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Phisiological significance of the liver-pancreatic beta-cell neuronal network

Research Project

Project/Area Number 26461324
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionTohoku University

Principal Investigator

Imai Junta  東北大学, 大学病院, 講師 (80431500)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords糖尿病 / 膵β細胞 / インスリン / 迷走神経
Outline of Final Research Achievements

We found that treatment of isolated islets with carbachol and several neuropeptides exponentially activated the Forkhead box protein M1 (FoxM1) pathway and enhanced β cell proliferation. Furthermore, we clarified that FoxM1 and its target genes are involved in β cell proliferation of mice in which liver-β cell neruronal network is activated and obese mice.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (20 results)

All 2017 2016 2015 2014 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results) Remarks (1 results)

  • [Journal Article] Sodium-Glucose Cotransporter 2 Inhibitor Improves Complications of Lipodystrophy: A Case Report.2017

    • Author(s)
      Kawana Y, Imai J (corresponding author), Sawada S, Yamada T, Katagiri H
    • Journal Title

      Ann Intern Med

      Volume: 166 Issue: 6 Pages: 450-451

    • DOI

      10.7326/l16-0372

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity2017

    • Author(s)
      Suzuki T, Gao J, Ishigaki Y, Kondo K, Sawada S, Izumi T, Uno K, Kaneko K, Tsukita S, Takahashi K, Asao A, Ishii N, Imai J, Yamada T, Oyadomarai S, Katagiri H
    • Journal Title

      Cell Rep

      Volume: 18 Issue: 8 Pages: 2045

    • DOI

      10.1016/j.celrep.2017.01.076

    • NAID

      120007001421

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones2017

    • Author(s)
      Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, Ikeda M, Murakami K, Munakata Y, Shirai Y, Kodama S, Sugisawa T, Chiba Y, Kondo Y, Kaneko K, Uno K, Sawada S, Imai J, Nakamura Y, Yamaguchi H, Tanaka K, Sasano H, Mano N, Ueno Y, Shimosegawa T, Katagiri H
    • Journal Title

      Gastroenterology

      Volume: 152 Issue: 6 Pages: 1521

    • DOI

      10.1053/j.gastro.2017.01.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MicroRNAs 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes via Pancreatic β-Cell Proliferation2016

    • Author(s)
      Tsukita S, Yamada T, Takahashi K, Munakata Y, Hosaka S, Takahashi H, Gao J, Shirai Y, Kodama S, Asai Y, Sugisawa T, Chiba Y, Kaneko K, Uno K, Sawada S, Imai J, Katagiri H
    • Journal Title

      EBioMedicine

      Volume: 15 Pages: 163

    • DOI

      10.1016/j.ebiom.2016.12.002

    • NAID

      130007811669

    • URL

      https://pure.teikyo.jp/en/publications/297babbe-b305-4608-9a87-29fa0a000d06

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, acutely reduces energy expenditure in BAT via neural signals in mice2016

    • Author(s)
      Yumiko Chiba, Tetsuya Yamada, Sohei Tsukita, Kei Takahashi, Yuichiro Munakata, Yuta Shirai, Shinjiro Kodama, Yoichiro Asai, Takashi Sugisawa, Kenji Uno, Shojiro Sawada, Junta Imai, Kazuhiro Nakamura, Hideki Katagiri
    • Journal Title

      PLOS ONE

      Volume: 11 Issue: 3 Pages: e0150756-e0150756

    • DOI

      10.1371/journal.pone.0150756

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] インスリン抵抗性下の膵β細胞増殖シグナル2016

    • Author(s)
      今井淳太、片桐秀樹
    • Journal Title

      新時代の臨床糖尿病学 上

      Volume: 74 Pages: 62-66

    • Related Report
      2015 Research-status Report
  • [Journal Article] A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals2015

    • Author(s)
      Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Kaneko K, Ono H, Asano T, Oka Y, Katagiri H
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 7940-7940

    • DOI

      10.1038/ncomms8940

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impacts of the Great East Japan Earthquake on diabetic patients2015

    • Author(s)
      anaka M, Imai J, Satoh M, Hashimoto T, Izumi T, Sawada S, Uno K, Hasegawa Y, Kaneko K, Yamada T, Ishigaki Y, Imai Y and Katagiri H.
    • Journal Title

      J Diabetes Invest.

