| Project/Area Number |
26461356
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Nagasaki Mika 東京大学, 医学部附属病院, 特任研究員 (70456135)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NISHIMURA Satoshi 自治医科大学, 分子病態治療研究センター, 教授 (80456136)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | メタボリックシンドローム / 生体分子イメージング / 脂肪組織 / 炎症 / 生体イメージング / 慢性炎症 |
|---|
| Outline of Final Research Achievements |
Using in vivo imaging technique, we show that nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2, autotaxin) is an adipose-derived, secreted enzyme that controls adipose expansion, brown adipose tissue function, and energy expenditure. Our result also suggest ENPP2 could be a useful therapeutic target for the treatment of metabolic disease (2014 Diabetes). We identified GM3(d18:1-h24:1) as the best candidate for metabolic screening, proving to be significantly correlated with intima-media thickness, used for the detection of atherosclerotic disease in humans, and a number of metabolic disease risk factors including autotaxin, LDL-c and homeostatic model assessment insulin resistance (HOMA-IR) (2015 PLos One). Moreover, we presented serum adiponectin measurements in Periodic Health Checks can predict the incidence of arteriosclerosis progressions, and FL, independent of obesity.
|
