter sequels. The current data proved the pathophysiology.

Research Products

• [Journal Article] Cerebral blood flow abnormality in clinically diagnosed Alzheimer's disease patients with or without amyloid β accumulation on positron emission tomography (2017)
  • Author(s): Mino, Toshikazu Saito, Haruna Takeuchi, Jun Ito, Kazuhiro Takeda, Akitoshi Ataka, Suzuka Shiomi, Susumu Wada, Yasuhiro Watanabe, Yasuyoshi Itoh, Yoshiaki
  • Journal Title: Neurology and Clinical Neuroscience Volume: 5 Issue: 2 Pages: 55-59
  • DOI: 10.1111/ncn3.12107
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Diameter of fluorescent microspheres injected into the internal carotid artery determines their distribution throughout the cortical watershed area in mice (2017)
  • Author(s): Naoki Tsukada, Masahiro Katsumata, Koichi Oki, Takato Abe, Shinichi Takahashi, Yoshiaki Itoh, Norihiro Suzuki
  • Journal Title: Stroke Volume: -
  • Peer Reviewed
• [Journal Article] Effects of Surgery and Antiplatelet Therapy in 10-year follow-up from the Registry Study of Research Committee on Moyamoya Disease in Japan (2016)
  • Author(s): Yamada S, Oki K, Itoh Y, Kuroda S, Houkin K, Tominaga T, Miyamoto S, Hashimoto N, Suzuki N
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 25 Issue: 2 Pages: 340-349
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.10.003
  • Peer Reviewed
• [Journal Article] Reduction of Small Fibers of Thoracic Ventral Roots and Neurons of Intermediolateral Nucleus in Parkinson Disease and Dementia with Lewy Bodies (2016)
  • Author(s): Hatsuta, H. Takao, M. Nakano, Y. Nogami, A. Uchino, A. Sumikura, H. Kanemaru, K. Arai, T. Itoh, Y. Murayama, S.
  • Journal Title: J Parkinsons Dis Volume: 6 Issue: 2 Pages: 325-34
  • DOI: 10.3233/jpd-150773
  • Peer Reviewed
• [Journal Article] A male case with beta-propeller protein-associated neurodegeneration (BPAN) with somatic mosaic mutation in WDR45 (2016)
  • Author(s): Jun Takeuchi, Kazuhiro Ito, Akitoshi Takeda, Hirotomo Saitsu, Naomichi Matsumoto, Yoshiaki Itoh
  • Journal Title: Journal of Alzheimer’s Disease & Parkinsonism Volume: 5 Issue: 5
  • DOI: 10.4172/2161-0460.1000270
  • Peer Reviewed / Open Access
• [Journal Article] Intracerebral Hemorrhage due to Venous Thrombosis of Developmental Venous Anomaly during Pregnancy. J (2015)
  • Author(s): Seki M, Shibata M, Itoh Y, Suzuki N
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 24 Issue: 7 Pages: 185-187
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.03.035
  • Peer Reviewed
• [Journal Article] Hyperperfusion counteracted by transient rapid vasoconstriction followed by long-lasting oligemia induced by cortical spreading depression in anesthetized mice. (2015)
  • Author(s): Unekawa M, Tomita Y, Toriumi H, Osada T, Masamoto K, Kawaguchi H, Itoh Y, Kanno I, Suzuki N.
  • Journal Title: J Cereb Blood Flow Metab Volume: 35 Issue: 4 Pages: 689-698
  • DOI: 10.1038/jcbfm.2014.250
  • Peer Reviewed / Open Access
• [Journal Article] Acute transient encephalomyelitis involving bilateral basal ganglia and internal capsules as manifestation of primary human immunodeficiency virus infection (2015)
  • Author(s): Tamura A, Shirano M, Shimono T, Takeda A, Tsutada T, Shimada H, Itoh Y.