      Volume: 6 Issue: 5 Pages: 577

    • DOI

      10.1111/jdi.12336

    • URL

      https://pure.teikyo.jp/en/publications/a9a5e8e8-496e-4732-ad89-11ee1e0e9e33

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 肝臓からの神経シグナル、液性因シグナルによる膵β細胞制御機構2015

    • Author(s)
      今井淳太、片桐秀樹
    • Journal Title

      Islet Equality

      Volume: 4 Pages: 16-19

    • Related Report
      2015 Research-status Report
  • [Journal Article] Glycemic control in diabetic patients with impaired endogenous insulin secretory capacity is vulnerable after a natural disaster: Study of great east Japan earthquake2014

    • Author(s)
      Tanaka M, Imai J, Satoh M, Hashimoto T, Izumi T, Sawada S, Uno K, Hasegawa Y, Kaneko K, Yamada T, Ishigaki Y, Imai Y, Katagiri H
    • Journal Title

      Diabetes Care

      Volume: 37 Issue: 10 Pages: e212-e213

    • DOI

      10.2337/dc14-1479

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Type B Insulin Resistance Syndrome as an H. Pylori-Associated Autoimmune Disease (Review)2014

    • Author(s)
      Imai J, Yamada T, Satoh J, Katagiri H
    • Journal Title

      Journal of Endocrinology, Diabetes & Obesity

      Volume: 2 Pages: 1026-1032

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous copy number losses within multiple subtelomeric regions in early-onset type2 diabetes mellitus2014

    • Author(s)
      Kodama S, Yamada T, Imai J, Sawada S, Takahashi K, Tsukita S, Kaneko K, Uno K, Ishigaki Y, Oka Y, Katagiri H
    • Journal Title

      PLoS One

      Volume: 9 Issue: 4 Pages: e88602-e88602

    • DOI

      10.1371/journal.pone.0088602

    • URL

      https://pure.teikyo.jp/en/publications/23267795-82c2-44c4-9c73-2e7cd87bf18e

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 肝臓からのシグナルによる膵島制御機構2014

    • Author(s)
      今井淳太、片桐秀樹
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 39(2) Pages: 139-145

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Regulation of pancreatic beta-cells by an inter-organ neuronal network of liver-pancreatic islets2017

    • Author(s)
      Junta Imai
    • Organizer
      Asia Islet Bioloy&Incretin Symposium
    • Place of Presentation
      ソウル,韓国
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of Pancreatic β cells by Parasympathetic Nerve Signals2016

    • Author(s)
      Junta Imai. Hideki Katagiri
    • Organizer
      Japan Diabetes Innovation Summit
    • Place of Presentation
      京都(京都大学)
    • Year and Date
      2016-11-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of pancreatic beta-cells by vagal nerve signals2016

    • Author(s)
      Junta Imai, Hideki Katagiri
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 迷走神経シグナルによる膵β細胞増殖機構2015

    • Author(s)
      今井淳太、片桐秀樹
    • Organizer
      第88回 日本内分泌学会総会
    • Place of Presentation
      ホテルニューオータニ(東京都)
    • Year and Date
      2015-04-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 迷走神経シグナルによる膵β細胞制御機構2014

    • Author(s)
      今井淳太、片桐秀樹
    • Organizer
      第87回 日本生化学会
    • Place of Presentation
      国立京都国際会館 (京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 神経シグナルと膵β細胞量の調節2014

    • Author(s)
      今井淳太、片桐秀樹
    • Organizer
      第87回 日本内分泌学会
    • Place of Presentation
      福岡国際会議場 (福岡市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Remarks] 東北大学大学院医学系研究科糖尿病代謝内科学分野

    • URL

      http://www.diabetes.med.tohoku.ac.jp/

    • Related Report
      2016 Annual Research Report 2015 Research-status Report 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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