Role of TBP-2 in glucocorticoid-induced glucose intolerance

• Project/Area Number: 26461338
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kochi University
• Principal Investigator: FUJIMOTO Shimpei 高知大学, 教育研究部医療学系臨床医学部門, 教授 (00333576)
• Co-Investigator(Kenkyū-buntansha): 稲垣 暢也 京都大学, 医学研究科, 教授 (30241954)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: TBP-2 / グルココルチコイド / 耐糖能障害 / TBP2(TXNIP) / インスリン分泌障害 / インスリン抵抗性 / TBP-2 (TXNIP)

Outline of Final Research Achievements

In in vitro experiments using pancreatic beta cell line, glucocorticoid induced TBP-2-overexpression, however, role of TBP-2 in impairment of glucose-induced insulin secretion is not clear. In in vivo experiments, glucocorticoid-treatment brought about insulin resistance and reduced insulin signaling, but did not necessarily induce TBP-2-overexpression in skeletal muscle and liver. Therefore, role of TBP-2 in glucocorticoid-induced insulin resistance is not significant.