| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
It was revealed that, in mice and cultured cells, Sdf2l1, a molecule that we have focused on as the key modulator of feeding-induced endoplasmic reticulum (ER) stress in the liver, binds to TMED10, a trafficking protein located on the ER membrane, and are involved in the maintenance of ER functions in a cooperative manner. It was also shown that, in liver biopsy samples of human subjects with diabetes, ER stress response 'failure', as well as ER stress itself, was involved in the development of steatohepatitis associated with insulin resistance.
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