Phisiological significance of the liver-pancreatic beta-cell neuronal network

• Project/Area Number: 26461324
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Tohoku University
• Principal Investigator: Imai Junta 東北大学, 大学病院, 講師 (80431500)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 糖尿病 / 膵β細胞 / インスリン / 迷走神経

Outline of Final Research Achievements

We found that treatment of isolated islets with carbachol and several neuropeptides exponentially activated the Forkhead box protein M1 (FoxM1) pathway and enhanced β cell proliferation. Furthermore, we clarified that FoxM1 and its target genes are involved in β cell proliferation of mice in which liver-β cell neruronal network is activated and obese mice.

Research Products

• [Journal Article] Sodium-Glucose Cotransporter 2 Inhibitor Improves Complications of Lipodystrophy: A Case Report. (2017)
  • Author(s): Kawana Y, Imai J (corresponding author), Sawada S, Yamada T, Katagiri H
  • Journal Title: Ann Intern Med Volume: 166 Issue: 6 Pages: 450-451
  • DOI: 10.7326/l16-0372
  • Peer Reviewed
• [Journal Article] ES Stress Protein CHOP Mediates Insulin Resistanse by Modulating Adipose Tissue Macrophage Polarity. (2017)
  • Author(s): Suzuki T, Gao J, Ishigaki Y, Kondo K, Sawada S, Izumi T, Uno K, Kaneko K, Tsukita S, Takahashi K, Asao A, Ishii N, Imai J, Yamada T, Oyadomarai S, Katagiri H
  • Journal Title: Cell Rep Volume: 18 Issue: 8 Pages: 2045-2057
  • DOI: 10.1016/j.celrep.2017.01.076
  • Peer Reviewed / Open Access
• [Journal Article] Activation of Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholestrol Gallstones. (2017)
  • Author(s): Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, Ikeda M, Murakami K, Munakata Y, Shirai Y, Kodama S, Sugisawa T, Chiba Y, Kondo Y, Kaneko K, Uno K, Sawada S, Imai J, Nakamura Y, Yamaguchi H, Tanaka K, Sasano H, Mano N, Ueno Y, Shimosegawa T, Katagiri H
  • Journal Title: Gastroenterology Volume: 印刷中 Issue: 6 Pages: 30012-4
  • DOI: 10.1053/j.gastro.2017.01.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MicroRNAs 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes via Pancreatic beta-Cell Proliferation. (2016)
  • Author(s): Tsukita S, Yamada T, Takahashi K, Munakata Y, Hosaka S, Takahashi H, Gao J, Shirai Y, Kodama S, Asai Y, Sugisawa T, Chiba Y, Kaneko K, Uno K, Sawada S, Imai J, Katagiri H
  • Journal Title: EBioMedicine Volume: 15 Pages: 163-172
  • DOI: 10.1016/j.ebiom.2016.12.002
  • Peer Reviewed / Open Access
• [Journal Article] Dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, acutely reduces energy expenditure in BAT via neural signals in mice. (2016)
  • Author(s): Yumiko Chiba, Tetsuya Yamada, Sohei Tsukita, Kei Takahashi, Yuichiro Munakata, Yuta Shirai, Shinjiro Kodama, Yoichiro Asai, Takashi Sugisawa, Kenji Uno, Shojiro Sawada, Junta Imai, Kazuhiro Nakamura, Hideki Katagiri
  • Journal Title: PLOS ONE Volume: 11 Issue: 3 Pages: e0150756-e0150756
  • DOI: 10.1371/journal.pone.0150756
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] インスリン抵抗性下の膵β細胞増殖シグナル (2016)
  • Author(s): 今井淳太、片桐秀樹
  • Journal Title: 新時代の臨床糖尿病学 上 Volume: 74 Pages: 62-66
• [Journal Article] A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals (2015)
  • Author(s): Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Kaneko K, Ono H, Asano T, Oka Y, Katagiri H
  • Journal Title: Nat Commun Volume: 6 Issue: 1 Pages: 7940-7940
