| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
This study was performed on the basis of the hypothesis that Semaphorin 3G (Sema3G) regulated glucagon secretion and contribute to the homeostasis of glucose metabolism.
Analysis of Sema3G deficient mice shows increase of pancreatic α cells and elevated expression of pancreas duodenum homeobox 1 (Pdx1) and Neurogenen3 (Ngn3), transcription factors essential for the differentiation and function maintenance of pancreatic endocrine cells. On the other hand, serum glucagon level was low and it was found that nerve cells were increased on the periphery of pancreatic islets and sympathetic nerve ending intruded into islets. These results indicates that Sema3G plays an important role in glucagon secretion by regulating proliferation and differentiation of pancreatic α cells and the organization of nerve network.
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