  • Journal Title: Neurology and Clinical Neuroscience Volume: 3 Pages: 103-104
  • Peer Reviewed
• [Journal Article] 糖尿病による血管病変と認知症機能障害 (2015)
  • Author(s): 伊藤義彰
  • Journal Title: 脳循環代謝（日本脳循環代謝学会機関紙） Volume: 26(2) Pages: 129-134
  • Peer Reviewed
• [Presentation] 脳微小循環から見た脳血管攣縮の機序 (2017)
  • Author(s): 伊藤義彰
  • Organizer: 脳卒中学会2017
  • Place of Presentation: 大阪国際会議場(大阪府大阪市)
  • Year and Date: 2017-03-16
  • Invited
• [Presentation] Acceleration of red blood cells in intraparenchymal capillaries and dilation of arterial diameter in response to hypercapnia were diminished after passage of cortical spreading depression in anesthetized mice (2016)
  • Author(s): Yutaka Tomita, Miyuki Unekawa, Haruki Toriumi, Takashi Osada, Kazuto Masamoto, Hiroshi Kawaguchi, Yoshiaki Itoh, Iwao Kanno, Norihiro Suzuki
  • Organizer: 微小循環学会
  • Place of Presentation: コクヨホール(東京都港区)
  • Year and Date: 2016-09-24
• [Presentation] Rivaroxaban reduced the sizes of fibrin emboli in the intracranial arteries in mice even after embolic stroke occurred (2016)
  • Author(s): Masahiro Katsumata, Naoki Tsukada, Koichi Oki, Kazushi Minami, Kyoko Mashima, Takuya Iizumi, Takashi Osada, Takato Abe, Yoshiaki Itoh, Shinichi Takahashi, Norihiro Suzuki
  • Organizer: 微小循環学会
  • Place of Presentation: コクヨホール(東京都港区)
  • Year and Date: 2016-09-23
• [Presentation] Amyloid Accumulation in Patients with Dementia with Lewy Bodies and with Parkinson's Disease with Dementia (2016)
  • Author(s): Yoshiaki Itoh, Itsuki Hasegawa, Haruna Saito, Toshikazu Mino, Suzuka Ataka, Hiroyuki Shimada, Susumu Shiomi, Yasuhiro Wada, Yasuyoshi Watanabe
  • Organizer: CME 2016
  • Place of Presentation: 栃木県総合文化センター(栃木県宇都宮市)
  • Year and Date: 2016-08-05
  • Int'l Joint Research
• [Presentation] 脳アミロイドアンギオパチー患者におけるPIB集積の検討 (2016)
  • Author(s): 三野 俊和、長谷川 樹、江村 俊也、山川 義宏、竹内 潤、伊藤 和博、安宅 鈴香、 蔦田 強司、嶋田 裕之、安部 貴人、塩見進、和田康弘、渡辺恭良、伊藤 義彰
  • Organizer: 日本神経学会総会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2016-05-18
• [Presentation] MICROSPHERE EMBOLUS FROM THE COMMON CAROTID ARTERY CAN PRODUCE INFARCTION IN THE WATERSHED AREA IN MICE (2015)
  • Author(s): N Tsukada, M Katsumata, K Oki, T Abe, S Takahashi, Y Itoh, N Suzuki
  • Organizer: Brain 2015
  • Place of Presentation: カナダ(バンクーバー)
  • Year and Date: 2015-06-27
• [Presentation] Distribution in CBF Decrease in Clinically Diagnosed "Alzheimer Disease"Patients with vs.without Amyloid βAccumulation on PET (2015)
  • Author(s): Y Itoh
  • Organizer: CMC2015
  • Place of Presentation: 岡山コンベンションセンター(岡山県岡山市)
  • Year and Date: 2015-06-20
• [Presentation] Microsphere注入脳塞栓モデルにおける塞栓子径と分布の検討 (2015)
  • Author(s): 塚田直己1)、勝又雅裕1)、大木宏一1)、安部貴人1)、髙橋愼一1)、伊藤義彰2)、鈴木則宏1)
  • Organizer: 第40回日本脳卒中学会
  • Place of Presentation: リーガロイヤルホテル広島（広島県・広島市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] Microsphere注入脳塞栓モデルにおける塞栓子径と分布の検討 (2014)
  • Author(s): 塚田直己1)、勝又雅裕1)、大木宏一1)、安部貴人1)、髙橋愼一1)、伊藤義彰2)、鈴木則宏1)
  • Organizer: 第26回日本脳循環代謝学会
  • Place of Presentation: 岡山コンベンションセンター（岡山県・岡山市）
  • Year and Date: 2014-11-20 – 2014-11-22
• [Book] 脳血管障害（神経内科Clinical Questions & Pearls） (2016)
  • Author(s): 鈴木則宏、伊藤義彰、秋山久尚、上田雅之、山田 哲、山口啓二、田中亮太、安池政志、横田 元、山田 惠、此枝史恵、安部貴人、星野晴彦、秋山武紀、棚橋紀夫、山本康正、長尾毅太、堀口 崇、森原隆太、山下 徹、安部康二、大木宏一、山脇健盛、松本典子、木村和美、北川一夫、徳岡健太郎、野川 茂、黒田 敏、小泉健三、高嶋修太郎
  • Total Pages: 329
  • Publisher: 中外医学社
• [Remarks] 大阪市立大学大学院医学研究科神経内科
  • URL: http://www.med.osaka-cu.ac.jp/Neurology/index.html
• [Remarks] 大阪市立大学神経内科業績
  • URL: http://www.med.osaka-cu.ac.jp/Neurology/achievements.html