Regulation of bone metabolism by AKAP13

• Project/Area Number: 26461355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Chiba University
• Principal Investigator: KOIDE Hisashi 千葉大学, 医学部附属病院, 助教 (30507223)
• Co-Investigator(Kenkyū-buntansha): 田中 知明 千葉大学, 大学院医学研究院, 教授 (50447299) ; 吉田 知彦 千葉大学, 総合安全衛生管理機構, 助教 (20422222)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 骨代謝 / 骨粗鬆症 / 骨リモデリング / 骨形成 / メカニカルストレス / Rhoシグナル / 骨芽細胞

Outline of Final Research Achievements

AKAP13 is a protein that integrates various signaling such as mechanical stress and estrogen receptor activation. Analyses of animal and osteoblastic cells revealed that AKAP13 is involved in bone formation. AKAP13 plays an important role in the early stages of differentiation of osteoblasts, according to the expression analysis of the AKAP13 mRNA during differentiation of osteoblasts for bone formation, suggesting that AKAP13 may be an initiation trigger for osteogenic function and bone remodeling. We believe that analysis of AKAP13 and co-factor will lead to the development of new osteoporosis drugs the future.

Research Products

• [Journal Article] Mice Deficient in AKAP13 (BRX) Are Osteoporotic and Have Impaired Osteogenesis. (2015)
  • Author(s): Koide H, Holmbeck K, Lui JC, Guo XC, Driggers P, Chu T, Tatsuno I, Quaglieri C, Kino T, Baron J, Young MF, Robey PG, Segars JH.
  • Journal Title: Journal of Bone and Mineral Research Volume: - Issue: 10 Pages: 1887-1895
  • DOI: 10.1002/jbmr.2534
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 筋骨格系機能制御の解明と臨床応用の新機軸 AKAPにおける骨代謝制御 (2016)
  • Author(s): 小出尚史, 田中 知明, 横手 幸太郎
  • Organizer: 第34回日本骨代謝学会学術集会 あり方委員会シンポジウム 若手シンポジウム 内科系
  • Place of Presentation: 大阪国際会議場(大阪府大阪市)
  • Year and Date: 2016-07-20
  • Invited
• [Presentation] Mice Deficient in AKAP13 Are Osteoporotic and Have Impaired Osteogenesis (2016)
  • Author(s): Hisashi Koide, Kenn Holmbeck, Julian Lui, Paul H Driggerｓ, Akitoshi Nakayama, Tifferny Chu, Ichiro Tatsuno, Tomoaki Tanaka, Koutaro Yokote and James H. Segars
  • Organizer: Endocrine Society's 98th Annual Meeting and Expo
  • Place of Presentation: Boston Convention and Exhibition Center,Boston,USA
  • Year and Date: 2016-04-01
  • Int'l Joint Research