Roles of Sdf2l1, a novel modulator of endoplasmic reticulum stress, on pathogenesis of obesity-induced diabetes and non-alcoholic steatohepatitis in mice and humans
| Project/Area Number |
26461358
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | インスリン抵抗性 / 小胞体ストレス / 糖尿病 / 脂肪性肝炎 / 肝生検 |
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| Outline of Final Research Achievements |
It was revealed that, in mice and cultured cells, Sdf2l1, a molecule that we have focused on as the key modulator of feeding-induced endoplasmic reticulum (ER) stress in the liver, binds to TMED10, a trafficking protein located on the ER membrane, and are involved in the maintenance of ER functions in a cooperative manner. It was also shown that, in liver biopsy samples of human subjects with diabetes, ER stress response 'failure', as well as ER stress itself, was involved in the development of steatohepatitis associated with insulin resistance.
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Report
(4 results)
Research Products
(23 results)
