| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Impaired insulin secretion in response to glucose plays an important role in the pathogenesis of diabetes mellitus. Although endocytosis of secretory membranes after insulin release is essential for the tight control of insulin secretion, knowledge about this process in pancreatic beta-cells is still limited. Here, I searched for GDP-bound Rab27a interacting proteins and identified proton pumps. I found that GDP-bound Rab27a promotes the formation of the proton pump complex, which is required for its activity. These results suggest that GDP-bound Rab27a regulates endocytosis via acidification in endocytosed vesicles.
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