Elucidation of immune cell activation mechanism in metabolic diseases using in vivo imaging
Project/Area Number |
26461356
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | The University of Tokyo |
Principal Investigator |
Nagasaki Mika 東京大学, 医学部附属病院, 特任研究員 (70456135)
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Co-Investigator(Renkei-kenkyūsha) |
NISHIMURA Satoshi 自治医科大学, 分子病態治療研究センター, 教授 (80456136)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | メタボリックシンドローム / 生体分子イメージング / 脂肪組織 / 炎症 / 生体イメージング / 慢性炎症 |
Outline of Final Research Achievements |
Using in vivo imaging technique, we show that nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2, autotaxin) is an adipose-derived, secreted enzyme that controls adipose expansion, brown adipose tissue function, and energy expenditure. Our result also suggest ENPP2 could be a useful therapeutic target for the treatment of metabolic disease (2014 Diabetes). We identified GM3(d18:1-h24:1) as the best candidate for metabolic screening, proving to be significantly correlated with intima-media thickness, used for the detection of atherosclerotic disease in humans, and a number of metabolic disease risk factors including autotaxin, LDL-c and homeostatic model assessment insulin resistance (HOMA-IR) (2015 PLos One). Moreover, we presented serum adiponectin measurements in Periodic Health Checks can predict the incidence of arteriosclerosis progressions, and FL, independent of obesity.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] IL-1 alpha induces rapid enhanced platelet biogenesis through rupture of Running title: Rupture thrombopoiesis regulated by IL-1alpha murine bone marrow megakaryocytes2015
Author(s)
Satoshi Nishimura, Mika Nagasaki, Shinji Kunishima, Asuka Sakata, Hiroyasu Sakaguchi, Naoya Takayama, Issei Komuro, Joe Italiano Jr., Tomiko Ryu, Tsukasa Ohmori, Takashi Kadowaki, Koji Eto, Ryozo Nagai
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Journal Title
Journal of cell biology
Volume: 未
Issue: 3
Pages: 453-66
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] ENPP2 contributes to adipose tissue expansion and insulin resistance in diet-induced obesity.2014
Author(s)
Nishimura S, Nagasaki M, Okudaira S, Aoki J, Ohmori T, Ohkawa R, Nakamura K, Igarashi K, Yamashita H, Eto K, Uno K, Hayashi N, Kadowaki T, Komuro I, Yatomi Y, Nagai R.
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Journal Title
Diabetes
Volume: 63
Issue: 12
Pages: 4154-4164
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] スフィンゴミエリン、ホスファチジルコリンおよびリゾホスファジルコリンの血中動態の検討2014
Author(s)
大川 龍之介, 蔵野 信, 岸本 達也, 松山 直人, 長崎 実佳, 宇野 漢成, 林 直人, 大久保 滋夫, 池田 均, 戸塚 実, 矢冨 裕
Organizer
第54回臨床科学学会
Place of Presentation
東京
Year and Date
2014-09-05 – 2014-09-07
Related Report
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