  • DOI: 10.1038/ncomms8940
  • Peer Reviewed / Open Access
• [Journal Article] Impacts of the Great East Japan Earthquake on diabetic patients. (2015)
  • Author(s): anaka M, Imai J, Satoh M, Hashimoto T, Izumi T, Sawada S, Uno K, Hasegawa Y, Kaneko K, Yamada T, Ishigaki Y, Imai Y and Katagiri H.
  • Journal Title: J Diabetes Invest. Volume: 印刷中 Issue: 5 Pages: 1-10
  • DOI: 10.1111/jdi.12336
  • Peer Reviewed / Open Access
• [Journal Article] 肝臓からの神経シグナル、液性因シグナルによる膵β細胞制御機構 (2015)
  • Author(s): 今井淳太、片桐秀樹
  • Journal Title: Islet Equality Volume: 4 Pages: 16-19
• [Journal Article] Glycemic control in diabetic patients with impaired endogenous insulin secretory capacity is vulnerable after a natural disaster: study of Great East Japan Earthquake (2014)
  • Author(s): Tanaka M, Imai J, Satoh M, Hashimoto T, Izumi T, Sawada S, Uno K, Hasegawa Y, Kaneko K, Yamada T, Ishigaki Y, Imai Y, Katagiri H
  • Journal Title: Diabetes Care Volume: 37(10) Issue: 10 Pages: e212-e213
  • DOI: 10.2337/dc14-1479
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Type B Insulin Resistance Syndrome as an H. Pylori-Associated Autoimmune Disease (Review) (2014)
  • Author(s): Imai J, Yamada T, Satoh J, Katagiri H
  • Journal Title: Journal of Endocrinology, Diabetes & Obesity Volume: 2 Pages: 1026-1032
  • Peer Reviewed
• [Journal Article] Simultaneous copy number losses within multiple subtelomeric regions in early-onset type 2 diabetes mellitus (2014)
  • Author(s): Kodama S, Yamada T, Imai J, Sawada S, Takahashi K, Tsukita S, Kaneko K, Uno K, Ishigaki Y, Oka Y, Katagiri H
  • Journal Title: PLoS One Volume: 9(4) Issue: 4 Pages: e88602-e88602
  • DOI: 10.1371/journal.pone.0088602
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 肝臓からのシグナルによる膵島制御機構 (2014)
  • Author(s): 今井淳太、片桐秀樹
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 39(2) Pages: 139-145
  • Peer Reviewed
• [Presentation] Regulation of pancreatic beta-cells by an inter-organ neuronal network of liver-pancreatic islets (2017)
  • Author(s): Junta Imai
  • Organizer: Asia Islet Bioloy&Incretin Symposium
  • Place of Presentation: ソウル,韓国
  • Year and Date: 2017-03-02
  • Int'l Joint Research / Invited
• [Presentation] Regulation of Pancreatic β cells by Parasympathetic Nerve Signals (2016)
  • Author(s): Junta Imai. Hideki Katagiri
  • Organizer: Japan Diabetes Innovation Summit
  • Place of Presentation: 京都（京都大学）
  • Year and Date: 2016-11-29
  • Int'l Joint Research / Invited
• [Presentation] Regulation of pancreatic beta-cells by vagal nerve signals (2016)
  • Author(s): Junta Imai, Hideki Katagiri
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 京都（国立京都国際会館）
  • Year and Date: 2016-05-19
  • Invited
• [Presentation] 迷走神経シグナルによる膵β細胞増殖機構 (2015)
  • Author(s): 今井淳太、片桐秀樹
  • Organizer: 第88回 日本内分泌学会総会
  • Place of Presentation: ホテルニューオータニ（東京都）
  • Year and Date: 2015-04-22
  • Invited
• [Presentation] 迷走神経シグナルによる膵β細胞制御機構 (2014)
  • Author(s): 今井淳太、片桐秀樹
  • Organizer: 第87回 日本生化学会
  • Place of Presentation: 国立京都国際会館 （京都市）
  • Year and Date: 2014-10-15 – 2014-10-18
  • Invited
• [Presentation] 神経シグナルと膵β細胞量の調節 (2014)
  • Author(s): 今井淳太、片桐秀樹
  • Organizer: 第87回 日本内分泌学会
  • Place of Presentation: 福岡国際会議場 （福岡市）
  • Year and Date: 2014-04-24 – 2014-04-26
  • Invited
• [Remarks] 東北大学大学院医学系研究科糖尿病代謝内科学分野
  • URL: http://www.diabetes.med.tohoku.ac.jp/